eF-site ID 6cks-A PDB Code 6cks Chain A click to enlarge Title Crystal Structure of BRD4 with QC4956 Classification GENE REGULATION/INHIBITOR Compound Bromodomain-containing protein 4 Source Homo sapiens (Human) (BRD4_HUMAN) Sequence A:  MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWP FQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNA QECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKIN ELPTEE Description Functional site 1) chain A residue 81 type sequence W description binding site for residue F5Y A 201 source : AC1 2) chain A residue 82 type sequence P description binding site for residue F5Y A 201 source : AC1 3) chain A residue 85 type sequence Q description binding site for residue F5Y A 201 source : AC1 4) chain A residue 86 type sequence P description binding site for residue F5Y A 201 source : AC1 5) chain A residue 87 type sequence V description binding site for residue F5Y A 201 source : AC1 6) chain A residue 88 type sequence D description binding site for residue F5Y A 201 source : AC1 7) chain A residue 91 type sequence K description binding site for residue F5Y A 201 source : AC1 8) chain A residue 92 type sequence L description binding site for residue F5Y A 201 source : AC1 9) chain A residue 140 type sequence N description binding site for residue F5Y A 201 source : AC1 10) chain A residue 146 type sequence I description binding site for residue F5Y A 201 source : AC1 11) chain A residue 80-139 type prosite sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY WNAQECIQDFNTMFTNCYIY description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY source prosite : PS00633 12) chain A residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2

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