eF-site ID 6chh-C PDB Code 6chh Chain C click to enlarge Title Structure of human NNMT in complex with bisubstrate inhibitor MS2756 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Nicotinamide N-methyltransferase Source (NNMT_HUMAN) Sequence C:  NPRDYLEKYYKFGHSAESQILKHLLKNLFKIFCLDGVKGD LLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKW LKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQ VLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYC RALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLG REAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVA RKLS Description Functional site 1) chain C residue 20 type sequence Y description binding site for residue F0P C 301 source : AC5 2) chain C residue 24 type sequence Y description binding site for residue F0P C 301 source : AC5 3) chain C residue 25 type sequence Y description binding site for residue F0P C 301 source : AC5 4) chain C residue 63 type sequence G description binding site for residue F0P C 301 source : AC5 5) chain C residue 64 type sequence S description binding site for residue F0P C 301 source : AC5 6) chain C residue 65 type sequence G description binding site for residue F0P C 301 source : AC5 7) chain C residue 67 type sequence T description binding site for residue F0P C 301 source : AC5 8) chain C residue 69 type sequence Y description binding site for residue F0P C 301 source : AC5 9) chain C residue 70 type sequence Q description binding site for residue F0P C 301 source : AC5 10) chain C residue 85 type sequence D description binding site for residue F0P C 301 source : AC5 11) chain C residue 86 type sequence Y description binding site for residue F0P C 301 source : AC5 12) chain C residue 90 type sequence N description binding site for residue F0P C 301 source : AC5 13) chain C residue 141 type sequence C description binding site for residue F0P C 301 source : AC5 14) chain C residue 142 type sequence D description binding site for residue F0P C 301 source : AC5 15) chain C residue 143 type sequence V description binding site for residue F0P C 301 source : AC5 16) chain C residue 163 type sequence T description binding site for residue F0P C 301 source : AC5 17) chain C residue 164 type sequence L description binding site for residue F0P C 301 source : AC5 18) chain C residue 165 type sequence C description binding site for residue F0P C 301 source : AC5 19) chain C residue 167 type sequence D description binding site for residue F0P C 301 source : AC5 20) chain C residue 169 type sequence A description binding site for residue F0P C 301 source : AC5 21) chain C residue 201 type sequence S description binding site for residue F0P C 301 source : AC5 22) chain C residue 204 type sequence Y description binding site for residue F0P C 301 source : AC5 23) chain C residue 213 type sequence S description binding site for residue F0P C 301 source : AC5 24) chain C residue 242 type sequence Y description binding site for residue F0P C 301 source : AC5 25) chain C residue 20 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI1 26) chain C residue 25 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI1 27) chain C residue 63 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI1 28) chain C residue 69 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI1 29) chain C residue 85 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI1 30) chain C residue 90 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI1 31) chain C residue 142 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI1 32) chain C residue 163 type BINDING sequence T description BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI1 33) chain C residue 197 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21823666 source Swiss-Prot : SWS_FT_FI2 34) chain C residue 213 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21823666 source Swiss-Prot : SWS_FT_FI2 35) chain C residue 18 type MOD_RES sequence R description Citrulline; alternate => ECO:0000269|PubMed:30044909 source Swiss-Prot : SWS_FT_FI3 36) chain C residue 132 type MOD_RES sequence R description Citrulline; alternate => ECO:0000269|PubMed:30044909 source Swiss-Prot : SWS_FT_FI3 37) chain C residue 181 type MOD_RES sequence R description Citrulline; alternate => ECO:0000269|PubMed:30044909 source Swiss-Prot : SWS_FT_FI3 38) chain C residue 39 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4

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