eF-site ID 6cwg-ABCD PDB Code 6cwg Chain A, B, C, D click to enlarge Title Ricin catalytic subunit bound go A9 VHH antibody Classification IMMUNE SYSTEM Compound Ricin Source (6CWG) Sequence A:  QYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPV LPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGY RAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYD RLEQLAGNLRENIELGNGPLEEAISALYYYSTGTQLPTLA RSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVI TLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDV SILIPIIALMVYRCAPPPSSQF B:  QLAESGGGLVQAGGSLKLSCAASGRDFSMYMLAWFRQAPG KEREFVAAIMCSGGGGGTYYADSMQGRFTISRDNAKKTVA LQMNSLKPEDTAVYYCAASTTYCSATTYSSDRLYDFWGQG TQVTVSS C:  QYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPV LPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGY RAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYD RLEQLAGNLRENIELGNGPLEEAISALYYYSTGTQLPTLA RSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVI TLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDV SILIPIIALMVYRCAPPPS D:  QLAESGGGLVQAGGSLKLSCAASGRDFSMYMLAWFRQAPG KEREFVAAIMCSGGGGGTYYADSMQGRFTISRDNAKKTVA LQMNSLKPEDTAVYYCAASTTYCSATTYSSDRLYDFWGQG TQVTVSS Description (1)  Ricin (E.C.3.2.2.22), VHH antibody Functional site 1) chain A residue 172-188 type prosite sequence IQMISEAARFQYIEGEM description SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMIsEAARFQyIEgeM source prosite : PS00275 2) chain C residue 15 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 3) chain C residue 50 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 4) chain C residue 141 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 5) chain C residue 195 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 6) chain A residue 141 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 7) chain A residue 195 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 8) chain A residue 15 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 9) chain A residue 50 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 10) chain A residue 236 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:1368517 source Swiss-Prot : SWS_FT_FI6 11) chain C residue 236 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:1368517 source Swiss-Prot : SWS_FT_FI6 12) chain C residue 80 type ACT_SITE sequence Y description ACT_SITE => ECO:0000250|UniProtKB:P84531 source Swiss-Prot : SWS_FT_FI1 13) chain C residue 123 type ACT_SITE sequence Y description ACT_SITE => ECO:0000250|UniProtKB:P84531 source Swiss-Prot : SWS_FT_FI1 14) chain C residue 177 type ACT_SITE sequence E description ACT_SITE => ECO:0000250|UniProtKB:P84531 source Swiss-Prot : SWS_FT_FI1 15) chain C residue 180 type ACT_SITE sequence R description ACT_SITE => ECO:0000250|UniProtKB:P84531 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 80 type ACT_SITE sequence Y description ACT_SITE => ECO:0000250|UniProtKB:P84531 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 123 type ACT_SITE sequence Y description ACT_SITE => ECO:0000250|UniProtKB:P84531 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 177 type ACT_SITE sequence E description ACT_SITE => ECO:0000250|UniProtKB:P84531 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 180 type ACT_SITE sequence R description ACT_SITE => ECO:0000250|UniProtKB:P84531 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 80 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:8780513, ECO:0007744|PDB:1OBT source Swiss-Prot : SWS_FT_FI4 21) chain C residue 121 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8780513, ECO:0007744|PDB:1OBT source Swiss-Prot : SWS_FT_FI4 22) chain A residue 80 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:8780513, ECO:0007744|PDB:1OBT source Swiss-Prot : SWS_FT_FI4 23) chain A residue 121 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8780513, ECO:0007744|PDB:1OBT source Swiss-Prot : SWS_FT_FI4 24) chain A residue 10 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1368517 source Swiss-Prot : SWS_FT_FI5 25) chain C residue 10 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1368517 source Swiss-Prot : SWS_FT_FI5 26) chain A residue 8 type BINDING sequence I description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 27) chain C residue 8 type BINDING sequence I description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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