eF-site ID 6c4j-I
PDB Code 6c4j
Chain I

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Title Ligand bound full length hUGDH with A104L substitution
Classification OXIDOREDUCTASE
Compound UDP-glucose 6-dehydrogenase
Source (UGDH_HUMAN)
Sequence I:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES
RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK
EADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNS
NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP
EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE
HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL
CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD
VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID
SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE
GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD
GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD
GLHNELQTIGFQIETIGKKV
Description


Functional site
1) chain I
residue 10
type
sequence I
description binding site for residue NAD I 501
source : AF7
2) chain I
residue 11
type
sequence G
description binding site for residue NAD I 501
source : AF7
3) chain I
residue 13
type
sequence G
description binding site for residue NAD I 501
source : AF7
4) chain I
residue 14
type
sequence Y
description binding site for residue NAD I 501
source : AF7
5) chain I
residue 15
type
sequence V
description binding site for residue NAD I 501
source : AF7
6) chain I
residue 36
type
sequence D
description binding site for residue NAD I 501
source : AF7
7) chain I
residue 37
type
sequence V
description binding site for residue NAD I 501
source : AF7
8) chain I
residue 41
type
sequence R
description binding site for residue NAD I 501
source : AF7
9) chain I
residue 88
type
sequence S
description binding site for residue NAD I 501
source : AF7
10) chain I
residue 89
type
sequence V
description binding site for residue NAD I 501
source : AF7
11) chain I
residue 90
type
sequence N
description binding site for residue NAD I 501
source : AF7
12) chain I
residue 91
type
sequence T
description binding site for residue NAD I 501
source : AF7
13) chain I
residue 108
type
sequence Y
description binding site for residue NAD I 501
source : AF7
14) chain I
residue 130
type
sequence S
description binding site for residue NAD I 501
source : AF7
15) chain I
residue 131
type
sequence T
description binding site for residue NAD I 501
source : AF7
16) chain I
residue 161
type
sequence E
description binding site for residue NAD I 501
source : AF7
17) chain I
residue 165
type
sequence E
description binding site for residue NAD I 501
source : AF7
18) chain I
residue 162
type
sequence F
description binding site for residue UPG I 502
source : AF8
19) chain I
residue 163
type
sequence L
description binding site for residue UPG I 502
source : AF8
20) chain I
residue 164
type
sequence A
description binding site for residue UPG I 502
source : AF8
21) chain I
residue 165
type
sequence E
description binding site for residue UPG I 502
source : AF8
22) chain I
residue 220
type
sequence K
description binding site for residue UPG I 502
source : AF8
23) chain I
residue 224
type
sequence N
description binding site for residue UPG I 502
source : AF8
24) chain I
residue 231
type
sequence I
description binding site for residue UPG I 502
source : AF8
25) chain I
residue 265
type
sequence F
description binding site for residue UPG I 502
source : AF8
26) chain I
residue 266
type
sequence L
description binding site for residue UPG I 502
source : AF8
27) chain I
residue 267
type
sequence K
description binding site for residue UPG I 502
source : AF8
28) chain I
residue 269
type
sequence S
description binding site for residue UPG I 502
source : AF8
29) chain I
residue 272
type
sequence F
description binding site for residue UPG I 502
source : AF8
30) chain I
residue 273
type
sequence G
description binding site for residue UPG I 502
source : AF8
31) chain I
residue 276
type
sequence C
description binding site for residue UPG I 502
source : AF8
32) chain I
residue 277
type
sequence F
description binding site for residue UPG I 502
source : AF8
33) chain I
residue 338
type
sequence F
description binding site for residue UPG I 502
source : AF8
34) chain I
residue 339
type
sequence K
description binding site for residue UPG I 502
source : AF8
35) chain I
residue 442
type
sequence R
description binding site for residue UPG I 502
source : AF8
36) chain I
residue 99
type
sequence G
description binding site for residue CL I 503
source : AF9
37) chain I
residue 102
type
sequence R
description binding site for residue CL I 503
source : AF9
38) chain I
residue 135
type
sequence R
description binding site for residue CL I 504
source : AG1
39) chain I
residue 260
type
sequence R
description binding site for residue UPG J 502
source : AG3
40) chain I
residue 161
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1
41) chain I
residue 220
type ACT_SITE
sequence K
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1
42) chain I
residue 276
type ACT_SITE
sequence C
description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI2
43) chain I
residue 11
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
44) chain I
residue 36
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
45) chain I
residue 41
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
46) chain I
residue 89
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
47) chain I
residue 276
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
48) chain I
residue 130
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445
source Swiss-Prot : SWS_FT_FI4
49) chain I
residue 161
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
50) chain I
residue 220
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
51) chain I
residue 267
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
52) chain I
residue 338
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
53) chain I
residue 165
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4
source Swiss-Prot : SWS_FT_FI6
54) chain I
residue 107
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI10
55) chain I
residue 260
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH
source Swiss-Prot : SWS_FT_FI7
56) chain I
residue 346
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI8
57) chain I
residue 442
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI9

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