eF-site ID 6cz3-A PDB Code 6cz3 Chain A click to enlarge Title Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone Classification Transferase/Transferase Inhibitor Compound Protein-tyrosine kinase 6 Source (PTK6_HUMAN) Sequence A:  DDAERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVI SRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVY IITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC YLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDV YLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMF SRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLML TCWCRDPEQRPCFKALRERLSS Description Functional site 1) chain A residue 195 type sequence R description binding site for residue FLJ A 9001 source : AC1 2) chain A residue 197 type sequence L description binding site for residue FLJ A 9001 source : AC1 3) chain A residue 205 type sequence V description binding site for residue FLJ A 9001 source : AC1 4) chain A residue 217 type sequence A description binding site for residue FLJ A 9001 source : AC1 5) chain A residue 219 type sequence K description binding site for residue FLJ A 9001 source : AC1 6) chain A residue 248 type sequence L description binding site for residue FLJ A 9001 source : AC1 7) chain A residue 264 type sequence T description binding site for residue FLJ A 9001 source : AC1 8) chain A residue 265 type sequence E description binding site for residue FLJ A 9001 source : AC1 9) chain A residue 266 type sequence L description binding site for residue FLJ A 9001 source : AC1 10) chain A residue 267 type sequence M description binding site for residue FLJ A 9001 source : AC1 11) chain A residue 268 type sequence A description binding site for residue FLJ A 9001 source : AC1 12) chain A residue 270 type sequence G description binding site for residue FLJ A 9001 source : AC1 13) chain A residue 282 type sequence K description binding site for residue FLJ A 9001 source : AC1 14) chain A residue 330 type sequence D description binding site for residue FLJ A 9001 source : AC1 15) chain A residue 223 type sequence R description binding site for residue ACT A 9002 source : AC2 16) chain A residue 229 type sequence Q description binding site for residue ACT A 9002 source : AC2 17) chain A residue 186 type sequence R description binding site for residue ACT A 9003 source : AC3 18) chain A residue 210 type sequence W description binding site for residue ACT A 9003 source : AC3 19) chain A residue 211 type sequence K description binding site for residue ACT A 9003 source : AC3 20) chain A residue 213 type sequence R description binding site for residue ACT A 9003 source : AC3 21) chain A residue 338 type sequence K description binding site for residue ACT A 9003 source : AC3 22) chain A residue 339 type sequence E description binding site for residue ACT A 9003 source : AC3 23) chain A residue 231 type sequence M description binding site for residue ACT A 9004 source : AC4 24) chain A residue 327 type sequence K description binding site for residue ACT A 9004 source : AC4 25) chain A residue 399 type sequence R description binding site for residue ACT A 9005 source : AC5 26) chain A residue 402 type sequence A description binding site for residue ACT A 9005 source : AC5 27) chain A residue 404 type sequence Y description binding site for residue ACT A 9005 source : AC5 28) chain A residue 360 type sequence S description binding site for residue ACT A 9006 source : AC6 29) chain A residue 361 type sequence R description binding site for residue ACT A 9006 source : AC6 30) chain A residue 401 type sequence D description binding site for residue ACT A 9006 source : AC6 31) chain A residue 304 type sequence E description binding site for residue ACT A 9007 source : AC7 32) chain A residue 307 type sequence N description binding site for residue ACT A 9007 source : AC7 33) chain A residue 212 type sequence D description binding site for residue ACT A 9008 source : AC8 34) chain A residue 351 type sequence Y description binding site for residue ACT A 9008 source : AC8 35) chain A residue 394 type sequence H description binding site for residue ACT A 9008 source : AC8 36) chain A residue 189 type sequence E description binding site for residue K A 9009 source : AC9 37) chain A residue 191 type sequence F description binding site for residue K A 9009 source : AC9 38) chain A residue 192 type sequence T description binding site for residue K A 9009 source : AC9 39) chain A residue 223 type sequence R description binding site for residue K A 9010 source : AD1 40) chain A residue 226 type sequence L description binding site for residue K A 9010 source : AD1 41) chain A residue 197 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 219 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:27480927, ECO:0000305|PubMed:27993680 source Swiss-Prot : SWS_FT_FI3 43) chain A residue 312 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 342 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12121988 source Swiss-Prot : SWS_FT_FI4 45) chain A residue 351 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12121988 source Swiss-Prot : SWS_FT_FI4 46) chain A residue 197-219 type prosite sequence LGSGYFGEVFEGLWKDRVQVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGYFGEVFeGlwkdrvq...........VAIK source prosite : PS00107 47) chain A residue 308-320 type prosite sequence YIHRDLAARNILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLAARNILV source prosite : PS00109

Display surface Download Links