eF-site ID 6ce0-BDEGHL PDB Code 6ce0 Chain B, D, E, G, H, L click to enlarge Title Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom Classification viral protein/immune system Compound Envelope glycoprotein gp160 Source (6CE0) Sequence B:  IGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGNPDWLPD MTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTN VPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLE ESQNQQEKNEQDLLALD D:  EGQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQT AGRGPEWMGWISPYSGDKNLAPAFQDRVIMTTDTEVPVTS FTSTGAAYMEIRNLKFDDTGTYFCAKGLLRDGSSTWLPYL WGQGTLLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLV KDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVV TVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGLEV E:  SVLTQSASVSGSLGQSVTISCTGPNSVCCSHKSISWYQWP PGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLR PEDETTYYCCSYTHNSGCVFGTGTKVSVLGQSKANPSVTL FPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKA GVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTH EGSTVEKTVAPTE G:  EKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWAT HACVPTDPNPQEVLLENVTEEFNMWKNSMVEQMHEDIISL WDQSLKPCVKLTPFCVTLNCTNYGDIKQCSFNITTEISKR RNESALFSKLDLEPINNSNTSYRLIKCNTSVIKQACPKVS FEPIPIHYCAPAGFAILKCNDKRFNGTGPCKNVSTVQCTH GIKPVVSTQLLLNGSLAEEEVVIRSENLTNNAKNIIIQLN ESVVITCERPNNNTRKRVTLGPGKVLYTTGEIIGNIRKAH CNISKTNWTRTLERIVIKLREQFKNKTIVFNQSSGGDLEI VMHVFNCGGEFFYCNTTQLFNSTYNSTTDSIITLPCRIKQ IINRWQEVGKAMYAPPIAGQIRCQSNITGLILTRDGGGNG TNGTEVFRPAGGDMKDNWRSELYKYKVVRIEPLGIAPTKC KRRVVG H:  VQLQESGPGLVRPSETLSVTCIVSGGSISNYYWTWIRQSP GKGLEWIGYISDRETTTYNPSLNSRAVISRDTSKNQLSLQ LRSVTTADTAIYFCATARRGQRIYGVVSFGEFFYYYYMDV WGKGTAVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFP EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTQTYICNVNHKPSNTKVDKKVEP L:  SYVSPLSVALGETARISCGRQALGSRAVQWYQHKPGQAPI LLIYNNQDRPSGIPERFSGTPDINFGTTATLTISGVEVGD EADYYCHMWDSRSGFSWSFGGATRLTVLSQPKAAPSVTLF PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG VETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHE GSTVEKTVAPT Description Functional site 1) chain H residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 2) chain L residue 191-197 type prosite sequence YSCQVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 3) chain E residue 195-201 type prosite sequence YSCQVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 4) chain D residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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