eF-site ID 6c5a-F PDB Code 6c5a Chain F click to enlarge Title Human UDP-Glucose Dehydrogenase with UDP- Glc and NADH bound Classification OXIDOREDUCTASE Compound UDP-glucose 6-dehydrogenase Source (UGDH_HUMAN) Sequence F:  FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESR INAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKE ADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSN GYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPE FLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEH WVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALC EATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDV LNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDS LFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEG AHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACDG AHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDG LHNELQTIGFQIETIGKKV Description Functional site 1) chain F residue 260 type sequence R description binding site for residue UPG E 501 source : AD4 2) chain F residue 10 type sequence I description binding site for residue NAI F 501 source : AD5 3) chain F residue 11 type sequence G description binding site for residue NAI F 501 source : AD5 4) chain F residue 13 type sequence G description binding site for residue NAI F 501 source : AD5 5) chain F residue 14 type sequence Y description binding site for residue NAI F 501 source : AD5 6) chain F residue 15 type sequence V description binding site for residue NAI F 501 source : AD5 7) chain F residue 36 type sequence D description binding site for residue NAI F 501 source : AD5 8) chain F residue 37 type sequence V description binding site for residue NAI F 501 source : AD5 9) chain F residue 41 type sequence R description binding site for residue NAI F 501 source : AD5 10) chain F residue 75 type sequence I description binding site for residue NAI F 501 source : AD5 11) chain F residue 88 type sequence S description binding site for residue NAI F 501 source : AD5 12) chain F residue 89 type sequence V description binding site for residue NAI F 501 source : AD5 13) chain F residue 90 type sequence N description binding site for residue NAI F 501 source : AD5 14) chain F residue 91 type sequence T description binding site for residue NAI F 501 source : AD5 15) chain F residue 108 type sequence Y description binding site for residue NAI F 501 source : AD5 16) chain F residue 130 type sequence S description binding site for residue NAI F 501 source : AD5 17) chain F residue 131 type sequence T description binding site for residue NAI F 501 source : AD5 18) chain F residue 161 type sequence E description binding site for residue NAI F 501 source : AD5 19) chain F residue 163 type sequence L description binding site for residue NAI F 501 source : AD5 20) chain F residue 165 type sequence E description binding site for residue NAI F 501 source : AD5 21) chain F residue 276 type sequence C description binding site for residue NAI F 501 source : AD5 22) chain F residue 279 type sequence K description binding site for residue NAI F 501 source : AD5 23) chain F residue 346 type sequence R description binding site for residue NAI F 501 source : AD5 24) chain F residue 161 type sequence E description binding site for residue UPG F 502 source : AD6 25) chain F residue 162 type sequence F description binding site for residue UPG F 502 source : AD6 26) chain F residue 163 type sequence L description binding site for residue UPG F 502 source : AD6 27) chain F residue 164 type sequence A description binding site for residue UPG F 502 source : AD6 28) chain F residue 165 type sequence E description binding site for residue UPG F 502 source : AD6 29) chain F residue 220 type sequence K description binding site for residue UPG F 502 source : AD6 30) chain F residue 224 type sequence N description binding site for residue UPG F 502 source : AD6 31) chain F residue 231 type sequence I description binding site for residue UPG F 502 source : AD6 32) chain F residue 265 type sequence F description binding site for residue UPG F 502 source : AD6 33) chain F residue 266 type sequence L description binding site for residue UPG F 502 source : AD6 34) chain F residue 267 type sequence K description binding site for residue UPG F 502 source : AD6 35) chain F residue 269 type sequence S description binding site for residue UPG F 502 source : AD6 36) chain F residue 272 type sequence F description binding site for residue UPG F 502 source : AD6 37) chain F residue 273 type sequence G description binding site for residue UPG F 502 source : AD6 38) chain F residue 276 type sequence C description binding site for residue UPG F 502 source : AD6 39) chain F residue 277 type sequence F description binding site for residue UPG F 502 source : AD6 40) chain F residue 338 type sequence F description binding site for residue UPG F 502 source : AD6 41) chain F residue 339 type sequence K description binding site for residue UPG F 502 source : AD6 42) chain F residue 442 type sequence R description binding site for residue UPG F 502 source : AD6 43) chain F residue 162 type sequence F description binding site for residue DMS F 503 source : AD7 44) chain F residue 171 type sequence D description binding site for residue DMS F 503 source : AD7 45) chain F residue 176 type sequence D description binding site for residue DMS F 503 source : AD7 46) chain F residue 276 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI2 47) chain F residue 161 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 48) chain F residue 220 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 49) chain F residue 11 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 50) chain F residue 36 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 51) chain F residue 41 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 52) chain F residue 89 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 53) chain F residue 276 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 54) chain F residue 130 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 source Swiss-Prot : SWS_FT_FI4 55) chain F residue 161 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 56) chain F residue 220 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 57) chain F residue 267 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 58) chain F residue 338 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 59) chain F residue 165 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 source Swiss-Prot : SWS_FT_FI6 60) chain F residue 260 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH source Swiss-Prot : SWS_FT_FI7 61) chain F residue 346 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI8 62) chain F residue 442 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI9 63) chain F residue 107 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI10

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