eF-site ID 6cxk-A PDB Code 6cxk Chain A click to enlarge Title E. coli DHFR substrate complex with Dihydrofolate Classification OXIDOREDUCTASE Compound Dihydrofolate reductase Source (DYR_ECOL6) Sequence A:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERRH HHHHH Description Functional site 1) chain A residue 101 type sequence E description binding site for residue MG A 201 source : AC1 2) chain A residue 139 type sequence E description binding site for residue MG A 201 source : AC1 3) chain A residue 101 type sequence E description binding site for residue MG A 202 source : AC2 4) chain A residue 138 type sequence S description binding site for residue MG A 202 source : AC2 5) chain A residue 124 type sequence H description binding site for residue MG A 203 source : AC3 6) chain A residue 160 type sequence H description binding site for residue MG A 204 source : AC4 7) chain A residue 142 type sequence D description binding site for residue MG A 205 source : AC5 8) chain A residue 163 type sequence H description binding site for residue MG A 205 source : AC5 9) chain A residue 18 type sequence N description binding site for residue MG A 206 source : AC6 10) chain A residue 70 type sequence D description binding site for residue MG A 206 source : AC6 11) chain A residue 87 type sequence D description binding site for residue MG A 207 source : AC7 12) chain A residue 120 type sequence E description binding site for residue MG A 208 source : AC8 13) chain A residue 43 type sequence G description binding site for residue CL A 209 source : AC9 14) chain A residue 45 type sequence H description binding site for residue CL A 209 source : AC9 15) chain A residue 46 type sequence T description binding site for residue CL A 209 source : AC9 16) chain A residue 96 type sequence G description binding site for residue CL A 209 source : AC9 17) chain A residue 5 type sequence I description binding site for residue DHF A 210 source : AD1 18) chain A residue 6 type sequence A description binding site for residue DHF A 210 source : AD1 19) chain A residue 7 type sequence A description binding site for residue DHF A 210 source : AD1 20) chain A residue 16 type sequence M description binding site for residue DHF A 210 source : AD1 21) chain A residue 20 type sequence M description binding site for residue DHF A 210 source : AD1 22) chain A residue 27 type sequence D description binding site for residue DHF A 210 source : AD1 23) chain A residue 31 type sequence F description binding site for residue DHF A 210 source : AD1 24) chain A residue 32 type sequence K description binding site for residue DHF A 210 source : AD1 25) chain A residue 57 type sequence R description binding site for residue DHF A 210 source : AD1 26) chain A residue 94 type sequence I description binding site for residue DHF A 210 source : AD1 27) chain A residue 100 type sequence Y description binding site for residue DHF A 210 source : AD1 28) chain A residue 113 type sequence T description binding site for residue DHF A 210 source : AD1 29) chain A residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 13-35 type prosite sequence VIGMENAMPWNLPADLAWFKRNT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT source prosite : PS00075

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