eF-site ID 6cbi-D
PDB Code 6cbi
Chain D

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Title PCNA in complex with inhibitor
Classification CELL CYCLE
Compound Proliferating cell nuclear antigen
Source (6CBI)
Sequence D:  MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM
DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK
CAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISC
AKDGVKFSASGELGNGNIKLSQTKEEEAVTIEMNEPVQLT
FALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGH
LKYYLAPKI
Description (1)  Proliferating cell nuclear antigen, GLY-ARG-LYS-ARG-ARG-GLN-DAB-SER-MET-THR-GLU-PHE-TYR-HIS


Functional site

1) chain D
residue 42
type
sequence S
description binding site for residue SO4 D 301
source : AC2

2) chain D
residue 45
type
sequence V
description binding site for Di-peptide GLN J 144 and DAB J 145
source : AC9

3) chain D
residue 252
type
sequence A
description binding site for Di-peptide GLN J 144 and DAB J 145
source : AC9

4) chain D
residue 253
type
sequence P
description binding site for Di-peptide GLN J 144 and DAB J 145
source : AC9

5) chain D
residue 254
type
sequence K
description binding site for Di-peptide GLN J 144 and DAB J 145
source : AC9

6) chain D
residue 252
type
sequence A
description binding site for Di-peptide DAB J 145 and GLU J 149
source : AD1

7) chain D
residue 253
type
sequence P
description binding site for Di-peptide DAB J 145 and GLU J 149
source : AD1

8) chain D
residue 44
type
sequence H
description binding site for Di-peptide DAB J 145 and SER J 146
source : AD2

9) chain D
residue 252
type
sequence A
description binding site for Di-peptide DAB J 145 and SER J 146
source : AD2

10) chain D
residue 253
type
sequence P
description binding site for Di-peptide DAB J 145 and SER J 146
source : AD2

11) chain D
residue 61-80
type MOD_RES
sequence RCDRNLAMGVNLTSMSKILK
description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683
source Swiss-Prot : SWS_FT_FI1

12) chain D
residue 14
type MOD_RES
sequence K
description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316
source Swiss-Prot : SWS_FT_FI2

13) chain D
residue 77
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

14) chain D
residue 80
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

15) chain D
residue 248
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI3

16) chain D
residue 211
type MOD_RES
sequence Y
description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032
source Swiss-Prot : SWS_FT_FI4

17) chain D
residue 164
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289
source Swiss-Prot : SWS_FT_FI5

18) chain D
residue 254
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI6


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