eF-site ID 6d2p-CHL
PDB Code 6d2p
Chain C, H, L

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Title Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A
Classification IMMUNE SYSTEM
Compound Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8
Source (6D2P)
Sequence C:  DTITLPCRPAPPPHCSSNITGLILTRQGGYSNANTVIFRP
SGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDW
RDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIA
SKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCAS
TQLFASTWF
H:  QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQA
PGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAY
MELSRLRSDDTAVYYCARSLGRDWFDPWGQGTLVTVSSAS
TKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSG
VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP
SNTKVDKKVEPKS
L:  SALTQPASVSGSPGQSITISCTGTSSDVGSNLVSWYQQHP
GKAPKLMIYEGSKRPSGVSNRFSGSKSGNTASLTISGLQA
EDEADYYCCSYAGSVVFGGGTKLTVLGQPKAAPSVTLFPP
SSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVE
TTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGS
TVEKTVAPTE
Description


Functional site

1) chain C
residue 14
type
sequence H
description binding site for residue GOL C 201
source : AC1

2) chain C
residue 16
type
sequence S
description binding site for residue GOL C 201
source : AC1

3) chain C
residue 17
type
sequence S
description binding site for residue GOL C 201
source : AC1

4) chain C
residue 65
type
sequence N
description binding site for residue GOL C 201
source : AC1

5) chain C
residue 18
type
sequence N
description binding site for residue GOL C 202
source : AC2

6) chain C
residue 96
type
sequence E
description binding site for residue GOL C 202
source : AC2

7) chain C
residue 137
type
sequence S
description binding site for residue GOL C 203
source : AC3

8) chain C
residue 145
type
sequence V
description binding site for residue GOL C 203
source : AC3

9) chain C
residue 146
type
sequence N
description binding site for residue GOL C 203
source : AC3

10) chain C
residue 159
type
sequence A
description binding site for residue GOL C 203
source : AC3

11) chain C
residue 160
type
sequence S
description binding site for residue GOL C 203
source : AC3

12) chain C
residue 161
type
sequence T
description binding site for residue GOL C 203
source : AC3

13) chain H
residue 10
type
sequence E
description binding site for residue GOL H 301
source : AC4

14) chain H
residue 19
type
sequence K
description binding site for residue GOL H 301
source : AC4

15) chain C
residue 82
type
sequence D
description binding site for residue GOL H 302
source : AC5

16) chain C
residue 84
type
sequence A
description binding site for residue GOL H 302
source : AC5

17) chain C
residue 85
type
sequence K
description binding site for residue GOL H 302
source : AC5

18) chain H
residue 33
type
sequence Y
description binding site for residue GOL H 302
source : AC5

19) chain H
residue 99
type
sequence S
description binding site for residue GOL H 302
source : AC5

20) chain H
residue 101
type
sequence G
description binding site for residue GOL H 302
source : AC5

21) chain H
residue 199-205
type prosite
sequence YICNVNH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
source prosite : PS00290

22) chain L
residue 194-200
type prosite
sequence YSCQVTH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
source prosite : PS00290


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