eF-site ID 6d2i-AB PDB Code 6d2i Chain A, B click to enlarge Title JAK2 Pseudokinase V617F in complex with AT9283 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tyrosine-protein kinase Source (Q506Q0_HUMAN) Sequence A:  VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHE TEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGV CFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFI KLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATD KWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAP KAAELANLINNCMDYEPDHRPSFRAIIRDLNSL B:  FHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHET EVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVC FCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQ LAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIK LSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDK WSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK AAELANLINNCMDYEPDHRPSFRAIIRDLNSL Description Functional site 1) chain A residue 551 type sequence L description binding site for residue 35R A 901 source : AC1 2) chain A residue 559 type sequence I description binding site for residue 35R A 901 source : AC1 3) chain A residue 579 type sequence L description binding site for residue 35R A 901 source : AC1 4) chain A residue 581 type sequence K description binding site for residue 35R A 901 source : AC1 5) chain A residue 627 type sequence E description binding site for residue 35R A 901 source : AC1 6) chain A residue 628 type sequence F description binding site for residue 35R A 901 source : AC1 7) chain A residue 629 type sequence V description binding site for residue 35R A 901 source : AC1 8) chain A residue 630 type sequence K description binding site for residue 35R A 901 source : AC1 9) chain A residue 631 type sequence F description binding site for residue 35R A 901 source : AC1 10) chain A residue 633 type sequence S description binding site for residue 35R A 901 source : AC1 11) chain A residue 680 type sequence L description binding site for residue 35R A 901 source : AC1 12) chain A residue 698 type sequence S description binding site for residue 35R A 901 source : AC1 13) chain B residue 559 type sequence I description binding site for residue 35R B 901 source : AC2 14) chain B residue 579 type sequence L description binding site for residue 35R B 901 source : AC2 15) chain B residue 581 type sequence K description binding site for residue 35R B 901 source : AC2 16) chain B residue 627 type sequence E description binding site for residue 35R B 901 source : AC2 17) chain B residue 629 type sequence V description binding site for residue 35R B 901 source : AC2 18) chain B residue 630 type sequence K description binding site for residue 35R B 901 source : AC2 19) chain B residue 631 type sequence F description binding site for residue 35R B 901 source : AC2 20) chain B residue 632 type sequence G description binding site for residue 35R B 901 source : AC2 21) chain B residue 633 type sequence S description binding site for residue 35R B 901 source : AC2 22) chain B residue 677 type sequence K description binding site for residue 35R B 901 source : AC2 23) chain B residue 680 type sequence L description binding site for residue 35R B 901 source : AC2 24) chain B residue 698 type sequence S description binding site for residue 35R B 901 source : AC2 25) chain A residue 710 type SITE sequence D description Breakpoint for translocation to form PCM1-JAK2 fusion protein source Swiss-Prot : SWS_FT_FI1 26) chain B residue 710 type SITE sequence D description Breakpoint for translocation to form PCM1-JAK2 fusion protein source Swiss-Prot : SWS_FT_FI1 27) chain A residue 570 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 570 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2

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