eF-site ID 6coy-A PDB Code 6coy Chain A click to enlarge Title Human CLC-1 chloride ion channel, transmembrane domain Classification TRANSPORT PROTEIN Compound Chloride channel protein 1 Source (CLCN1_HUMAN) Sequence A:  EDGIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQP SLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMK TILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPF VHIASICAAVLSKFMYYSDILTVGCAVGVGCCFGTPLGGV LFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDA VTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFV YLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTF PPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESLGQS AVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMP VFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAV IGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILA NMVAQSLQPSLYDSIIQVKKLPYLP Description Functional site 1) chain A residue 230 type sequence G description binding site for residue CL A 1001 source : AC1 2) chain A residue 231 type sequence K description binding site for residue CL A 1001 source : AC1 3) chain A residue 232 type sequence E description binding site for residue CL A 1001 source : AC1 4) chain A residue 233 type sequence G description binding site for residue CL A 1001 source : AC1 5) chain A residue 484 type sequence F description binding site for residue CL A 1001 source : AC1 6) chain A residue 485 type sequence M description binding site for residue CL A 1001 source : AC1 7) chain A residue 189 type sequence S description binding site for residue CL A 1002 source : AC2 8) chain A residue 581 type sequence I description binding site for residue CL A 1002 source : AC2 9) chain A residue 189 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P37019 source Swiss-Prot : SWS_FT_FI5 10) chain A residue 484 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P37019 source Swiss-Prot : SWS_FT_FI5 11) chain A residue 578 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P37019 source Swiss-Prot : SWS_FT_FI5 12) chain A residue 180-183 type TOPO_DOM sequence HLIS description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 196-208 type TOPO_DOM sequence TILRGVVLKEYLT description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 247-268 type TOPO_DOM sequence SKFMYYSDILT description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 291-301 type TOPO_DOM sequence EVTSTYFAVRN description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 377-390 type TOPO_DOM sequence RKHKALSQFLAKHR description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 119-150 type TRANSMEM sequence IFLVLLGLLMALVSWSMDYVSAKSLQAYKWSY description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 558-578 type TRANSMEM sequence PMMVAVILANMVAQSLQPSLY description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 159-179 type TRANSMEM sequence LQFLVWVTFPLVLILFSALFC description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 209-228 type TRANSMEM sequence MKAFVAKVVALTAGLGSGIP description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 229-246 type TRANSMEM sequence VGKEGPFVHIASICAAVL description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 302-321 type TRANSMEM sequence YWRGFFAATFSAFVFRVLAV description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 348-376 type TRANSMEM sequence LPAFAAIGICCGLLGAVFVYLHRQVMLGV description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 391-408 type TRANSMEM sequence LLYPGIVTFVIASFTFPP description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 458-478 type TRANSMEM sequence IIIFLFFVMKFWMSIVATTMP description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 479-498 type TRANSMEM sequence IPCGGFMPVFVLGAAFGRLV description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 151-158 type TOPO_DOM sequence AQMQPSLP description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 322-347 type TOPO_DOM sequence WNKDAVTITALFRTNFRMDFPFDLKE description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 409-414 type TOPO_DOM sequence GMGQFM description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 427-457 type TOPO_DOM sequence LFDNNTWVKHAGDPESLGQSAVWIHPRVNVV description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 499-521 type TOPO_DOM sequence GEIMAMLFPDGILFDDIIYKILP description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 555-557 type TOPO_DOM sequence HIL description Extracellular => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 33) chain A residue 184-195 type INTRAMEM sequence PQAVGSGIPEMK description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 269-290 type INTRAMEM sequence VGCAVGVGCCFGTPLGGVLFSI description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 415-426 type INTRAMEM sequence AGELMPREAIST description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI4 36) chain A residue 522-554 type INTRAMEM sequence GGYAVIGAAALTGAVSHTVSTAVICFELTGQIA description Helical => ECO:0000269|PubMed:29809153 source Swiss-Prot : SWS_FT_FI4

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