eF-site ID 6c5a-E PDB Code 6c5a Chain E click to enlarge Title Human UDP-Glucose Dehydrogenase with UDP- Glc and NADH bound Classification OXIDOREDUCTASE Compound UDP-glucose 6-dehydrogenase Source (UGDH_HUMAN) Sequence E:  FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESR INAWNSPTLPYEPGLKEVVESCRGKNLFFSTNIDDAIKEA DLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNG YKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEF LAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHW VPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCE ATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVL NLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSL FNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGA HLHIYDPKVPREQIVVDLSHDQVSRLVTISDPYEACDGAH AVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLH NELQTIGFQIETIGKK Description Functional site 1) chain E residue 10 type sequence I description binding site for residue NAI E 500 source : AD3 2) chain E residue 11 type sequence G description binding site for residue NAI E 500 source : AD3 3) chain E residue 13 type sequence G description binding site for residue NAI E 500 source : AD3 4) chain E residue 14 type sequence Y description binding site for residue NAI E 500 source : AD3 5) chain E residue 15 type sequence V description binding site for residue NAI E 500 source : AD3 6) chain E residue 36 type sequence D description binding site for residue NAI E 500 source : AD3 7) chain E residue 37 type sequence V description binding site for residue NAI E 500 source : AD3 8) chain E residue 41 type sequence R description binding site for residue NAI E 500 source : AD3 9) chain E residue 89 type sequence V description binding site for residue NAI E 500 source : AD3 10) chain E residue 90 type sequence N description binding site for residue NAI E 500 source : AD3 11) chain E residue 91 type sequence T description binding site for residue NAI E 500 source : AD3 12) chain E residue 108 type sequence Y description binding site for residue NAI E 500 source : AD3 13) chain E residue 130 type sequence S description binding site for residue NAI E 500 source : AD3 14) chain E residue 131 type sequence T description binding site for residue NAI E 500 source : AD3 15) chain E residue 161 type sequence E description binding site for residue NAI E 500 source : AD3 16) chain E residue 165 type sequence E description binding site for residue NAI E 500 source : AD3 17) chain E residue 276 type sequence C description binding site for residue NAI E 500 source : AD3 18) chain E residue 279 type sequence K description binding site for residue NAI E 500 source : AD3 19) chain E residue 162 type sequence F description binding site for residue UPG E 501 source : AD4 20) chain E residue 163 type sequence L description binding site for residue UPG E 501 source : AD4 21) chain E residue 165 type sequence E description binding site for residue UPG E 501 source : AD4 22) chain E residue 220 type sequence K description binding site for residue UPG E 501 source : AD4 23) chain E residue 224 type sequence N description binding site for residue UPG E 501 source : AD4 24) chain E residue 231 type sequence I description binding site for residue UPG E 501 source : AD4 25) chain E residue 265 type sequence F description binding site for residue UPG E 501 source : AD4 26) chain E residue 266 type sequence L description binding site for residue UPG E 501 source : AD4 27) chain E residue 267 type sequence K description binding site for residue UPG E 501 source : AD4 28) chain E residue 269 type sequence S description binding site for residue UPG E 501 source : AD4 29) chain E residue 272 type sequence F description binding site for residue UPG E 501 source : AD4 30) chain E residue 273 type sequence G description binding site for residue UPG E 501 source : AD4 31) chain E residue 276 type sequence C description binding site for residue UPG E 501 source : AD4 32) chain E residue 277 type sequence F description binding site for residue UPG E 501 source : AD4 33) chain E residue 338 type sequence F description binding site for residue UPG E 501 source : AD4 34) chain E residue 339 type sequence K description binding site for residue UPG E 501 source : AD4 35) chain E residue 442 type sequence R description binding site for residue UPG E 501 source : AD4 36) chain E residue 260 type sequence R description binding site for residue UPG F 502 source : AD6 37) chain E residue 258 type sequence D description binding site for residue DMS F 503 source : AD7 38) chain E residue 260 type sequence R description binding site for residue DMS F 503 source : AD7 39) chain E residue 276 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI2 40) chain E residue 220 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 41) chain E residue 161 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 42) chain E residue 11 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 43) chain E residue 36 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 44) chain E residue 41 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 45) chain E residue 89 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 46) chain E residue 276 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 47) chain E residue 130 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 source Swiss-Prot : SWS_FT_FI4 48) chain E residue 161 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 49) chain E residue 220 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 50) chain E residue 267 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 51) chain E residue 338 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 52) chain E residue 165 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 source Swiss-Prot : SWS_FT_FI6 53) chain E residue 260 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH source Swiss-Prot : SWS_FT_FI7 54) chain E residue 346 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI8 55) chain E residue 442 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI9 56) chain E residue 107 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI10

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