eF-site ID 6c4j-K PDB Code 6c4j Chain K click to enlarge Title Ligand bound full length hUGDH with A104L substitution Classification OXIDOREDUCTASE Compound UDP-glucose 6-dehydrogenase Source (UGDH_HUMAN) Sequence K:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK EADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNS NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD GLHNELQTIGFQIETIGKKV Description Functional site 1) chain K residue 31 type sequence R description binding site for residue SO4 D 504 source : AD5 2) chain K residue 70 type sequence F description binding site for residue SO4 D 504 source : AD5 3) chain K residue 10 type sequence I description binding site for residue NAD K 501 source : AG5 4) chain K residue 11 type sequence G description binding site for residue NAD K 501 source : AG5 5) chain K residue 13 type sequence G description binding site for residue NAD K 501 source : AG5 6) chain K residue 14 type sequence Y description binding site for residue NAD K 501 source : AG5 7) chain K residue 15 type sequence V description binding site for residue NAD K 501 source : AG5 8) chain K residue 36 type sequence D description binding site for residue NAD K 501 source : AG5 9) chain K residue 37 type sequence V description binding site for residue NAD K 501 source : AG5 10) chain K residue 41 type sequence R description binding site for residue NAD K 501 source : AG5 11) chain K residue 88 type sequence S description binding site for residue NAD K 501 source : AG5 12) chain K residue 89 type sequence V description binding site for residue NAD K 501 source : AG5 13) chain K residue 90 type sequence N description binding site for residue NAD K 501 source : AG5 14) chain K residue 91 type sequence T description binding site for residue NAD K 501 source : AG5 15) chain K residue 108 type sequence Y description binding site for residue NAD K 501 source : AG5 16) chain K residue 130 type sequence S description binding site for residue NAD K 501 source : AG5 17) chain K residue 131 type sequence T description binding site for residue NAD K 501 source : AG5 18) chain K residue 161 type sequence E description binding site for residue NAD K 501 source : AG5 19) chain K residue 163 type sequence L description binding site for residue NAD K 501 source : AG5 20) chain K residue 279 type sequence K description binding site for residue NAD K 501 source : AG5 21) chain K residue 162 type sequence F description binding site for residue UPG K 502 source : AG6 22) chain K residue 163 type sequence L description binding site for residue UPG K 502 source : AG6 23) chain K residue 164 type sequence A description binding site for residue UPG K 502 source : AG6 24) chain K residue 165 type sequence E description binding site for residue UPG K 502 source : AG6 25) chain K residue 220 type sequence K description binding site for residue UPG K 502 source : AG6 26) chain K residue 224 type sequence N description binding site for residue UPG K 502 source : AG6 27) chain K residue 231 type sequence I description binding site for residue UPG K 502 source : AG6 28) chain K residue 265 type sequence F description binding site for residue UPG K 502 source : AG6 29) chain K residue 266 type sequence L description binding site for residue UPG K 502 source : AG6 30) chain K residue 267 type sequence K description binding site for residue UPG K 502 source : AG6 31) chain K residue 269 type sequence S description binding site for residue UPG K 502 source : AG6 32) chain K residue 272 type sequence F description binding site for residue UPG K 502 source : AG6 33) chain K residue 273 type sequence G description binding site for residue UPG K 502 source : AG6 34) chain K residue 276 type sequence C description binding site for residue UPG K 502 source : AG6 35) chain K residue 277 type sequence F description binding site for residue UPG K 502 source : AG6 36) chain K residue 338 type sequence F description binding site for residue UPG K 502 source : AG6 37) chain K residue 339 type sequence K description binding site for residue UPG K 502 source : AG6 38) chain K residue 442 type sequence R description binding site for residue UPG K 502 source : AG6 39) chain K residue 56 type sequence G description binding site for residue CL K 503 source : AG7 40) chain K residue 99 type sequence G description binding site for residue CL K 504 source : AG8 41) chain K residue 102 type sequence R description binding site for residue CL K 504 source : AG8 42) chain K residue 135 type sequence R description binding site for residue SO4 K 505 source : AG9 43) chain K residue 214 type sequence W description binding site for residue SO4 K 505 source : AG9 44) chain K residue 162 type sequence F description binding site for residue PGO K 506 source : AH1 45) chain K residue 171 type sequence D description binding site for residue PGO K 506 source : AH1 46) chain K residue 176 type sequence D description binding site for residue PGO K 506 source : AH1 47) chain K residue 260 type sequence R description binding site for residue UPG L 502 source : AH3 48) chain K residue 258 type sequence D description binding site for residue PGO L 505 source : AH6 49) chain K residue 260 type sequence R description binding site for residue PGO L 505 source : AH6 50) chain K residue 346 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI8 51) chain K residue 442 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI9 52) chain K residue 107 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI10 53) chain K residue 161 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 54) chain K residue 220 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 55) chain K residue 276 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI2 56) chain K residue 11 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 57) chain K residue 36 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 58) chain K residue 41 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 59) chain K residue 89 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 60) chain K residue 276 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 61) chain K residue 130 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 source Swiss-Prot : SWS_FT_FI4 62) chain K residue 161 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 63) chain K residue 220 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 64) chain K residue 267 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 65) chain K residue 338 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 66) chain K residue 165 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 source Swiss-Prot : SWS_FT_FI6 67) chain K residue 260 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH source Swiss-Prot : SWS_FT_FI7

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