eF-site ID 6czn-A PDB Code 6czn Chain A click to enlarge Title Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Z2OHTPE and a glucocorticoid receptor-interacting protein 1 NR box II peptide Classification NUCLEAR PROTEIN Compound Estrogen receptor Source (6CZN) Sequence A:  LSLTADQMVSALLDAEPPILYSSEASMMGLLTNLADRELV HMINWAKRVPGFVDLTDQVHLLECAWLEILMIGLVWRSME HPGKLLFAPNLLLDRNKEGMVEIFDMLLATSSRFRMMNLQ GEEFVCLKSIILLNSGVYTFSLEEKDHIHRVLDKITDTLI HLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYL SDLLLEMLDAHR Description Functional site 1) chain A residue 350 type sequence A description binding site for residue FNJ A 601 source : AC1 2) chain A residue 353 type sequence E description binding site for residue FNJ A 601 source : AC1 3) chain A residue 383 type sequence W description binding site for residue FNJ A 601 source : AC1 4) chain A residue 387 type sequence L description binding site for residue FNJ A 601 source : AC1 5) chain A residue 394 type sequence R description binding site for residue FNJ A 601 source : AC1 6) chain A residue 404 type sequence F description binding site for residue FNJ A 601 source : AC1 7) chain A residue 421 type sequence M description binding site for residue FNJ A 601 source : AC1 8) chain A residue 428 type sequence L description binding site for residue FNJ A 601 source : AC1 9) chain A residue 521 type sequence G description binding site for residue FNJ A 601 source : AC1 10) chain A residue 524 type sequence H description binding site for residue FNJ A 601 source : AC1 11) chain A residue 525 type sequence L description binding site for residue FNJ A 601 source : AC1 12) chain A residue 340 type MOD_RES sequence A description Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 433 type MOD_RES sequence S description Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420 source Swiss-Prot : SWS_FT_FI4 14) chain A residue 358-423 type DNA_BIND sequence INWAKRVPGFVDLTDQVHLLECAWLEILMIGLVWRSMEHP GKLLFAPNLLLDRNKEGMVE description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 358-378 type ZN_FING sequence INWAKRVPGFVDLTDQVHL description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2

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