eF-site ID 6cwy-C PDB Code 6cwy Chain C click to enlarge Title Crystal structure of SUMO E1 in complex with an allosteric inhibitor Classification transferase/transferase inhibitor Compound SUMO-activating enzyme subunit 1 Source (SAE2_HUMAN) Sequence C:  AQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLI LAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASL ERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSR DVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVE EKTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFL LQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGI SPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRD PPHNNFFFFDGMKGNGIVECLGPK Description Functional site 1) chain C residue 162 type sequence H description binding site for residue GOL C 401 source : AC1 2) chain C residue 288 type sequence P description binding site for residue GOL C 401 source : AC1 3) chain C residue 291 type sequence F description binding site for residue GOL C 401 source : AC1 4) chain C residue 294 type sequence Y description binding site for residue GOL C 401 source : AC1 5) chain C residue 42 type sequence V description binding site for residue GOL C 402 source : AC2 6) chain C residue 67 type sequence D description binding site for residue GOL C 402 source : AC2 7) chain C residue 68 type sequence H description binding site for residue GOL C 402 source : AC2 8) chain C residue 69 type sequence E description binding site for residue GOL C 402 source : AC2 9) chain C residue 114 type sequence D description binding site for residue GOL C 402 source : AC2 10) chain C residue 115 type sequence I description binding site for residue GOL C 402 source : AC2 11) chain C residue 79 type sequence Q description binding site for residue FHJ D 707 source : AC9

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