eF-site ID 6c6r-A
PDB Code 6c6r
Chain A

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Title Human Squalene Epoxidase (SQLE, Squalene Monooxygenase) structure with FAD
Classification OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Compound Squalene monooxygenase
Source (ERG1_HUMAN)
Sequence A:  NDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDR
IVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQE
SKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEP
NAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLT
VVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANH
AELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMV
EKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKR
GVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDL
YDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATD
DSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIG
HFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVI
FPLIYSEMKYM
Description


Functional site

1) chain A
residue 130
type
sequence G
description binding site for residue FAD A 601
source : AC1

2) chain A
residue 132
type
sequence G
description binding site for residue FAD A 601
source : AC1

3) chain A
residue 133
type
sequence V
description binding site for residue FAD A 601
source : AC1

4) chain A
residue 134
type
sequence L
description binding site for residue FAD A 601
source : AC1

5) chain A
residue 152
type
sequence I
description binding site for residue FAD A 601
source : AC1

6) chain A
residue 153
type
sequence E
description binding site for residue FAD A 601
source : AC1

7) chain A
residue 154
type
sequence R
description binding site for residue FAD A 601
source : AC1

8) chain A
residue 161
type
sequence R
description binding site for residue FAD A 601
source : AC1

9) chain A
residue 163
type
sequence V
description binding site for residue FAD A 601
source : AC1

10) chain A
residue 164
type
sequence G
description binding site for residue FAD A 601
source : AC1

11) chain A
residue 166
type
sequence F
description binding site for residue FAD A 601
source : AC1

12) chain A
residue 234
type
sequence R
description binding site for residue FAD A 601
source : AC1

13) chain A
residue 248
type
sequence G
description binding site for residue FAD A 601
source : AC1

14) chain A
residue 249
type
sequence V
description binding site for residue FAD A 601
source : AC1

15) chain A
residue 250
type
sequence V
description binding site for residue FAD A 601
source : AC1

16) chain A
residue 284
type
sequence A
description binding site for residue FAD A 601
source : AC1

17) chain A
residue 285
type
sequence D
description binding site for residue FAD A 601
source : AC1

18) chain A
residue 286
type
sequence G
description binding site for residue FAD A 601
source : AC1

19) chain A
residue 335
type
sequence Y
description binding site for residue FAD A 601
source : AC1

20) chain A
residue 389
type
sequence P
description binding site for residue FAD A 601
source : AC1

21) chain A
residue 407
type
sequence G
description binding site for residue FAD A 601
source : AC1

22) chain A
residue 408
type
sequence D
description binding site for residue FAD A 601
source : AC1

23) chain A
residue 415
type
sequence P
description binding site for residue FAD A 601
source : AC1

24) chain A
residue 418
type
sequence G
description binding site for residue FAD A 601
source : AC1

25) chain A
residue 420
type
sequence G
description binding site for residue FAD A 601
source : AC1

26) chain A
residue 421
type
sequence M
description binding site for residue FAD A 601
source : AC1

27) chain A
residue 497
type
sequence L
description binding site for residue CPS A 602
source : AC2

28) chain A
residue 528
type
sequence I
description binding site for residue CPS A 602
source : AC2

29) chain A
residue 529
type
sequence Y
description binding site for residue CPS A 602
source : AC2

30) chain A
residue 532
type
sequence Y
description binding site for residue CPS A 602
source : AC2

31) chain A
residue 562
type
sequence F
description binding site for residue CPS A 603
source : AC3

32) chain A
residue 566
type
sequence Y
description binding site for residue CPS A 603
source : AC3

33) chain A
residue 555
type
sequence Y
description binding site for residue CPS A 604
source : AC4

34) chain A
residue 559
type
sequence S
description binding site for residue CPS A 604
source : AC4

35) chain A
residue 434
type
sequence L
description binding site for residue CPS A 605
source : AC5

36) chain A
residue 437
type
sequence G
description binding site for residue CPS A 605
source : AC5

37) chain A
residue 449
type
sequence E
description binding site for residue CPS A 605
source : AC5

38) chain A
residue 453
type
sequence S
description binding site for residue CPS A 605
source : AC5

39) chain A
residue 469
type
sequence L
description binding site for residue PEG A 606
source : AC6

40) chain A
residue 505
type
sequence P
description binding site for residue PEG A 606
source : AC6

41) chain A
residue 523
type
sequence F
description binding site for residue PEG A 606
source : AC6

42) chain A
residue 551
type
sequence G
description binding site for residue CPS B 603
source : AC9

43) chain A
residue 133
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

44) chain A
residue 153
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

45) chain A
residue 161
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

46) chain A
residue 166
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

47) chain A
residue 234
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

48) chain A
residue 250
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

49) chain A
residue 408
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

50) chain A
residue 421
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

51) chain A
residue 195
type SITE
sequence Y
description Important for enzyme activity => ECO:0000269|PubMed:30626872
source Swiss-Prot : SWS_FT_FI2


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