eF-site ID 6ct7-ABHL PDB Code 6ct7 Chain A, B, H, L click to enlarge Title Fab of anti-a-synuclein antibody BIIB054 in complex with acetylated a-synuclein peptide (1-10) Classification IMMUNE SYSTEM Compound BIIB054 Fab light chain Source (6CT7) Sequence A:  EVQLVESGGGLVEPGGSLRLSCAVSGFDFEKAWMSWVRQA PGQGLQWVARIKSTADGGTTSYAAPVEGRFIISRDDSRNM LYLQMNSLKTEDTAVYYCTSAHWGQGTLVTVSSASTKGPS VFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTF PAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK VDKRVEPK B:  SYELTQPPSVSVSPGQTARITCSGEALPMQFAHWYQQRPG KAPVIVVYKDSERPSGVPERFSGSSSGTTATLTITGVQAE DEADYYCQSPDSTNTYEVFGGGTKLTVLSQPKAAPSVTLF PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG VETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHE GSTVEKTVAPT H:  EVQLVESGGGLVEPGGSLRLSCAVSGFDFEKAWMSWVRQA PGQGLQWVARIKSTADGGTTSYAAPVEGRFIISRDDSRNM LYLQMNSLKTEDTAVYYCTSAHWGQGTLVTVSSASTKGPS VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH KPSNTKVDKRVEPK L:  SYELTQPPSVSVSPGQTARITCSGEALPMQFAHWYQQRPG KAPVIVVYKDSERPSGVPERFSGSSSGTTATLTITGVQAE DEADYYCQSPDSTNTYEVFGGGTKLTVLSQPKAAPSVTLF PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG VETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHE GSTVEKTVAPTE Description (1)  BIIB054 Fab light chain, BIIB054 Fab heavy chain, ACE-MET-ASP-VAL-PHE-MET-LYS-GLY-LEU-SER-LYS Functional site 1) chain L residue 36 type sequence Q description binding site for residue IPA L 301 source : AC1 2) chain L residue 46 type sequence V description binding site for residue IPA L 301 source : AC1 3) chain L residue 84 type sequence D description binding site for residue IPA L 302 source : AC2 4) chain L residue 101 type sequence G description binding site for residue IPA L 302 source : AC2 5) chain A residue 105 type sequence Q description binding site for residue IPA H 301 source : AC3 6) chain H residue 2 type sequence V description binding site for residue IPA H 301 source : AC3 7) chain B residue 86 type sequence Y description binding site for residue IPA B 301 source : AC4 8) chain B residue 101 type sequence G description binding site for residue IPA B 301 source : AC4 9) chain B residue 102 type sequence G description binding site for residue IPA B 301 source : AC4 10) chain A residue 27 type sequence F description binding site for Di-peptide ACE T 0 and MET T 1 source : AC5 11) chain A residue 102 type sequence H description binding site for Di-peptide ACE T 0 and MET T 1 source : AC5 12) chain H residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH source prosite : PS00290 13) chain L residue 193-199 type prosite sequence YSCQVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH source prosite : PS00290

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