eF-site ID 6czu-A PDB Code 6czu Chain A click to enlarge Title BRD4(BD1) complexed with 3219 Classification TRANSCRIPTION/INHIBITOR Compound Bromodomain-containing protein 4 Source (BRD4_HUMAN) Sequence A:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEETE Description (1)  Bromodomain-containing protein 4 Functional site 1) chain A residue 51 type sequence S description binding site for residue FP7 A 201 source : AC1 2) chain A residue 82 type sequence P description binding site for residue FP7 A 201 source : AC1 3) chain A residue 92 type sequence L description binding site for residue FP7 A 201 source : AC1 4) chain A residue 116 type sequence N description binding site for residue FP7 A 201 source : AC1 5) chain A residue 140 type sequence N description binding site for residue FP7 A 201 source : AC1 6) chain A residue 145 type sequence D description binding site for residue FP7 A 201 source : AC1 7) chain A residue 149 type sequence M description binding site for residue FP7 A 201 source : AC1 8) chain A residue 42 type sequence S description binding site for residue EDO A 202 source : AC2 9) chain A residue 54 type sequence N description binding site for residue EDO A 202 source : AC2 10) chain A residue 51 type sequence S description binding site for residue EDO A 203 source : AC3 11) chain A residue 52 type sequence N description binding site for residue EDO A 203 source : AC3 12) chain A residue 55 type sequence K description binding site for residue EDO A 203 source : AC3 13) chain A residue 57 type sequence K description binding site for residue EDO A 203 source : AC3 14) chain A residue 81 type sequence W description binding site for residue EDO A 203 source : AC3 15) chain A residue 116 type sequence N description binding site for residue EDO A 203 source : AC3 16) chain A residue 118 type sequence Y description binding site for residue EDO A 203 source : AC3 17) chain A residue 100 type sequence I description binding site for residue EDO A 204 source : AC4 18) chain A residue 101 type sequence I description binding site for residue EDO A 204 source : AC4 19) chain A residue 102 type sequence K description binding site for residue EDO A 204 source : AC4 20) chain A residue 103 type sequence T description binding site for residue EDO A 204 source : AC4 21) chain A residue 135 type sequence N description binding site for residue EDO A 204 source : AC4 22) chain A residue 160 type sequence K description binding site for residue EDO A 204 source : AC4 23) chain A residue 170 type sequence E description binding site for residue EDO A 204 source : AC4 24) chain A residue 91 type sequence K description binding site for residue DMS A 205 source : AC5 25) chain A residue 99 type sequence K description binding site for residue DMS A 205 source : AC5 26) chain A residue 102 type sequence K description binding site for residue DMS A 205 source : AC5 27) chain A residue 43 type sequence M description binding site for residue EDO A 206 source : AC6 28) chain A residue 52 type sequence N description binding site for residue EDO A 206 source : AC6 29) chain A residue 62 type sequence Q description binding site for residue EDO A 206 source : AC6 30) chain A residue 123 type sequence Q description binding site for residue EDO A 206 source : AC6 31) chain A residue 126 type sequence I description binding site for residue EDO A 206 source : AC6 32) chain A residue 73 type sequence T description binding site for residue EDO A 207 source : AC7 33) chain A residue 76 type sequence K description binding site for residue EDO A 207 source : AC7 34) chain A residue 77 type sequence H description binding site for residue EDO A 207 source : AC7 35) chain A residue 130 type sequence N description binding site for residue EDO A 207 source : AC7 36) chain A residue 131 type sequence T description binding site for residue EDO A 207 source : AC7 37) chain A residue 134 type sequence T description binding site for residue EDO A 207 source : AC7 38) chain A residue 57 type sequence K description binding site for residue EDO A 208 source : AC8 39) chain A residue 59 type sequence Q description binding site for residue EDO A 208 source : AC8 40) chain A residue 91 type sequence K description binding site for residue EDO A 208 source : AC8 41) chain A residue 53 type sequence P description binding site for residue EDO A 209 source : AC9 42) chain A residue 55 type sequence K description binding site for residue EDO A 209 source : AC9 43) chain A residue 99 type sequence K description binding site for residue EDO A 209 source : AC9 44) chain A residue 80-139 type prosite sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY WNAQECIQDFNTMFTNCYIY description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY source prosite : PS00633 45) chain A residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2

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