eF-site ID 6c6r-A PDB Code 6c6r Chain A click to enlarge Title Human Squalene Epoxidase (SQLE, Squalene Monooxygenase) structure with FAD Classification OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Compound Squalene monooxygenase Source (ERG1_HUMAN) Sequence A:  NDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDR IVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQE SKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEP NAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLT VVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANH AELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMV EKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKR GVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDL YDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATD DSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIG HFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVI FPLIYSEMKYM Description Functional site 1) chain A residue 130 type sequence G description binding site for residue FAD A 601 source : AC1 2) chain A residue 132 type sequence G description binding site for residue FAD A 601 source : AC1 3) chain A residue 133 type sequence V description binding site for residue FAD A 601 source : AC1 4) chain A residue 134 type sequence L description binding site for residue FAD A 601 source : AC1 5) chain A residue 152 type sequence I description binding site for residue FAD A 601 source : AC1 6) chain A residue 153 type sequence E description binding site for residue FAD A 601 source : AC1 7) chain A residue 154 type sequence R description binding site for residue FAD A 601 source : AC1 8) chain A residue 161 type sequence R description binding site for residue FAD A 601 source : AC1 9) chain A residue 163 type sequence V description binding site for residue FAD A 601 source : AC1 10) chain A residue 164 type sequence G description binding site for residue FAD A 601 source : AC1 11) chain A residue 166 type sequence F description binding site for residue FAD A 601 source : AC1 12) chain A residue 234 type sequence R description binding site for residue FAD A 601 source : AC1 13) chain A residue 248 type sequence G description binding site for residue FAD A 601 source : AC1 14) chain A residue 249 type sequence V description binding site for residue FAD A 601 source : AC1 15) chain A residue 250 type sequence V description binding site for residue FAD A 601 source : AC1 16) chain A residue 284 type sequence A description binding site for residue FAD A 601 source : AC1 17) chain A residue 285 type sequence D description binding site for residue FAD A 601 source : AC1 18) chain A residue 286 type sequence G description binding site for residue FAD A 601 source : AC1 19) chain A residue 335 type sequence Y description binding site for residue FAD A 601 source : AC1 20) chain A residue 389 type sequence P description binding site for residue FAD A 601 source : AC1 21) chain A residue 407 type sequence G description binding site for residue FAD A 601 source : AC1 22) chain A residue 408 type sequence D description binding site for residue FAD A 601 source : AC1 23) chain A residue 415 type sequence P description binding site for residue FAD A 601 source : AC1 24) chain A residue 418 type sequence G description binding site for residue FAD A 601 source : AC1 25) chain A residue 420 type sequence G description binding site for residue FAD A 601 source : AC1 26) chain A residue 421 type sequence M description binding site for residue FAD A 601 source : AC1 27) chain A residue 497 type sequence L description binding site for residue CPS A 602 source : AC2 28) chain A residue 528 type sequence I description binding site for residue CPS A 602 source : AC2 29) chain A residue 529 type sequence Y description binding site for residue CPS A 602 source : AC2 30) chain A residue 532 type sequence Y description binding site for residue CPS A 602 source : AC2 31) chain A residue 562 type sequence F description binding site for residue CPS A 603 source : AC3 32) chain A residue 566 type sequence Y description binding site for residue CPS A 603 source : AC3 33) chain A residue 555 type sequence Y description binding site for residue CPS A 604 source : AC4 34) chain A residue 559 type sequence S description binding site for residue CPS A 604 source : AC4 35) chain A residue 434 type sequence L description binding site for residue CPS A 605 source : AC5 36) chain A residue 437 type sequence G description binding site for residue CPS A 605 source : AC5 37) chain A residue 449 type sequence E description binding site for residue CPS A 605 source : AC5 38) chain A residue 453 type sequence S description binding site for residue CPS A 605 source : AC5 39) chain A residue 469 type sequence L description binding site for residue PEG A 606 source : AC6 40) chain A residue 505 type sequence P description binding site for residue PEG A 606 source : AC6 41) chain A residue 523 type sequence F description binding site for residue PEG A 606 source : AC6 42) chain A residue 551 type sequence G description binding site for residue CPS B 603 source : AC9 43) chain A residue 133 type BINDING sequence V description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 44) chain A residue 153 type BINDING sequence E description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 45) chain A residue 161 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 46) chain A residue 166 type BINDING sequence F description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 47) chain A residue 234 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 48) chain A residue 250 type BINDING sequence V description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 49) chain A residue 408 type BINDING sequence D description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 50) chain A residue 421 type BINDING sequence M description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 51) chain A residue 195 type SITE sequence Y description Important for enzyme activity => ECO:0000269|PubMed:30626872 source Swiss-Prot : SWS_FT_FI2

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