eF-site ID 6d19-A PDB Code 6d19 Chain A click to enlarge Title Crystal structure of KPC-2 complexed with compound 9 Classification HYDROLASE/HYDROLASE inhibitor Compound Carbapenem-hydrolyzing beta-lactamase KPC Source (BLKPC_KLEPN) Sequence A:  MLTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEE RFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVP WSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGG PAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPR AVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAA VPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYT RAPNKDDKHSEAVIAAAARLALEGLGVNG Description Functional site 1) chain A residue 70 type sequence S description binding site for residue YKG A 301 source : AC1 2) chain A residue 105 type sequence W description binding site for residue YKG A 301 source : AC1 3) chain A residue 130 type sequence S description binding site for residue YKG A 301 source : AC1 4) chain A residue 234 type sequence K description binding site for residue YKG A 301 source : AC1 5) chain A residue 235 type sequence T description binding site for residue YKG A 301 source : AC1 6) chain A residue 236 type sequence G description binding site for residue YKG A 301 source : AC1 7) chain A residue 237 type sequence T description binding site for residue YKG A 301 source : AC1 8) chain A residue 136 type sequence N description binding site for residue YKG A 302 source : AC2 9) chain A residue 165 type sequence W description binding site for residue YKG A 302 source : AC2 10) chain A residue 166 type sequence E description binding site for residue YKG A 302 source : AC2 11) chain A residue 83 type sequence R description binding site for residue YKG A 303 source : AC3 12) chain A residue 147 type sequence G description binding site for residue YKG A 303 source : AC3 13) chain A residue 150 type sequence A description binding site for residue YKG A 303 source : AC3 14) chain A residue 151 type sequence F description binding site for residue YKG A 303 source : AC3 15) chain A residue 154 type sequence S description binding site for residue YKG A 303 source : AC3 16) chain A residue 205 type sequence Q description binding site for residue GOL A 304 source : AC4 17) chain A residue 212 type sequence K description binding site for residue GOL A 304 source : AC4 18) chain A residue 230 type sequence A description binding site for residue GOL A 304 source : AC4 19) chain A residue 70 type ACT_SITE sequence S description Acyl-ester intermediate => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 168 type ACT_SITE sequence E description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 234 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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