eF-site ID 6c6n-A
PDB Code 6c6n
Chain A

click to enlarge
Title Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and Cmpd-4"
Classification FLAVOPROTEIN/INHIBITOR
Compound Squalene monooxygenase
Source (ERG1_HUMAN)
Sequence A:  NDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDR
IVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQE
SKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEP
NAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLT
VVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANH
AELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMV
EKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKR
GVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDL
YDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATD
DSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIG
HFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVI
FPLIYSEMKY
Description


Functional site

1) chain A
residue 173
type
sequence H
description binding site for residue GOL A 601
source : AC1

2) chain A
residue 219
type
sequence Q
description binding site for residue GOL A 601
source : AC1

3) chain A
residue 185
type
sequence E
description binding site for residue GOL A 602
source : AC2

4) chain A
residue 186
type
sequence G
description binding site for residue GOL A 602
source : AC2

5) chain A
residue 187
type
sequence L
description binding site for residue GOL A 602
source : AC2

6) chain A
residue 188
type
sequence D
description binding site for residue GOL A 602
source : AC2

7) chain A
residue 173
type
sequence H
description binding site for residue GOL A 603
source : AC3

8) chain A
residue 177
type
sequence D
description binding site for residue GOL A 603
source : AC3

9) chain A
residue 426
type
sequence K
description binding site for residue GOL A 603
source : AC3

10) chain A
residue 429
type
sequence K
description binding site for residue GOL A 603
source : AC3

11) chain A
residue 310
type
sequence L
description binding site for residue SO4 A 604
source : AC4

12) chain A
residue 343
type
sequence R
description binding site for residue SO4 A 604
source : AC4

13) chain A
residue 386
type
sequence R
description binding site for residue SO4 A 604
source : AC4

14) chain A
residue 515
type
sequence N
description binding site for residue CPS A 605
source : AC5

15) chain A
residue 525
type
sequence A
description binding site for residue CPS A 605
source : AC5

16) chain A
residue 529
type
sequence Y
description binding site for residue CPS A 606
source : AC6

17) chain A
residue 532
type
sequence Y
description binding site for residue CPS A 606
source : AC6

18) chain A
residue 562
type
sequence F
description binding site for residue CPS A 607
source : AC7

19) chain A
residue 566
type
sequence Y
description binding site for residue CPS A 607
source : AC7

20) chain A
residue 555
type
sequence Y
description binding site for residue CPS A 608
source : AC8

21) chain A
residue 559
type
sequence S
description binding site for residue CPS A 608
source : AC8

22) chain A
residue 562
type
sequence F
description binding site for residue CPS A 608
source : AC8

23) chain A
residue 563
type
sequence P
description binding site for residue CPS A 608
source : AC8

24) chain A
residue 434
type
sequence L
description binding site for residue CPS A 609
source : AC9

25) chain A
residue 437
type
sequence G
description binding site for residue CPS A 609
source : AC9

26) chain A
residue 449
type
sequence E
description binding site for residue CPS A 609
source : AC9

27) chain A
residue 453
type
sequence S
description binding site for residue CPS A 609
source : AC9

28) chain A
residue 166
type
sequence F
description binding site for residue EKV A 610
source : AD1

29) chain A
residue 195
type
sequence Y
description binding site for residue EKV A 610
source : AD1

30) chain A
residue 210
type
sequence Y
description binding site for residue EKV A 610
source : AD1

31) chain A
residue 333
type
sequence L
description binding site for residue EKV A 610
source : AD1

32) chain A
residue 335
type
sequence Y
description binding site for residue EKV A 610
source : AD1

33) chain A
residue 415
type
sequence P
description binding site for residue EKV A 610
source : AD1

34) chain A
residue 416
type
sequence L
description binding site for residue EKV A 610
source : AD1

35) chain A
residue 418
type
sequence G
description binding site for residue EKV A 610
source : AD1

36) chain A
residue 469
type
sequence L
description binding site for residue EKV A 610
source : AD1

37) chain A
residue 473
type
sequence L
description binding site for residue EKV A 610
source : AD1

38) chain A
residue 477
type
sequence F
description binding site for residue EKV A 610
source : AD1

39) chain A
residue 495
type
sequence F
description binding site for residue EKV A 610
source : AD1

40) chain A
residue 505
type
sequence P
description binding site for residue EKV A 610
source : AD1

41) chain A
residue 509
type
sequence L
description binding site for residue EKV A 610
source : AD1

42) chain A
residue 522
type
sequence H
description binding site for residue EKV A 610
source : AD1

43) chain A
residue 523
type
sequence F
description binding site for residue EKV A 610
source : AD1

44) chain A
residue 526
type
sequence V
description binding site for residue EKV A 610
source : AD1

45) chain A
residue 130
type
sequence G
description binding site for residue FAD A 611
source : AD2

46) chain A
residue 132
type
sequence G
description binding site for residue FAD A 611
source : AD2

47) chain A
residue 133
type
sequence V
description binding site for residue FAD A 611
source : AD2

48) chain A
residue 134
type
sequence L
description binding site for residue FAD A 611
source : AD2

49) chain A
residue 152
type
sequence I
description binding site for residue FAD A 611
source : AD2

50) chain A
residue 153
type
sequence E
description binding site for residue FAD A 611
source : AD2

51) chain A
residue 154
type
sequence R
description binding site for residue FAD A 611
source : AD2

52) chain A
residue 161
type
sequence R
description binding site for residue FAD A 611
source : AD2

53) chain A
residue 163
type
sequence V
description binding site for residue FAD A 611
source : AD2

54) chain A
residue 164
type
sequence G
description binding site for residue FAD A 611
source : AD2

55) chain A
residue 165
type
sequence E
description binding site for residue FAD A 611
source : AD2

56) chain A
residue 166
type
sequence F
description binding site for residue FAD A 611
source : AD2

57) chain A
residue 234
type
sequence R
description binding site for residue FAD A 611
source : AD2

58) chain A
residue 249
type
sequence V
description binding site for residue FAD A 611
source : AD2

59) chain A
residue 250
type
sequence V
description binding site for residue FAD A 611
source : AD2

60) chain A
residue 284
type
sequence A
description binding site for residue FAD A 611
source : AD2

61) chain A
residue 285
type
sequence D
description binding site for residue FAD A 611
source : AD2

62) chain A
residue 286
type
sequence G
description binding site for residue FAD A 611
source : AD2

63) chain A
residue 389
type
sequence P
description binding site for residue FAD A 611
source : AD2

64) chain A
residue 407
type
sequence G
description binding site for residue FAD A 611
source : AD2

65) chain A
residue 408
type
sequence D
description binding site for residue FAD A 611
source : AD2

66) chain A
residue 415
type
sequence P
description binding site for residue FAD A 611
source : AD2

67) chain A
residue 418
type
sequence G
description binding site for residue FAD A 611
source : AD2

68) chain A
residue 420
type
sequence G
description binding site for residue FAD A 611
source : AD2

69) chain A
residue 421
type
sequence M
description binding site for residue FAD A 611
source : AD2

70) chain A
residue 551
type
sequence G
description binding site for residue CPS B 603
source : AD5

71) chain A
residue 544
type
sequence P
description binding site for residue CPS B 604
source : AD6

72) chain A
residue 547
type
sequence L
description binding site for residue CPS B 604
source : AD6

73) chain A
residue 133
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

74) chain A
residue 153
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

75) chain A
residue 161
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

76) chain A
residue 166
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

77) chain A
residue 234
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

78) chain A
residue 250
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

79) chain A
residue 408
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

80) chain A
residue 421
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N
source Swiss-Prot : SWS_FT_FI1

81) chain A
residue 195
type SITE
sequence Y
description Important for enzyme activity => ECO:0000269|PubMed:30626872
source Swiss-Prot : SWS_FT_FI2


Display surface

Download
Links