eF-site ID 6chw-A PDB Code 6chw Chain A click to enlarge Title Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942. Classification nuclear protein/antagonist Compound Estrogen receptor Source (ESR1_HUMAN) Sequence A:  LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGL LTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLE ILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKSVEGMVEIF DMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSST LKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLA QLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLD AHRLHA Description (1)  Estrogen receptor Functional site 1) chain A residue 346 type sequence L description binding site for residue F3D A 601 source : AC1 2) chain A residue 347 type sequence T description binding site for residue F3D A 601 source : AC1 3) chain A residue 350 type sequence A description binding site for residue F3D A 601 source : AC1 4) chain A residue 353 type sequence E description binding site for residue F3D A 601 source : AC1 5) chain A residue 387 type sequence L description binding site for residue F3D A 601 source : AC1 6) chain A residue 394 type sequence R description binding site for residue F3D A 601 source : AC1 7) chain A residue 521 type sequence G description binding site for residue F3D A 601 source : AC1 8) chain A residue 525 type sequence L description binding site for residue F3D A 601 source : AC1 9) chain A residue 528 type sequence M description binding site for residue F3D A 601 source : AC1 10) chain A residue 529 type sequence K description binding site for residue F3D A 601 source : AC1 11) chain A residue 530 type sequence C description binding site for residue F3D A 601 source : AC1 12) chain A residue 381 type sequence S description binding site for residue EDO A 602 source : AC2 13) chain A residue 382 type sequence A description binding site for residue EDO A 602 source : AC2 14) chain A residue 383 type sequence W description binding site for residue EDO A 602 source : AC2 15) chain A residue 384 type sequence L description binding site for residue EDO A 602 source : AC2 16) chain A residue 385 type sequence E description binding site for residue EDO A 602 source : AC2 17) chain A residue 518 type sequence S description binding site for residue EDO A 602 source : AC2 18) chain A residue 522 type sequence M description binding site for residue EDO A 602 source : AC2 19) chain A residue 350 type sequence A description binding site for residue EDO A 603 source : AC3 20) chain A residue 351 type sequence D description binding site for residue EDO A 603 source : AC3 21) chain A residue 383 type sequence W description binding site for residue EDO A 603 source : AC3 22) chain A residue 323 type sequence E description binding site for residue EDO A 604 source : AC4 23) chain A residue 393 type sequence W description binding site for residue EDO A 604 source : AC4 24) chain A residue 476 type sequence H description binding site for residue DMS A 605 source : AC5 25) chain A residue 479 type sequence L description binding site for residue DMS A 605 source : AC5 26) chain A residue 480 type sequence D description binding site for residue DMS A 605 source : AC5 27) chain A residue 506 type sequence Q description binding site for residue DMS A 605 source : AC5 28) chain A residue 509 type sequence L description binding site for residue DMS A 605 source : AC5 29) chain A residue 537 type MOD_RES sequence S description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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