eF-site ID 6czu-A
PDB Code 6czu
Chain A

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Title BRD4(BD1) complexed with 3219
Classification TRANSCRIPTION/INHIBITOR
Compound Bromodomain-containing protein 4
Source (BRD4_HUMAN)
Sequence A:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW
PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN
AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEETE
Description (1)  Bromodomain-containing protein 4


Functional site

1) chain A
residue 51
type
sequence S
description binding site for residue FP7 A 201
source : AC1

2) chain A
residue 82
type
sequence P
description binding site for residue FP7 A 201
source : AC1

3) chain A
residue 92
type
sequence L
description binding site for residue FP7 A 201
source : AC1

4) chain A
residue 116
type
sequence N
description binding site for residue FP7 A 201
source : AC1

5) chain A
residue 140
type
sequence N
description binding site for residue FP7 A 201
source : AC1

6) chain A
residue 145
type
sequence D
description binding site for residue FP7 A 201
source : AC1

7) chain A
residue 149
type
sequence M
description binding site for residue FP7 A 201
source : AC1

8) chain A
residue 42
type
sequence S
description binding site for residue EDO A 202
source : AC2

9) chain A
residue 54
type
sequence N
description binding site for residue EDO A 202
source : AC2

10) chain A
residue 51
type
sequence S
description binding site for residue EDO A 203
source : AC3

11) chain A
residue 52
type
sequence N
description binding site for residue EDO A 203
source : AC3

12) chain A
residue 55
type
sequence K
description binding site for residue EDO A 203
source : AC3

13) chain A
residue 57
type
sequence K
description binding site for residue EDO A 203
source : AC3

14) chain A
residue 81
type
sequence W
description binding site for residue EDO A 203
source : AC3

15) chain A
residue 116
type
sequence N
description binding site for residue EDO A 203
source : AC3

16) chain A
residue 118
type
sequence Y
description binding site for residue EDO A 203
source : AC3

17) chain A
residue 100
type
sequence I
description binding site for residue EDO A 204
source : AC4

18) chain A
residue 101
type
sequence I
description binding site for residue EDO A 204
source : AC4

19) chain A
residue 102
type
sequence K
description binding site for residue EDO A 204
source : AC4

20) chain A
residue 103
type
sequence T
description binding site for residue EDO A 204
source : AC4

21) chain A
residue 135
type
sequence N
description binding site for residue EDO A 204
source : AC4

22) chain A
residue 160
type
sequence K
description binding site for residue EDO A 204
source : AC4

23) chain A
residue 170
type
sequence E
description binding site for residue EDO A 204
source : AC4

24) chain A
residue 91
type
sequence K
description binding site for residue DMS A 205
source : AC5

25) chain A
residue 99
type
sequence K
description binding site for residue DMS A 205
source : AC5

26) chain A
residue 102
type
sequence K
description binding site for residue DMS A 205
source : AC5

27) chain A
residue 43
type
sequence M
description binding site for residue EDO A 206
source : AC6

28) chain A
residue 52
type
sequence N
description binding site for residue EDO A 206
source : AC6

29) chain A
residue 62
type
sequence Q
description binding site for residue EDO A 206
source : AC6

30) chain A
residue 123
type
sequence Q
description binding site for residue EDO A 206
source : AC6

31) chain A
residue 126
type
sequence I
description binding site for residue EDO A 206
source : AC6

32) chain A
residue 73
type
sequence T
description binding site for residue EDO A 207
source : AC7

33) chain A
residue 76
type
sequence K
description binding site for residue EDO A 207
source : AC7

34) chain A
residue 77
type
sequence H
description binding site for residue EDO A 207
source : AC7

35) chain A
residue 130
type
sequence N
description binding site for residue EDO A 207
source : AC7

36) chain A
residue 131
type
sequence T
description binding site for residue EDO A 207
source : AC7

37) chain A
residue 134
type
sequence T
description binding site for residue EDO A 207
source : AC7

38) chain A
residue 57
type
sequence K
description binding site for residue EDO A 208
source : AC8

39) chain A
residue 59
type
sequence Q
description binding site for residue EDO A 208
source : AC8

40) chain A
residue 91
type
sequence K
description binding site for residue EDO A 208
source : AC8

41) chain A
residue 53
type
sequence P
description binding site for residue EDO A 209
source : AC9

42) chain A
residue 55
type
sequence K
description binding site for residue EDO A 209
source : AC9

43) chain A
residue 99
type
sequence K
description binding site for residue EDO A 209
source : AC9

44) chain A
residue 80-139
type prosite
sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
WNAQECIQDFNTMFTNCYIY
description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
source prosite : PS00633

45) chain A
residue 140
type SITE
sequence N
description Acetylated histone binding => ECO:0000269|PubMed:22464331
source Swiss-Prot : SWS_FT_FI1

46) chain A
residue 99
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI2


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