eF-site ID 6c6r-B PDB Code 6c6r Chain B click to enlarge Title Human Squalene Epoxidase (SQLE, Squalene Monooxygenase) structure with FAD Classification OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Compound Squalene monooxygenase Source (ERG1_HUMAN) Sequence B:  NDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDR IVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQE SKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEP NAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLT VVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANH AELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMV EKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKR GVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDL YDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATD DSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIG HFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVI FPLIYSEMKY Description Functional site 1) chain B residue 525 type sequence A description binding site for residue CPS A 602 source : AC2 2) chain B residue 547 type sequence L description binding site for residue CPS A 603 source : AC3 3) chain B residue 456 type sequence W description binding site for residue CPS A 605 source : AC5 4) chain B residue 130 type sequence G description binding site for residue FAD B 601 source : AC7 5) chain B residue 132 type sequence G description binding site for residue FAD B 601 source : AC7 6) chain B residue 133 type sequence V description binding site for residue FAD B 601 source : AC7 7) chain B residue 134 type sequence L description binding site for residue FAD B 601 source : AC7 8) chain B residue 152 type sequence I description binding site for residue FAD B 601 source : AC7 9) chain B residue 153 type sequence E description binding site for residue FAD B 601 source : AC7 10) chain B residue 154 type sequence R description binding site for residue FAD B 601 source : AC7 11) chain B residue 161 type sequence R description binding site for residue FAD B 601 source : AC7 12) chain B residue 163 type sequence V description binding site for residue FAD B 601 source : AC7 13) chain B residue 164 type sequence G description binding site for residue FAD B 601 source : AC7 14) chain B residue 166 type sequence F description binding site for residue FAD B 601 source : AC7 15) chain B residue 234 type sequence R description binding site for residue FAD B 601 source : AC7 16) chain B residue 250 type sequence V description binding site for residue FAD B 601 source : AC7 17) chain B residue 284 type sequence A description binding site for residue FAD B 601 source : AC7 18) chain B residue 285 type sequence D description binding site for residue FAD B 601 source : AC7 19) chain B residue 286 type sequence G description binding site for residue FAD B 601 source : AC7 20) chain B residue 335 type sequence Y description binding site for residue FAD B 601 source : AC7 21) chain B residue 407 type sequence G description binding site for residue FAD B 601 source : AC7 22) chain B residue 408 type sequence D description binding site for residue FAD B 601 source : AC7 23) chain B residue 415 type sequence P description binding site for residue FAD B 601 source : AC7 24) chain B residue 418 type sequence G description binding site for residue FAD B 601 source : AC7 25) chain B residue 420 type sequence G description binding site for residue FAD B 601 source : AC7 26) chain B residue 421 type sequence M description binding site for residue FAD B 601 source : AC7 27) chain B residue 497 type sequence L description binding site for residue CPS B 602 source : AC8 28) chain B residue 528 type sequence I description binding site for residue CPS B 602 source : AC8 29) chain B residue 529 type sequence Y description binding site for residue CPS B 602 source : AC8 30) chain B residue 532 type sequence Y description binding site for residue CPS B 602 source : AC8 31) chain B residue 555 type sequence Y description binding site for residue CPS B 603 source : AC9 32) chain B residue 558 type sequence C description binding site for residue CPS B 603 source : AC9 33) chain B residue 563 type sequence P description binding site for residue CPS B 603 source : AC9 34) chain B residue 566 type sequence Y description binding site for residue CPS B 604 source : AD1 35) chain B residue 469 type sequence L description binding site for residue PEG B 605 source : AD2 36) chain B residue 505 type sequence P description binding site for residue PEG B 605 source : AD2 37) chain B residue 523 type sequence F description binding site for residue PEG B 605 source : AD2 38) chain B residue 153 type BINDING sequence E description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 39) chain B residue 161 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 40) chain B residue 166 type BINDING sequence F description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 41) chain B residue 234 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 42) chain B residue 250 type BINDING sequence V description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 43) chain B residue 408 type BINDING sequence D description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 44) chain B residue 421 type BINDING sequence M description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 45) chain B residue 133 type BINDING sequence V description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 46) chain B residue 195 type SITE sequence Y description Important for enzyme activity => ECO:0000269|PubMed:30626872 source Swiss-Prot : SWS_FT_FI2

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