eF-site ID 6d2i-A
PDB Code 6d2i
Chain A

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Title JAK2 Pseudokinase V617F in complex with AT9283
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Tyrosine-protein kinase
Source (Q506Q0_HUMAN)
Sequence A:  VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHE
TEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGV
CFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK
QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFI
KLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATD
KWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAP
KAAELANLINNCMDYEPDHRPSFRAIIRDLNSL
Description


Functional site

1) chain A
residue 551
type
sequence L
description binding site for residue 35R A 901
source : AC1

2) chain A
residue 559
type
sequence I
description binding site for residue 35R A 901
source : AC1

3) chain A
residue 579
type
sequence L
description binding site for residue 35R A 901
source : AC1

4) chain A
residue 581
type
sequence K
description binding site for residue 35R A 901
source : AC1

5) chain A
residue 627
type
sequence E
description binding site for residue 35R A 901
source : AC1

6) chain A
residue 628
type
sequence F
description binding site for residue 35R A 901
source : AC1

7) chain A
residue 629
type
sequence V
description binding site for residue 35R A 901
source : AC1

8) chain A
residue 630
type
sequence K
description binding site for residue 35R A 901
source : AC1

9) chain A
residue 631
type
sequence F
description binding site for residue 35R A 901
source : AC1

10) chain A
residue 633
type
sequence S
description binding site for residue 35R A 901
source : AC1

11) chain A
residue 680
type
sequence L
description binding site for residue 35R A 901
source : AC1

12) chain A
residue 698
type
sequence S
description binding site for residue 35R A 901
source : AC1

13) chain A
residue 710
type SITE
sequence D
description Breakpoint for translocation to form PCM1-JAK2 fusion protein
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 570
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI2


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