eF-site/Summary 6cm2-ABCD

eF-site ID	6cm2-ABCD
PDB Code	6cm2
Chain	A, B, C, D

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Title	SAMHD1 HD domain bound to decitabine triphosphate
Classification	HYDROLASE
Compound	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Source	(SAMH1_HUMAN)

Sequence	A:	TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGG YYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISE RDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTH EQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIV GPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNL YDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEI TGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLK DAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKE VASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDR KSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
	B:	DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGG GYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQIS ERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWT HEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQI VGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGN LYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIE ITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKL KDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPK EVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVD RKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEW N
	C:	DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGG GYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQIS ERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWT HEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQI VGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGN LYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIE ITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKL KDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPK EVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVD RKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEW N
	D:	DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGG GYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQIS ERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWT HEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQI VGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGN LYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIE ITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKL KDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPK EVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVD RKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEW N

Description

Functional site


1)	chain	D
	residue	149
	type
	sequence	Q
	description	binding site for residue F6G D 701
	source	: AC1

2)	chain	D
	residue	150
	type
	sequence	L
	description	binding site for residue F6G D 701
	source	: AC1

3)	chain	D
	residue	164
	type
	sequence	R
	description	binding site for residue F6G D 701
	source	: AC1

4)	chain	D
	residue	206
	type
	sequence	R
	description	binding site for residue F6G D 701
	source	: AC1

5)	chain	D
	residue	215
	type
	sequence	H
	description	binding site for residue F6G D 701
	source	: AC1

6)	chain	D
	residue	233
	type
	sequence	H
	description	binding site for residue F6G D 701
	source	: AC1

7)	chain	D
	residue	312
	type
	sequence	K
	description	binding site for residue F6G D 701
	source	: AC1

8)	chain	D
	residue	315
	type
	sequence	Y
	description	binding site for residue F6G D 701
	source	: AC1

9)	chain	D
	residue	319
	type
	sequence	D
	description	binding site for residue F6G D 701
	source	: AC1

10)	chain	D
	residue	366
	type
	sequence	R
	description	binding site for residue F6G D 701
	source	: AC1

11)	chain	D
	residue	370
	type
	sequence	H
	description	binding site for residue F6G D 701
	source	: AC1

12)	chain	D
	residue	374
	type
	sequence	Y
	description	binding site for residue F6G D 701
	source	: AC1

13)	chain	D
	residue	375
	type
	sequence	Q
	description	binding site for residue F6G D 701
	source	: AC1

14)	chain	A
	residue	116
	type
	sequence	K
	description	binding site for residue GTP D 702
	source	: AC2

15)	chain	A
	residue	117
	type
	sequence	V
	description	binding site for residue GTP D 702
	source	: AC2

16)	chain	A
	residue	118
	type
	sequence	I
	description	binding site for residue GTP D 702
	source	: AC2

17)	chain	A
	residue	137
	type
	sequence	D
	description	binding site for residue GTP D 702
	source	: AC2

18)	chain	A
	residue	142
	type
	sequence	Q
	description	binding site for residue GTP D 702
	source	: AC2

19)	chain	A
	residue	145
	type
	sequence	R
	description	binding site for residue GTP D 702
	source	: AC2

20)	chain	A
	residue	165
	type
	sequence	F
	description	binding site for residue GTP D 702
	source	: AC2

21)	chain	B
	residue	523
	type
	sequence	K
	description	binding site for residue GTP D 702
	source	: AC2

22)	chain	D
	residue	155
	type
	sequence	Y
	description	binding site for residue GTP D 702
	source	: AC2

23)	chain	D
	residue	156
	type
	sequence	V
	description	binding site for residue GTP D 702
	source	: AC2

24)	chain	D
	residue	451
	type
	sequence	R
	description	binding site for residue GTP D 702
	source	: AC2

25)	chain	D
	residue	455
	type
	sequence	K
	description	binding site for residue GTP D 702
	source	: AC2

26)	chain	B
	residue	156
	type
	sequence	V
	description	binding site for residue F6G D 703
	source	: AC3

27)	chain	B
	residue	157
	type
	sequence	F
	description	binding site for residue F6G D 703
	source	: AC3

28)	chain	B
	residue	372
	type
	sequence	R
	description	binding site for residue F6G D 703
	source	: AC3

29)	chain	B
	residue	376
	type
	sequence	H
	description	binding site for residue F6G D 703
	source	: AC3

30)	chain	B
	residue	377
	type
	sequence	K
	description	binding site for residue F6G D 703
	source	: AC3

31)	chain	C
	residue	117
	type
	sequence	V
	description	binding site for residue F6G D 703
	source	: AC3

32)	chain	C
	residue	118
	type
	sequence	I
	description	binding site for residue F6G D 703
	source	: AC3

33)	chain	C
	residue	119
	type
	sequence	N
	description	binding site for residue F6G D 703
	source	: AC3

34)	chain	D
	residue	333
	type
	sequence	R
	description	binding site for residue F6G D 703
	source	: AC3

35)	chain	D
	residue	337
	type
	sequence	F
	description	binding site for residue F6G D 703
	source	: AC3

36)	chain	D
	residue	352
	type
	sequence	R
	description	binding site for residue F6G D 703
	source	: AC3

37)	chain	D
	residue	354
	type
	sequence	K
	description	binding site for residue F6G D 703
	source	: AC3

38)	chain	D
	residue	523
	type
	sequence	K
	description	binding site for residue F6G D 703
	source	: AC3

39)	chain	C
	residue	149
	type
	sequence	Q
	description	binding site for residue F6G C 701
	source	: AC4

40)	chain	C
	residue	150
	type
	sequence	L
	description	binding site for residue F6G C 701
	source	: AC4

41)	chain	C
	residue	164
	type
	sequence	R
	description	binding site for residue F6G C 701
	source	: AC4

42)	chain	C
	residue	206
	type
	sequence	R
	description	binding site for residue F6G C 701
	source	: AC4

43)	chain	C
	residue	215
	type
	sequence	H
	description	binding site for residue F6G C 701
	source	: AC4

44)	chain	C
	residue	233
	type
	sequence	H
	description	binding site for residue F6G C 701
	source	: AC4

45)	chain	C
	residue	312
	type
	sequence	K
	description	binding site for residue F6G C 701
	source	: AC4

46)	chain	C
	residue	315
	type
	sequence	Y
	description	binding site for residue F6G C 701
	source	: AC4

47)	chain	C
	residue	319
	type
	sequence	D
	description	binding site for residue F6G C 701
	source	: AC4

48)	chain	C
	residue	366
	type
	sequence	R
	description	binding site for residue F6G C 701
	source	: AC4

49)	chain	C
	residue	370
	type
	sequence	H
	description	binding site for residue F6G C 701
	source	: AC4

50)	chain	C
	residue	374
	type
	sequence	Y
	description	binding site for residue F6G C 701
	source	: AC4

51)	chain	C
	residue	375
	type
	sequence	Q
	description	binding site for residue F6G C 701
	source	: AC4

52)	chain	C
	residue	116
	type
	sequence	K
	description	binding site for residue MG C 702
	source	: AC5

53)	chain	A
	residue	156
	type
	sequence	V
	description	binding site for residue F6G C 703
	source	: AC6

54)	chain	A
	residue	157
	type
	sequence	F
	description	binding site for residue F6G C 703
	source	: AC6

55)	chain	A
	residue	372
	type
	sequence	R
	description	binding site for residue F6G C 703
	source	: AC6

56)	chain	A
	residue	376
	type
	sequence	H
	description	binding site for residue F6G C 703
	source	: AC6

57)	chain	A
	residue	377
	type
	sequence	K
	description	binding site for residue F6G C 703
	source	: AC6

58)	chain	C
	residue	333
	type
	sequence	R
	description	binding site for residue F6G C 703
	source	: AC6

59)	chain	C
	residue	337
	type
	sequence	F
	description	binding site for residue F6G C 703
	source	: AC6

60)	chain	C
	residue	352
	type
	sequence	R
	description	binding site for residue F6G C 703
	source	: AC6

61)	chain	C
	residue	354
	type
	sequence	K
	description	binding site for residue F6G C 703
	source	: AC6

62)	chain	C
	residue	523
	type
	sequence	K
	description	binding site for residue F6G C 703
	source	: AC6

63)	chain	D
	residue	117
	type
	sequence	V
	description	binding site for residue F6G C 703
	source	: AC6

64)	chain	D
	residue	119
	type
	sequence	N
	description	binding site for residue F6G C 703
	source	: AC6

65)	chain	D
	residue	116
	type
	sequence	K
	description	binding site for residue MG C 704
	source	: AC7

66)	chain	A
	residue	117
	type
	sequence	V
	description	binding site for residue F6G B 701
	source	: AC8

67)	chain	A
	residue	119
	type
	sequence	N
	description	binding site for residue F6G B 701
	source	: AC8

68)	chain	B
	residue	333
	type
	sequence	R
	description	binding site for residue F6G B 701
	source	: AC8

69)	chain	B
	residue	337
	type
	sequence	F
	description	binding site for residue F6G B 701
	source	: AC8

70)	chain	B
	residue	352
	type
	sequence	R
	description	binding site for residue F6G B 701
	source	: AC8

71)	chain	B
	residue	354
	type
	sequence	K
	description	binding site for residue F6G B 701
	source	: AC8

72)	chain	B
	residue	523
	type
	sequence	K
	description	binding site for residue F6G B 701
	source	: AC8

73)	chain	D
	residue	156
	type
	sequence	V
	description	binding site for residue F6G B 701
	source	: AC8

74)	chain	D
	residue	157
	type
	sequence	F
	description	binding site for residue F6G B 701
	source	: AC8

75)	chain	D
	residue	372
	type
	sequence	R
	description	binding site for residue F6G B 701
	source	: AC8

76)	chain	D
	residue	376
	type
	sequence	H
	description	binding site for residue F6G B 701
	source	: AC8

77)	chain	D
	residue	377
	type
	sequence	K
	description	binding site for residue F6G B 701
	source	: AC8

78)	chain	D
	residue	378
	type
	sequence	V
	description	binding site for residue F6G B 701
	source	: AC8

79)	chain	B
	residue	523
	type
	sequence	K
	description	binding site for residue MG B 702
	source	: AC9

80)	chain	A
	residue	523
	type
	sequence	K
	description	binding site for residue GTP B 703
	source	: AD1

81)	chain	B
	residue	116
	type
	sequence	K
	description	binding site for residue GTP B 703
	source	: AD1

82)	chain	B
	residue	117
	type
	sequence	V
	description	binding site for residue GTP B 703
	source	: AD1

83)	chain	B
	residue	118
	type
	sequence	I
	description	binding site for residue GTP B 703
	source	: AD1

84)	chain	B
	residue	136
	type
	sequence	I
	description	binding site for residue GTP B 703
	source	: AD1

85)	chain	B
	residue	137
	type
	sequence	D
	description	binding site for residue GTP B 703
	source	: AD1

86)	chain	B
	residue	142
	type
	sequence	Q
	description	binding site for residue GTP B 703
	source	: AD1

87)	chain	B
	residue	145
	type
	sequence	R
	description	binding site for residue GTP B 703
	source	: AD1

88)	chain	B
	residue	165
	type
	sequence	F
	description	binding site for residue GTP B 703
	source	: AD1

89)	chain	C
	residue	155
	type
	sequence	Y
	description	binding site for residue GTP B 703
	source	: AD1

90)	chain	C
	residue	156
	type
	sequence	V
	description	binding site for residue GTP B 703
	source	: AD1

91)	chain	C
	residue	451
	type
	sequence	R
	description	binding site for residue GTP B 703
	source	: AD1

92)	chain	C
	residue	455
	type
	sequence	K
	description	binding site for residue GTP B 703
	source	: AD1

93)	chain	B
	residue	149
	type
	sequence	Q
	description	binding site for residue F6G B 704
	source	: AD2

94)	chain	B
	residue	150
	type
	sequence	L
	description	binding site for residue F6G B 704
	source	: AD2

95)	chain	B
	residue	164
	type
	sequence	R
	description	binding site for residue F6G B 704
	source	: AD2

96)	chain	B
	residue	206
	type
	sequence	R
	description	binding site for residue F6G B 704
	source	: AD2

97)	chain	B
	residue	215
	type
	sequence	H
	description	binding site for residue F6G B 704
	source	: AD2

98)	chain	B
	residue	233
	type
	sequence	H
	description	binding site for residue F6G B 704
	source	: AD2

99)	chain	B
	residue	312
	type
	sequence	K
	description	binding site for residue F6G B 704
	source	: AD2

100)	chain	B
	residue	315
	type
	sequence	Y
	description	binding site for residue F6G B 704
	source	: AD2

101)	chain	B
	residue	319
	type
	sequence	D
	description	binding site for residue F6G B 704
	source	: AD2

102)	chain	B
	residue	366
	type
	sequence	R
	description	binding site for residue F6G B 704
	source	: AD2

103)	chain	B
	residue	370
	type
	sequence	H
	description	binding site for residue F6G B 704
	source	: AD2

104)	chain	B
	residue	374
	type
	sequence	Y
	description	binding site for residue F6G B 704
	source	: AD2

105)	chain	B
	residue	375
	type
	sequence	Q
	description	binding site for residue F6G B 704
	source	: AD2

106)	chain	B
	residue	155
	type
	sequence	Y
	description	binding site for residue GTP B 705
	source	: AD3

107)	chain	B
	residue	156
	type
	sequence	V
	description	binding site for residue GTP B 705
	source	: AD3

108)	chain	B
	residue	378
	type
	sequence	V
	description	binding site for residue GTP B 705
	source	: AD3

109)	chain	B
	residue	451
	type
	sequence	R
	description	binding site for residue GTP B 705
	source	: AD3

110)	chain	B
	residue	455
	type
	sequence	K
	description	binding site for residue GTP B 705
	source	: AD3

111)	chain	C
	residue	116
	type
	sequence	K
	description	binding site for residue GTP B 705
	source	: AD3

112)	chain	C
	residue	117
	type
	sequence	V
	description	binding site for residue GTP B 705
	source	: AD3

113)	chain	C
	residue	118
	type
	sequence	I
	description	binding site for residue GTP B 705
	source	: AD3

114)	chain	C
	residue	137
	type
	sequence	D
	description	binding site for residue GTP B 705
	source	: AD3

115)	chain	C
	residue	142
	type
	sequence	Q
	description	binding site for residue GTP B 705
	source	: AD3

116)	chain	C
	residue	145
	type
	sequence	R
	description	binding site for residue GTP B 705
	source	: AD3

117)	chain	C
	residue	165
	type
	sequence	F
	description	binding site for residue GTP B 705
	source	: AD3

118)	chain	D
	residue	523
	type
	sequence	K
	description	binding site for residue GTP B 705
	source	: AD3

119)	chain	A
	residue	333
	type
	sequence	R
	description	binding site for residue F6G A 701
	source	: AD4

120)	chain	A
	residue	337
	type
	sequence	F
	description	binding site for residue F6G A 701
	source	: AD4

121)	chain	A
	residue	352
	type
	sequence	R
	description	binding site for residue F6G A 701
	source	: AD4

122)	chain	A
	residue	354
	type
	sequence	K
	description	binding site for residue F6G A 701
	source	: AD4

123)	chain	A
	residue	523
	type
	sequence	K
	description	binding site for residue F6G A 701
	source	: AD4

124)	chain	B
	residue	117
	type
	sequence	V
	description	binding site for residue F6G A 701
	source	: AD4

125)	chain	B
	residue	119
	type
	sequence	N
	description	binding site for residue F6G A 701
	source	: AD4

126)	chain	C
	residue	156
	type
	sequence	V
	description	binding site for residue F6G A 701
	source	: AD4

127)	chain	C
	residue	157
	type
	sequence	F
	description	binding site for residue F6G A 701
	source	: AD4

128)	chain	C
	residue	372
	type
	sequence	R
	description	binding site for residue F6G A 701
	source	: AD4

129)	chain	C
	residue	376
	type
	sequence	H
	description	binding site for residue F6G A 701
	source	: AD4

130)	chain	C
	residue	377
	type
	sequence	K
	description	binding site for residue F6G A 701
	source	: AD4

131)	chain	C
	residue	378
	type
	sequence	V
	description	binding site for residue F6G A 701
	source	: AD4

132)	chain	A
	residue	149
	type
	sequence	Q
	description	binding site for residue F6G A 703
	source	: AD6

133)	chain	A
	residue	150
	type
	sequence	L
	description	binding site for residue F6G A 703
	source	: AD6

134)	chain	A
	residue	164
	type
	sequence	R
	description	binding site for residue F6G A 703
	source	: AD6

135)	chain	A
	residue	206
	type
	sequence	R
	description	binding site for residue F6G A 703
	source	: AD6

136)	chain	A
	residue	215
	type
	sequence	H
	description	binding site for residue F6G A 703
	source	: AD6

137)	chain	A
	residue	233
	type
	sequence	H
	description	binding site for residue F6G A 703
	source	: AD6

138)	chain	A
	residue	311
	type
	sequence	D
	description	binding site for residue F6G A 703
	source	: AD6

139)	chain	A
	residue	312
	type
	sequence	K
	description	binding site for residue F6G A 703
	source	: AD6

140)	chain	A
	residue	315
	type
	sequence	Y
	description	binding site for residue F6G A 703
	source	: AD6

141)	chain	A
	residue	319
	type
	sequence	D
	description	binding site for residue F6G A 703
	source	: AD6

142)	chain	A
	residue	366
	type
	sequence	R
	description	binding site for residue F6G A 703
	source	: AD6

143)	chain	A
	residue	370
	type
	sequence	H
	description	binding site for residue F6G A 703
	source	: AD6

144)	chain	A
	residue	374
	type
	sequence	Y
	description	binding site for residue F6G A 703
	source	: AD6

145)	chain	A
	residue	375
	type
	sequence	Q
	description	binding site for residue F6G A 703
	source	: AD6

146)	chain	A
	residue	155
	type
	sequence	Y
	description	binding site for residue GTP A 704
	source	: AD7

147)	chain	A
	residue	156
	type
	sequence	V
	description	binding site for residue GTP A 704
	source	: AD7

148)	chain	A
	residue	451
	type
	sequence	R
	description	binding site for residue GTP A 704
	source	: AD7

149)	chain	A
	residue	455
	type
	sequence	K
	description	binding site for residue GTP A 704
	source	: AD7

150)	chain	C
	residue	523
	type
	sequence	K
	description	binding site for residue GTP A 704
	source	: AD7

151)	chain	D
	residue	116
	type
	sequence	K
	description	binding site for residue GTP A 704
	source	: AD7

152)	chain	D
	residue	117
	type
	sequence	V
	description	binding site for residue GTP A 704
	source	: AD7

153)	chain	D
	residue	118
	type
	sequence	I
	description	binding site for residue GTP A 704
	source	: AD7

154)	chain	D
	residue	137
	type
	sequence	D
	description	binding site for residue GTP A 704
	source	: AD7

155)	chain	D
	residue	142
	type
	sequence	Q
	description	binding site for residue GTP A 704
	source	: AD7

156)	chain	D
	residue	145
	type
	sequence	R
	description	binding site for residue GTP A 704
	source	: AD7

157)	chain	D
	residue	165
	type
	sequence	F
	description	binding site for residue GTP A 704
	source	: AD7

158)	chain	D
	residue	592
	type	MOD_RES
	sequence	T
	description	Phosphothreonine; by CDK1 => ECO:0000269\|PubMed:23601106, ECO:0000269\|PubMed:23602554, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200, ECO:0000269\|PubMed:29610582, ECO:0000269\|PubMed:29670289, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569
	source	Swiss-Prot : SWS_FT_FI6

159)	chain	C
	residue	592
	type	MOD_RES
	sequence	T
	description	Phosphothreonine; by CDK1 => ECO:0000269\|PubMed:23601106, ECO:0000269\|PubMed:23602554, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200, ECO:0000269\|PubMed:29610582, ECO:0000269\|PubMed:29670289, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569
	source	Swiss-Prot : SWS_FT_FI6

160)	chain	B
	residue	592
	type	MOD_RES
	sequence	T
	description	Phosphothreonine; by CDK1 => ECO:0000269\|PubMed:23601106, ECO:0000269\|PubMed:23602554, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200, ECO:0000269\|PubMed:29610582, ECO:0000269\|PubMed:29670289, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569
	source	Swiss-Prot : SWS_FT_FI6

161)	chain	A
	residue	592
	type	MOD_RES
	sequence	T
	description	Phosphothreonine; by CDK1 => ECO:0000269\|PubMed:23601106, ECO:0000269\|PubMed:23602554, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200, ECO:0000269\|PubMed:29610582, ECO:0000269\|PubMed:29670289, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569
	source	Swiss-Prot : SWS_FT_FI6

162)	chain	D
	residue	233
	type	ACT_SITE
	sequence	H
	description	ACT_SITE => ECO:0000305\|PubMed:22056990
	source	Swiss-Prot : SWS_FT_FI1

163)	chain	C
	residue	233
	type	ACT_SITE
	sequence	H
	description	ACT_SITE => ECO:0000305\|PubMed:22056990
	source	Swiss-Prot : SWS_FT_FI1

164)	chain	B
	residue	233
	type	ACT_SITE
	sequence	H
	description	ACT_SITE => ECO:0000305\|PubMed:22056990
	source	Swiss-Prot : SWS_FT_FI1

165)	chain	A
	residue	233
	type	ACT_SITE
	sequence	H
	description	ACT_SITE => ECO:0000305\|PubMed:22056990
	source	Swiss-Prot : SWS_FT_FI1

166)	chain	D
	residue	116
	type	BINDING
	sequence	K
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

167)	chain	C
	residue	352
	type	BINDING
	sequence	R
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

168)	chain	C
	residue	358
	type	BINDING
	sequence	N
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

169)	chain	C
	residue	523
	type	BINDING
	sequence	K
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

170)	chain	B
	residue	116
	type	BINDING
	sequence	K
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

171)	chain	B
	residue	137
	type	BINDING
	sequence	D
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

172)	chain	B
	residue	333
	type	BINDING
	sequence	R
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

173)	chain	B
	residue	352
	type	BINDING
	sequence	R
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

174)	chain	B
	residue	358
	type	BINDING
	sequence	N
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

175)	chain	B
	residue	523
	type	BINDING
	sequence	K
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

176)	chain	A
	residue	116
	type	BINDING
	sequence	K
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

177)	chain	D
	residue	137
	type	BINDING
	sequence	D
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

178)	chain	A
	residue	137
	type	BINDING
	sequence	D
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

179)	chain	A
	residue	333
	type	BINDING
	sequence	R
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

180)	chain	A
	residue	352
	type	BINDING
	sequence	R
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

181)	chain	A
	residue	358
	type	BINDING
	sequence	N
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

182)	chain	A
	residue	523
	type	BINDING
	sequence	K
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

183)	chain	D
	residue	333
	type	BINDING
	sequence	R
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

184)	chain	D
	residue	352
	type	BINDING
	sequence	R
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

185)	chain	D
	residue	358
	type	BINDING
	sequence	N
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

186)	chain	D
	residue	523
	type	BINDING
	sequence	K
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

187)	chain	C
	residue	116
	type	BINDING
	sequence	K
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

188)	chain	C
	residue	137
	type	BINDING
	sequence	D
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

189)	chain	C
	residue	333
	type	BINDING
	sequence	R
	description	in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI2

190)	chain	D
	residue	119
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

191)	chain	C
	residue	455
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

192)	chain	B
	residue	119
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

193)	chain	B
	residue	376
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

194)	chain	B
	residue	377
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

195)	chain	B
	residue	451
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

196)	chain	B
	residue	455
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

197)	chain	A
	residue	119
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

198)	chain	A
	residue	376
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

199)	chain	A
	residue	377
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

200)	chain	A
	residue	451
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

201)	chain	D
	residue	376
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

202)	chain	A
	residue	455
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

203)	chain	D
	residue	377
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

204)	chain	D
	residue	451
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

205)	chain	D
	residue	455
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

206)	chain	C
	residue	119
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

207)	chain	C
	residue	376
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

208)	chain	C
	residue	377
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

209)	chain	C
	residue	451
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI3

210)	chain	D
	residue	149
	type	BINDING
	sequence	Q
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

211)	chain	C
	residue	164
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

212)	chain	C
	residue	210
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

213)	chain	C
	residue	309
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

214)	chain	C
	residue	315
	type	BINDING
	sequence	Y
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

215)	chain	C
	residue	319
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

216)	chain	C
	residue	366
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

217)	chain	C
	residue	370
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

218)	chain	B
	residue	149
	type	BINDING
	sequence	Q
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

219)	chain	B
	residue	164
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

220)	chain	B
	residue	210
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

221)	chain	D
	residue	164
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

222)	chain	B
	residue	309
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

223)	chain	B
	residue	315
	type	BINDING
	sequence	Y
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

224)	chain	B
	residue	319
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

225)	chain	B
	residue	366
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

226)	chain	B
	residue	370
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

227)	chain	A
	residue	149
	type	BINDING
	sequence	Q
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

228)	chain	A
	residue	164
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

229)	chain	A
	residue	210
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

230)	chain	A
	residue	309
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

231)	chain	A
	residue	315
	type	BINDING
	sequence	Y
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

232)	chain	D
	residue	210
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

233)	chain	A
	residue	319
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

234)	chain	A
	residue	366
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

235)	chain	A
	residue	370
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

236)	chain	D
	residue	309
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

237)	chain	D
	residue	315
	type	BINDING
	sequence	Y
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

238)	chain	D
	residue	319
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

239)	chain	D
	residue	366
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

240)	chain	D
	residue	370
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

241)	chain	C
	residue	149
	type	BINDING
	sequence	Q
	description	BINDING => ECO:0000269\|PubMed:24141705
	source	Swiss-Prot : SWS_FT_FI4

242)	chain	D
	residue	167
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

243)	chain	B
	residue	206
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

244)	chain	B
	residue	207
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

245)	chain	B
	residue	311
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

246)	chain	A
	residue	167
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

247)	chain	A
	residue	206
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

248)	chain	A
	residue	207
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

249)	chain	A
	residue	311
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

250)	chain	D
	residue	206
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

251)	chain	D
	residue	207
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

252)	chain	D
	residue	311
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

253)	chain	C
	residue	167
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

254)	chain	C
	residue	206
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

255)	chain	C
	residue	207
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

256)	chain	C
	residue	311
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

257)	chain	B
	residue	167
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200
	source	Swiss-Prot : SWS_FT_FI5

258)	chain	D
	residue	467
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

259)	chain	B
	residue	467
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

260)	chain	B
	residue	469
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

261)	chain	B
	residue	492
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

262)	chain	A
	residue	467
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

263)	chain	A
	residue	469
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

264)	chain	A
	residue	492
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

265)	chain	D
	residue	469
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

266)	chain	D
	residue	492
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

267)	chain	C
	residue	467
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

268)	chain	C
	residue	469
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

269)	chain	C
	residue	492
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7