eF-site ID 6c6n-B PDB Code 6c6n Chain B click to enlarge Title Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and Cmpd-4" Classification FLAVOPROTEIN/INHIBITOR Compound Squalene monooxygenase Source (ERG1_HUMAN) Sequence B:  NDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDR IVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQE SKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEP NAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLT VVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANH AELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMV EKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKR GVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDL YDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATD DSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIG HFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVI FPLIYSEMKY Description Functional site 1) chain B residue 497 type sequence L description binding site for residue CPS A 605 source : AC5 2) chain B residue 529 type sequence Y description binding site for residue CPS A 605 source : AC5 3) chain B residue 532 type sequence Y description binding site for residue CPS A 605 source : AC5 4) chain B residue 515 type sequence N description binding site for residue CPS A 606 source : AC6 5) chain B residue 525 type sequence A description binding site for residue CPS A 606 source : AC6 6) chain B residue 551 type sequence G description binding site for residue CPS A 608 source : AC8 7) chain B residue 456 type sequence W description binding site for residue CPS A 609 source : AC9 8) chain B residue 213 type sequence S description binding site for residue GOL B 601 source : AD3 9) chain B residue 215 type sequence N description binding site for residue GOL B 601 source : AD3 10) chain B residue 219 type sequence Q description binding site for residue GOL B 601 source : AD3 11) chain B residue 310 type sequence L description binding site for residue SO4 B 602 source : AD4 12) chain B residue 343 type sequence R description binding site for residue SO4 B 602 source : AD4 13) chain B residue 386 type sequence R description binding site for residue SO4 B 602 source : AD4 14) chain B residue 555 type sequence Y description binding site for residue CPS B 603 source : AD5 15) chain B residue 559 type sequence S description binding site for residue CPS B 603 source : AD5 16) chain B residue 562 type sequence F description binding site for residue CPS B 604 source : AD6 17) chain B residue 566 type sequence Y description binding site for residue CPS B 604 source : AD6 18) chain B residue 166 type sequence F description binding site for residue EKV B 605 source : AD7 19) chain B residue 195 type sequence Y description binding site for residue EKV B 605 source : AD7 20) chain B residue 210 type sequence Y description binding site for residue EKV B 605 source : AD7 21) chain B residue 322 type sequence A description binding site for residue EKV B 605 source : AD7 22) chain B residue 333 type sequence L description binding site for residue EKV B 605 source : AD7 23) chain B residue 335 type sequence Y description binding site for residue EKV B 605 source : AD7 24) chain B residue 415 type sequence P description binding site for residue EKV B 605 source : AD7 25) chain B residue 416 type sequence L description binding site for residue EKV B 605 source : AD7 26) chain B residue 418 type sequence G description binding site for residue EKV B 605 source : AD7 27) chain B residue 473 type sequence L description binding site for residue EKV B 605 source : AD7 28) chain B residue 477 type sequence F description binding site for residue EKV B 605 source : AD7 29) chain B residue 495 type sequence F description binding site for residue EKV B 605 source : AD7 30) chain B residue 505 type sequence P description binding site for residue EKV B 605 source : AD7 31) chain B residue 506 type sequence V description binding site for residue EKV B 605 source : AD7 32) chain B residue 509 type sequence L description binding site for residue EKV B 605 source : AD7 33) chain B residue 519 type sequence L description binding site for residue EKV B 605 source : AD7 34) chain B residue 522 type sequence H description binding site for residue EKV B 605 source : AD7 35) chain B residue 523 type sequence F description binding site for residue EKV B 605 source : AD7 36) chain B residue 526 type sequence V description binding site for residue EKV B 605 source : AD7 37) chain B residue 130 type sequence G description binding site for residue FAD B 606 source : AD8 38) chain B residue 132 type sequence G description binding site for residue FAD B 606 source : AD8 39) chain B residue 133 type sequence V description binding site for residue FAD B 606 source : AD8 40) chain B residue 134 type sequence L description binding site for residue FAD B 606 source : AD8 41) chain B residue 152 type sequence I description binding site for residue FAD B 606 source : AD8 42) chain B residue 153 type sequence E description binding site for residue FAD B 606 source : AD8 43) chain B residue 154 type sequence R description binding site for residue FAD B 606 source : AD8 44) chain B residue 161 type sequence R description binding site for residue FAD B 606 source : AD8 45) chain B residue 163 type sequence V description binding site for residue FAD B 606 source : AD8 46) chain B residue 164 type sequence G description binding site for residue FAD B 606 source : AD8 47) chain B residue 165 type sequence E description binding site for residue FAD B 606 source : AD8 48) chain B residue 166 type sequence F description binding site for residue FAD B 606 source : AD8 49) chain B residue 234 type sequence R description binding site for residue FAD B 606 source : AD8 50) chain B residue 250 type sequence V description binding site for residue FAD B 606 source : AD8 51) chain B residue 285 type sequence D description binding site for residue FAD B 606 source : AD8 52) chain B residue 286 type sequence G description binding site for residue FAD B 606 source : AD8 53) chain B residue 389 type sequence P description binding site for residue FAD B 606 source : AD8 54) chain B residue 407 type sequence G description binding site for residue FAD B 606 source : AD8 55) chain B residue 408 type sequence D description binding site for residue FAD B 606 source : AD8 56) chain B residue 415 type sequence P description binding site for residue FAD B 606 source : AD8 57) chain B residue 418 type sequence G description binding site for residue FAD B 606 source : AD8 58) chain B residue 420 type sequence G description binding site for residue FAD B 606 source : AD8 59) chain B residue 421 type sequence M description binding site for residue FAD B 606 source : AD8 60) chain B residue 153 type BINDING sequence E description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 61) chain B residue 161 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 62) chain B residue 166 type BINDING sequence F description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 63) chain B residue 234 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 64) chain B residue 250 type BINDING sequence V description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 65) chain B residue 408 type BINDING sequence D description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 66) chain B residue 421 type BINDING sequence M description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 67) chain B residue 133 type BINDING sequence V description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 68) chain B residue 195 type SITE sequence Y description Important for enzyme activity => ECO:0000269|PubMed:30626872 source Swiss-Prot : SWS_FT_FI2

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