eF-site ID 6c6n-A PDB Code 6c6n Chain A click to enlarge Title Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and Cmpd-4" Classification FLAVOPROTEIN/INHIBITOR Compound Squalene monooxygenase Source (ERG1_HUMAN) Sequence A:  NDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDR IVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQE SKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEP NAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLT VVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANH AELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMV EKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKR GVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDL YDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATD DSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIG HFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVI FPLIYSEMKY Description Functional site 1) chain A residue 173 type sequence H description binding site for residue GOL A 601 source : AC1 2) chain A residue 219 type sequence Q description binding site for residue GOL A 601 source : AC1 3) chain A residue 185 type sequence E description binding site for residue GOL A 602 source : AC2 4) chain A residue 186 type sequence G description binding site for residue GOL A 602 source : AC2 5) chain A residue 187 type sequence L description binding site for residue GOL A 602 source : AC2 6) chain A residue 188 type sequence D description binding site for residue GOL A 602 source : AC2 7) chain A residue 173 type sequence H description binding site for residue GOL A 603 source : AC3 8) chain A residue 177 type sequence D description binding site for residue GOL A 603 source : AC3 9) chain A residue 426 type sequence K description binding site for residue GOL A 603 source : AC3 10) chain A residue 429 type sequence K description binding site for residue GOL A 603 source : AC3 11) chain A residue 310 type sequence L description binding site for residue SO4 A 604 source : AC4 12) chain A residue 343 type sequence R description binding site for residue SO4 A 604 source : AC4 13) chain A residue 386 type sequence R description binding site for residue SO4 A 604 source : AC4 14) chain A residue 515 type sequence N description binding site for residue CPS A 605 source : AC5 15) chain A residue 525 type sequence A description binding site for residue CPS A 605 source : AC5 16) chain A residue 529 type sequence Y description binding site for residue CPS A 606 source : AC6 17) chain A residue 532 type sequence Y description binding site for residue CPS A 606 source : AC6 18) chain A residue 562 type sequence F description binding site for residue CPS A 607 source : AC7 19) chain A residue 566 type sequence Y description binding site for residue CPS A 607 source : AC7 20) chain A residue 555 type sequence Y description binding site for residue CPS A 608 source : AC8 21) chain A residue 559 type sequence S description binding site for residue CPS A 608 source : AC8 22) chain A residue 562 type sequence F description binding site for residue CPS A 608 source : AC8 23) chain A residue 563 type sequence P description binding site for residue CPS A 608 source : AC8 24) chain A residue 434 type sequence L description binding site for residue CPS A 609 source : AC9 25) chain A residue 437 type sequence G description binding site for residue CPS A 609 source : AC9 26) chain A residue 449 type sequence E description binding site for residue CPS A 609 source : AC9 27) chain A residue 453 type sequence S description binding site for residue CPS A 609 source : AC9 28) chain A residue 166 type sequence F description binding site for residue EKV A 610 source : AD1 29) chain A residue 195 type sequence Y description binding site for residue EKV A 610 source : AD1 30) chain A residue 210 type sequence Y description binding site for residue EKV A 610 source : AD1 31) chain A residue 333 type sequence L description binding site for residue EKV A 610 source : AD1 32) chain A residue 335 type sequence Y description binding site for residue EKV A 610 source : AD1 33) chain A residue 415 type sequence P description binding site for residue EKV A 610 source : AD1 34) chain A residue 416 type sequence L description binding site for residue EKV A 610 source : AD1 35) chain A residue 418 type sequence G description binding site for residue EKV A 610 source : AD1 36) chain A residue 469 type sequence L description binding site for residue EKV A 610 source : AD1 37) chain A residue 473 type sequence L description binding site for residue EKV A 610 source : AD1 38) chain A residue 477 type sequence F description binding site for residue EKV A 610 source : AD1 39) chain A residue 495 type sequence F description binding site for residue EKV A 610 source : AD1 40) chain A residue 505 type sequence P description binding site for residue EKV A 610 source : AD1 41) chain A residue 509 type sequence L description binding site for residue EKV A 610 source : AD1 42) chain A residue 522 type sequence H description binding site for residue EKV A 610 source : AD1 43) chain A residue 523 type sequence F description binding site for residue EKV A 610 source : AD1 44) chain A residue 526 type sequence V description binding site for residue EKV A 610 source : AD1 45) chain A residue 130 type sequence G description binding site for residue FAD A 611 source : AD2 46) chain A residue 132 type sequence G description binding site for residue FAD A 611 source : AD2 47) chain A residue 133 type sequence V description binding site for residue FAD A 611 source : AD2 48) chain A residue 134 type sequence L description binding site for residue FAD A 611 source : AD2 49) chain A residue 152 type sequence I description binding site for residue FAD A 611 source : AD2 50) chain A residue 153 type sequence E description binding site for residue FAD A 611 source : AD2 51) chain A residue 154 type sequence R description binding site for residue FAD A 611 source : AD2 52) chain A residue 161 type sequence R description binding site for residue FAD A 611 source : AD2 53) chain A residue 163 type sequence V description binding site for residue FAD A 611 source : AD2 54) chain A residue 164 type sequence G description binding site for residue FAD A 611 source : AD2 55) chain A residue 165 type sequence E description binding site for residue FAD A 611 source : AD2 56) chain A residue 166 type sequence F description binding site for residue FAD A 611 source : AD2 57) chain A residue 234 type sequence R description binding site for residue FAD A 611 source : AD2 58) chain A residue 249 type sequence V description binding site for residue FAD A 611 source : AD2 59) chain A residue 250 type sequence V description binding site for residue FAD A 611 source : AD2 60) chain A residue 284 type sequence A description binding site for residue FAD A 611 source : AD2 61) chain A residue 285 type sequence D description binding site for residue FAD A 611 source : AD2 62) chain A residue 286 type sequence G description binding site for residue FAD A 611 source : AD2 63) chain A residue 389 type sequence P description binding site for residue FAD A 611 source : AD2 64) chain A residue 407 type sequence G description binding site for residue FAD A 611 source : AD2 65) chain A residue 408 type sequence D description binding site for residue FAD A 611 source : AD2 66) chain A residue 415 type sequence P description binding site for residue FAD A 611 source : AD2 67) chain A residue 418 type sequence G description binding site for residue FAD A 611 source : AD2 68) chain A residue 420 type sequence G description binding site for residue FAD A 611 source : AD2 69) chain A residue 421 type sequence M description binding site for residue FAD A 611 source : AD2 70) chain A residue 551 type sequence G description binding site for residue CPS B 603 source : AD5 71) chain A residue 544 type sequence P description binding site for residue CPS B 604 source : AD6 72) chain A residue 547 type sequence L description binding site for residue CPS B 604 source : AD6 73) chain A residue 133 type BINDING sequence V description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 74) chain A residue 153 type BINDING sequence E description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 75) chain A residue 161 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 76) chain A residue 166 type BINDING sequence F description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 77) chain A residue 234 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 78) chain A residue 250 type BINDING sequence V description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 79) chain A residue 408 type BINDING sequence D description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 80) chain A residue 421 type BINDING sequence M description BINDING => ECO:0000269|PubMed:30626872, ECO:0007744|PDB:6C6N source Swiss-Prot : SWS_FT_FI1 81) chain A residue 195 type SITE sequence Y description Important for enzyme activity => ECO:0000269|PubMed:30626872 source Swiss-Prot : SWS_FT_FI2

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