eF-site ID 6c4j-H
PDB Code 6c4j
Chain H

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Title Ligand bound full length hUGDH with A104L substitution
Classification OXIDOREDUCTASE
Compound UDP-glucose 6-dehydrogenase
Source (UGDH_HUMAN)
Sequence H:  FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESR
INAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKE
ADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNSN
GYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPE
FLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEH
WVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALC
EATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDV
LNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDS
LFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEG
AHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACDG
AHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDG
LHNELQTIGFQIETIGKKV
Description


Functional site
1) chain H
residue 260
type
sequence R
description binding site for residue UPG G 502
source : AE9
2) chain H
residue 258
type
sequence D
description binding site for residue PGO G 505
source : AF3
3) chain H
residue 260
type
sequence R
description binding site for residue PGO G 505
source : AF3
4) chain H
residue 10
type
sequence I
description binding site for residue NAD H 501
source : AF4
5) chain H
residue 11
type
sequence G
description binding site for residue NAD H 501
source : AF4
6) chain H
residue 13
type
sequence G
description binding site for residue NAD H 501
source : AF4
7) chain H
residue 14
type
sequence Y
description binding site for residue NAD H 501
source : AF4
8) chain H
residue 15
type
sequence V
description binding site for residue NAD H 501
source : AF4
9) chain H
residue 36
type
sequence D
description binding site for residue NAD H 501
source : AF4
10) chain H
residue 37
type
sequence V
description binding site for residue NAD H 501
source : AF4
11) chain H
residue 41
type
sequence R
description binding site for residue NAD H 501
source : AF4
12) chain H
residue 88
type
sequence S
description binding site for residue NAD H 501
source : AF4
13) chain H
residue 89
type
sequence V
description binding site for residue NAD H 501
source : AF4
14) chain H
residue 90
type
sequence N
description binding site for residue NAD H 501
source : AF4
15) chain H
residue 91
type
sequence T
description binding site for residue NAD H 501
source : AF4
16) chain H
residue 108
type
sequence Y
description binding site for residue NAD H 501
source : AF4
17) chain H
residue 130
type
sequence S
description binding site for residue NAD H 501
source : AF4
18) chain H
residue 131
type
sequence T
description binding site for residue NAD H 501
source : AF4
19) chain H
residue 161
type
sequence E
description binding site for residue NAD H 501
source : AF4
20) chain H
residue 279
type
sequence K
description binding site for residue NAD H 501
source : AF4
21) chain H
residue 162
type
sequence F
description binding site for residue UPG H 502
source : AF5
22) chain H
residue 163
type
sequence L
description binding site for residue UPG H 502
source : AF5
23) chain H
residue 164
type
sequence A
description binding site for residue UPG H 502
source : AF5
24) chain H
residue 165
type
sequence E
description binding site for residue UPG H 502
source : AF5
25) chain H
residue 220
type
sequence K
description binding site for residue UPG H 502
source : AF5
26) chain H
residue 224
type
sequence N
description binding site for residue UPG H 502
source : AF5
27) chain H
residue 231
type
sequence I
description binding site for residue UPG H 502
source : AF5
28) chain H
residue 265
type
sequence F
description binding site for residue UPG H 502
source : AF5
29) chain H
residue 266
type
sequence L
description binding site for residue UPG H 502
source : AF5
30) chain H
residue 267
type
sequence K
description binding site for residue UPG H 502
source : AF5
31) chain H
residue 269
type
sequence S
description binding site for residue UPG H 502
source : AF5
32) chain H
residue 272
type
sequence F
description binding site for residue UPG H 502
source : AF5
33) chain H
residue 273
type
sequence G
description binding site for residue UPG H 502
source : AF5
34) chain H
residue 276
type
sequence C
description binding site for residue UPG H 502
source : AF5
35) chain H
residue 277
type
sequence F
description binding site for residue UPG H 502
source : AF5
36) chain H
residue 338
type
sequence F
description binding site for residue UPG H 502
source : AF5
37) chain H
residue 339
type
sequence K
description binding site for residue UPG H 502
source : AF5
38) chain H
residue 442
type
sequence R
description binding site for residue UPG H 502
source : AF5
39) chain H
residue 135
type
sequence R
description binding site for residue CL H 503
source : AF6
40) chain H
residue 161
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1
41) chain H
residue 220
type ACT_SITE
sequence K
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1
42) chain H
residue 276
type ACT_SITE
sequence C
description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI2
43) chain H
residue 11
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
44) chain H
residue 36
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
45) chain H
residue 41
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
46) chain H
residue 89
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
47) chain H
residue 276
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
48) chain H
residue 130
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445
source Swiss-Prot : SWS_FT_FI4
49) chain H
residue 161
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
50) chain H
residue 220
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
51) chain H
residue 267
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
52) chain H
residue 338
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
53) chain H
residue 165
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4
source Swiss-Prot : SWS_FT_FI6
54) chain H
residue 107
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI10
55) chain H
residue 260
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH
source Swiss-Prot : SWS_FT_FI7
56) chain H
residue 346
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI8
57) chain H
residue 442
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI9

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