eF-site ID 6c5a-C
PDB Code 6c5a
Chain C

click to enlarge
Title Human UDP-Glucose Dehydrogenase with UDP- Glc and NADH bound
Classification OXIDOREDUCTASE
Compound UDP-glucose 6-dehydrogenase
Source (UGDH_HUMAN)
Sequence C:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES
RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK
EADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNS
NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP
EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE
HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL
CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD
VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID
SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE
GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD
GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD
GLHNELQTIGFQIETIGKK
Description


Functional site
1) chain C
residue 10
type
sequence I
description binding site for residue NAI C 501
source : AC7
2) chain C
residue 11
type
sequence G
description binding site for residue NAI C 501
source : AC7
3) chain C
residue 13
type
sequence G
description binding site for residue NAI C 501
source : AC7
4) chain C
residue 14
type
sequence Y
description binding site for residue NAI C 501
source : AC7
5) chain C
residue 15
type
sequence V
description binding site for residue NAI C 501
source : AC7
6) chain C
residue 36
type
sequence D
description binding site for residue NAI C 501
source : AC7
7) chain C
residue 37
type
sequence V
description binding site for residue NAI C 501
source : AC7
8) chain C
residue 41
type
sequence R
description binding site for residue NAI C 501
source : AC7
9) chain C
residue 88
type
sequence S
description binding site for residue NAI C 501
source : AC7
10) chain C
residue 89
type
sequence V
description binding site for residue NAI C 501
source : AC7
11) chain C
residue 90
type
sequence N
description binding site for residue NAI C 501
source : AC7
12) chain C
residue 91
type
sequence T
description binding site for residue NAI C 501
source : AC7
13) chain C
residue 108
type
sequence Y
description binding site for residue NAI C 501
source : AC7
14) chain C
residue 130
type
sequence S
description binding site for residue NAI C 501
source : AC7
15) chain C
residue 131
type
sequence T
description binding site for residue NAI C 501
source : AC7
16) chain C
residue 161
type
sequence E
description binding site for residue NAI C 501
source : AC7
17) chain C
residue 163
type
sequence L
description binding site for residue NAI C 501
source : AC7
18) chain C
residue 165
type
sequence E
description binding site for residue NAI C 501
source : AC7
19) chain C
residue 276
type
sequence C
description binding site for residue NAI C 501
source : AC7
20) chain C
residue 279
type
sequence K
description binding site for residue NAI C 501
source : AC7
21) chain C
residue 346
type
sequence R
description binding site for residue NAI C 501
source : AC7
22) chain C
residue 161
type
sequence E
description binding site for residue UPG C 502
source : AC8
23) chain C
residue 162
type
sequence F
description binding site for residue UPG C 502
source : AC8
24) chain C
residue 163
type
sequence L
description binding site for residue UPG C 502
source : AC8
25) chain C
residue 164
type
sequence A
description binding site for residue UPG C 502
source : AC8
26) chain C
residue 165
type
sequence E
description binding site for residue UPG C 502
source : AC8
27) chain C
residue 220
type
sequence K
description binding site for residue UPG C 502
source : AC8
28) chain C
residue 224
type
sequence N
description binding site for residue UPG C 502
source : AC8
29) chain C
residue 231
type
sequence I
description binding site for residue UPG C 502
source : AC8
30) chain C
residue 265
type
sequence F
description binding site for residue UPG C 502
source : AC8
31) chain C
residue 266
type
sequence L
description binding site for residue UPG C 502
source : AC8
32) chain C
residue 267
type
sequence K
description binding site for residue UPG C 502
source : AC8
33) chain C
residue 269
type
sequence S
description binding site for residue UPG C 502
source : AC8
34) chain C
residue 272
type
sequence F
description binding site for residue UPG C 502
source : AC8
35) chain C
residue 273
type
sequence G
description binding site for residue UPG C 502
source : AC8
36) chain C
residue 276
type
sequence C
description binding site for residue UPG C 502
source : AC8
37) chain C
residue 277
type
sequence F
description binding site for residue UPG C 502
source : AC8
38) chain C
residue 338
type
sequence F
description binding site for residue UPG C 502
source : AC8
39) chain C
residue 339
type
sequence K
description binding site for residue UPG C 502
source : AC8
40) chain C
residue 442
type
sequence R
description binding site for residue UPG C 502
source : AC8
41) chain C
residue 162
type
sequence F
description binding site for residue DMS C 503
source : AC9
42) chain C
residue 171
type
sequence D
description binding site for residue DMS C 503
source : AC9
43) chain C
residue 260
type
sequence R
description binding site for residue UPG D 501
source : AD2
44) chain C
residue 276
type ACT_SITE
sequence C
description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI2
45) chain C
residue 161
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1
46) chain C
residue 220
type ACT_SITE
sequence K
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1
47) chain C
residue 11
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
48) chain C
residue 36
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
49) chain C
residue 41
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
50) chain C
residue 89
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
51) chain C
residue 276
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
52) chain C
residue 130
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445
source Swiss-Prot : SWS_FT_FI4
53) chain C
residue 220
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
54) chain C
residue 267
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
55) chain C
residue 338
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
56) chain C
residue 161
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
57) chain C
residue 165
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4
source Swiss-Prot : SWS_FT_FI6
58) chain C
residue 260
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH
source Swiss-Prot : SWS_FT_FI7
59) chain C
residue 346
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI8
60) chain C
residue 442
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI9
61) chain C
residue 107
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI10

Display surface

Download
Links