eF-site ID 6d2i-B
PDB Code 6d2i
Chain B

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Title JAK2 Pseudokinase V617F in complex with AT9283
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Tyrosine-protein kinase
Source (Q506Q0_HUMAN)
Sequence B:  FHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHET
EVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVC
FCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQ
LAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIK
LSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDK
WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK
AAELANLINNCMDYEPDHRPSFRAIIRDLNSL
Description


Functional site

1) chain B
residue 559
type
sequence I
description binding site for residue 35R B 901
source : AC2

2) chain B
residue 579
type
sequence L
description binding site for residue 35R B 901
source : AC2

3) chain B
residue 581
type
sequence K
description binding site for residue 35R B 901
source : AC2

4) chain B
residue 627
type
sequence E
description binding site for residue 35R B 901
source : AC2

5) chain B
residue 629
type
sequence V
description binding site for residue 35R B 901
source : AC2

6) chain B
residue 630
type
sequence K
description binding site for residue 35R B 901
source : AC2

7) chain B
residue 631
type
sequence F
description binding site for residue 35R B 901
source : AC2

8) chain B
residue 632
type
sequence G
description binding site for residue 35R B 901
source : AC2

9) chain B
residue 633
type
sequence S
description binding site for residue 35R B 901
source : AC2

10) chain B
residue 677
type
sequence K
description binding site for residue 35R B 901
source : AC2

11) chain B
residue 680
type
sequence L
description binding site for residue 35R B 901
source : AC2

12) chain B
residue 698
type
sequence S
description binding site for residue 35R B 901
source : AC2

13) chain B
residue 710
type SITE
sequence D
description Breakpoint for translocation to form PCM1-JAK2 fusion protein
source Swiss-Prot : SWS_FT_FI1

14) chain B
residue 570
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI2


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