eF-site ID 6coy-B PDB Code 6coy Chain B click to enlarge Title Human CLC-1 chloride ion channel, transmembrane domain Classification TRANSPORT PROTEIN Compound Chloride channel protein 1 Source (CLCN1_HUMAN) Sequence B:  EDGIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQP SLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMK TILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPF VHIASICAAVLSKFMYYSDILTVGCAVGVGCCFGTPLGGV LFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDA VTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFV YLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTF PPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESLGQS AVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMP VFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAV IGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILA NMVAQSLQPSLYDSIIQVKKLPYLP Description Functional site 1) chain B residue 230 type sequence G description binding site for residue CL B 1001 source : AC3 2) chain B residue 231 type sequence K description binding site for residue CL B 1001 source : AC3 3) chain B residue 232 type sequence E description binding site for residue CL B 1001 source : AC3 4) chain B residue 233 type sequence G description binding site for residue CL B 1001 source : AC3 5) chain B residue 484 type sequence F description binding site for residue CL B 1001 source : AC3 6) chain B residue 485 type sequence M description binding site for residue CL B 1001 source : AC3 7) chain B residue 189 type sequence S description binding site for residue CL B 1002 source : AC4 8) chain B residue 581 type sequence I description binding site for residue CL B 1002 source : AC4 9) chain B residue 189 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P37019 source Swiss-Prot : SWS_FT_FI5 10) chain B residue 484 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P37019 source Swiss-Prot : SWS_FT_FI5 11) chain B residue 578 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P37019 source Swiss-Prot : SWS_FT_FI5 12) chain B residue 196-208 type TOPO_DOM sequence TILRGVVLKEYLT description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 247-268 type TOPO_DOM sequence SKFMYYSDILT description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 291-301 type TOPO_DOM sequence EVTSTYFAVRN description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 377-390 type TOPO_DOM sequence RKHKALSQFLAKHR description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 180-183 type TOPO_DOM sequence HLIS description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 119-150 type TRANSMEM sequence IFLVLLGLLMALVSWSMDYVSAKSLQAYKWSY description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 18) chain B residue 159-179 type TRANSMEM sequence LQFLVWVTFPLVLILFSALFC description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 209-228 type TRANSMEM sequence MKAFVAKVVALTAGLGSGIP description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 229-246 type TRANSMEM sequence VGKEGPFVHIASICAAVL description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 302-321 type TRANSMEM sequence YWRGFFAATFSAFVFRVLAV description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 348-376 type TRANSMEM sequence LPAFAAIGICCGLLGAVFVYLHRQVMLGV description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 391-408 type TRANSMEM sequence LLYPGIVTFVIASFTFPP description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 458-478 type TRANSMEM sequence IIIFLFFVMKFWMSIVATTMP description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 479-498 type TRANSMEM sequence IPCGGFMPVFVLGAAFGRLV description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 558-578 type TRANSMEM sequence PMMVAVILANMVAQSLQPSLY description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 427-457 type TOPO_DOM sequence LFDNNTWVKHAGDPESLGQSAVWIHPRVNVV description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 499-521 type TOPO_DOM sequence GEIMAMLFPDGILFDDIIYKILP description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 29) chain B residue 555-557 type TOPO_DOM sequence HIL description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 151-158 type TOPO_DOM sequence AQMQPSLP description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 322-347 type TOPO_DOM sequence WNKDAVTITALFRTNFRMDFPFDLKE description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 32) chain B residue 409-414 type TOPO_DOM sequence GMGQFM description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 33) chain B residue 184-195 type INTRAMEM sequence PQAVGSGIPEMK description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI4 34) chain B residue 269-290 type INTRAMEM sequence VGCAVGVGCCFGTPLGGVLFSI description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI4 35) chain B residue 415-426 type INTRAMEM sequence AGELMPREAIST description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 522-554 type INTRAMEM sequence GGYAVIGAAALTGAVSHTVSTAVICFELTGQIA description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links