eF-site ID 6c4j-J PDB Code 6c4j Chain J click to enlarge Title Ligand bound full length hUGDH with A104L substitution Classification OXIDOREDUCTASE Compound UDP-glucose 6-dehydrogenase Source (UGDH_HUMAN) Sequence J:  FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESR INAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKE ADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNSN GYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPE FLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEH WVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALC EATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDV LNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDS LFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEG AHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGA HAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGL HNELQTIGFQIETIGKKV Description Functional site 1) chain J residue 260 type sequence R description binding site for residue UPG I 502 source : AF8 2) chain J residue 10 type sequence I description binding site for residue NAD J 501 source : AG2 3) chain J residue 11 type sequence G description binding site for residue NAD J 501 source : AG2 4) chain J residue 13 type sequence G description binding site for residue NAD J 501 source : AG2 5) chain J residue 14 type sequence Y description binding site for residue NAD J 501 source : AG2 6) chain J residue 15 type sequence V description binding site for residue NAD J 501 source : AG2 7) chain J residue 36 type sequence D description binding site for residue NAD J 501 source : AG2 8) chain J residue 37 type sequence V description binding site for residue NAD J 501 source : AG2 9) chain J residue 41 type sequence R description binding site for residue NAD J 501 source : AG2 10) chain J residue 88 type sequence S description binding site for residue NAD J 501 source : AG2 11) chain J residue 89 type sequence V description binding site for residue NAD J 501 source : AG2 12) chain J residue 90 type sequence N description binding site for residue NAD J 501 source : AG2 13) chain J residue 91 type sequence T description binding site for residue NAD J 501 source : AG2 14) chain J residue 108 type sequence Y description binding site for residue NAD J 501 source : AG2 15) chain J residue 130 type sequence S description binding site for residue NAD J 501 source : AG2 16) chain J residue 131 type sequence T description binding site for residue NAD J 501 source : AG2 17) chain J residue 161 type sequence E description binding site for residue NAD J 501 source : AG2 18) chain J residue 165 type sequence E description binding site for residue NAD J 501 source : AG2 19) chain J residue 276 type sequence C description binding site for residue NAD J 501 source : AG2 20) chain J residue 279 type sequence K description binding site for residue NAD J 501 source : AG2 21) chain J residue 346 type sequence R description binding site for residue NAD J 501 source : AG2 22) chain J residue 161 type sequence E description binding site for residue UPG J 502 source : AG3 23) chain J residue 162 type sequence F description binding site for residue UPG J 502 source : AG3 24) chain J residue 163 type sequence L description binding site for residue UPG J 502 source : AG3 25) chain J residue 164 type sequence A description binding site for residue UPG J 502 source : AG3 26) chain J residue 165 type sequence E description binding site for residue UPG J 502 source : AG3 27) chain J residue 220 type sequence K description binding site for residue UPG J 502 source : AG3 28) chain J residue 224 type sequence N description binding site for residue UPG J 502 source : AG3 29) chain J residue 231 type sequence I description binding site for residue UPG J 502 source : AG3 30) chain J residue 265 type sequence F description binding site for residue UPG J 502 source : AG3 31) chain J residue 266 type sequence L description binding site for residue UPG J 502 source : AG3 32) chain J residue 267 type sequence K description binding site for residue UPG J 502 source : AG3 33) chain J residue 269 type sequence S description binding site for residue UPG J 502 source : AG3 34) chain J residue 272 type sequence F description binding site for residue UPG J 502 source : AG3 35) chain J residue 273 type sequence G description binding site for residue UPG J 502 source : AG3 36) chain J residue 276 type sequence C description binding site for residue UPG J 502 source : AG3 37) chain J residue 277 type sequence F description binding site for residue UPG J 502 source : AG3 38) chain J residue 338 type sequence F description binding site for residue UPG J 502 source : AG3 39) chain J residue 339 type sequence K description binding site for residue UPG J 502 source : AG3 40) chain J residue 442 type sequence R description binding site for residue UPG J 502 source : AG3 41) chain J residue 135 type sequence R description binding site for residue CL J 503 source : AG4 42) chain J residue 161 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 43) chain J residue 220 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 44) chain J residue 276 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI2 45) chain J residue 11 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 46) chain J residue 36 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 47) chain J residue 41 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 48) chain J residue 89 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 49) chain J residue 276 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 50) chain J residue 130 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 source Swiss-Prot : SWS_FT_FI4 51) chain J residue 161 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 52) chain J residue 220 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 53) chain J residue 267 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 54) chain J residue 338 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 55) chain J residue 165 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 source Swiss-Prot : SWS_FT_FI6 56) chain J residue 107 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI10 57) chain J residue 260 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH source Swiss-Prot : SWS_FT_FI7 58) chain J residue 346 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI8 59) chain J residue 442 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI9

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