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eF-site ID
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6cdm-ABCDEF |
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PDB Code
|
6cdm |
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Chain
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A, B, C, D, E, F |
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click to enlarge
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Title
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Structure of vaccine-elicited HIV-1 neutralizing antibody vFP7.04 in complex with HIV-1 fusion peptide residue 512-519 |
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Classification
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IMMUNE SYSTEM |
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Compound
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vFP7.04 heavy chain |
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Source
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(6CDM) |
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Sequence
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A: |
QVQLQQSGAELVRPGASVTLSCKASGYTFTDYEMHWVKQT
PVHGLEWIGAIVPETGFTAYTQKFKGKAMLTADKSSSTAY
MELRSLTSEDSAVYFCSRLRLYWYFDVWGTGTTVTVSSAS
TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI
CNVNHKPSNTKVDKKVEP
|
| B: |
GVLMTQTPLSLPVRLGDQASISCRSSQSIVYSNGNTYLEW
YLQRPGQSPKLLIYKVSNRFSGVPDRVSGSGSGTDFTLKI
SRVEAEDLGVYYCFQGSHVPYTFGGGTKLEIKRTVAAPSV
FIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACE
VTHQGLSSPVTKSFNRGE
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| C: |
AVGIGA
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| D: |
QVQLQQSGAELVRPGASVTLSCKASGYTFTDYEMHWVKQT
PVHGLEWIGAIVPETGFTAYTQKFKGKAMLTADKSSSTAY
MELRSLTSEDSAVYFCSRLRLYWYFDVWGTGTTVTVSSAS
TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI
CNVNHKPSNTKVDKKVEP
|
| E: |
GVLMTQTPLSLPVRLGDQASISCRSSQSIVYSNGNTYLEW
YLQRPGQSPKLLIYKVSNRFSGVPDRVSGSGSGTDFTLKI
SRVEAEDLGVYYCFQGSHVPYTFGGGTKLEIKRTVAAPSV
FIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACE
VTHQGLSSPVTKSFNRGE
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| F: |
AVGIGA
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Description
|
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Functional site
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|
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1)
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chain |
B |
| residue |
192-198 |
| type |
prosite |
| sequence |
YACEVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
|
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2)
|
chain |
A |
| residue |
194-200 |
| type |
prosite |
| sequence |
YICNVNH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
|
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