eF-site ID 6c4j-G PDB Code 6c4j Chain G click to enlarge Title Ligand bound full length hUGDH with A104L substitution Classification OXIDOREDUCTASE Compound UDP-glucose 6-dehydrogenase Source (UGDH_HUMAN) Sequence G:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK EADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNS NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD GLHNELQTIGFQIETIGKKV Description Functional site 1) chain G residue 10 type sequence I description binding site for residue NAD G 501 source : AE8 2) chain G residue 11 type sequence G description binding site for residue NAD G 501 source : AE8 3) chain G residue 13 type sequence G description binding site for residue NAD G 501 source : AE8 4) chain G residue 14 type sequence Y description binding site for residue NAD G 501 source : AE8 5) chain G residue 15 type sequence V description binding site for residue NAD G 501 source : AE8 6) chain G residue 36 type sequence D description binding site for residue NAD G 501 source : AE8 7) chain G residue 37 type sequence V description binding site for residue NAD G 501 source : AE8 8) chain G residue 41 type sequence R description binding site for residue NAD G 501 source : AE8 9) chain G residue 88 type sequence S description binding site for residue NAD G 501 source : AE8 10) chain G residue 89 type sequence V description binding site for residue NAD G 501 source : AE8 11) chain G residue 90 type sequence N description binding site for residue NAD G 501 source : AE8 12) chain G residue 91 type sequence T description binding site for residue NAD G 501 source : AE8 13) chain G residue 108 type sequence Y description binding site for residue NAD G 501 source : AE8 14) chain G residue 130 type sequence S description binding site for residue NAD G 501 source : AE8 15) chain G residue 131 type sequence T description binding site for residue NAD G 501 source : AE8 16) chain G residue 161 type sequence E description binding site for residue NAD G 501 source : AE8 17) chain G residue 165 type sequence E description binding site for residue NAD G 501 source : AE8 18) chain G residue 276 type sequence C description binding site for residue NAD G 501 source : AE8 19) chain G residue 279 type sequence K description binding site for residue NAD G 501 source : AE8 20) chain G residue 346 type sequence R description binding site for residue NAD G 501 source : AE8 21) chain G residue 161 type sequence E description binding site for residue UPG G 502 source : AE9 22) chain G residue 162 type sequence F description binding site for residue UPG G 502 source : AE9 23) chain G residue 163 type sequence L description binding site for residue UPG G 502 source : AE9 24) chain G residue 164 type sequence A description binding site for residue UPG G 502 source : AE9 25) chain G residue 165 type sequence E description binding site for residue UPG G 502 source : AE9 26) chain G residue 220 type sequence K description binding site for residue UPG G 502 source : AE9 27) chain G residue 224 type sequence N description binding site for residue UPG G 502 source : AE9 28) chain G residue 231 type sequence I description binding site for residue UPG G 502 source : AE9 29) chain G residue 265 type sequence F description binding site for residue UPG G 502 source : AE9 30) chain G residue 266 type sequence L description binding site for residue UPG G 502 source : AE9 31) chain G residue 267 type sequence K description binding site for residue UPG G 502 source : AE9 32) chain G residue 269 type sequence S description binding site for residue UPG G 502 source : AE9 33) chain G residue 272 type sequence F description binding site for residue UPG G 502 source : AE9 34) chain G residue 273 type sequence G description binding site for residue UPG G 502 source : AE9 35) chain G residue 276 type sequence C description binding site for residue UPG G 502 source : AE9 36) chain G residue 277 type sequence F description binding site for residue UPG G 502 source : AE9 37) chain G residue 338 type sequence F description binding site for residue UPG G 502 source : AE9 38) chain G residue 339 type sequence K description binding site for residue UPG G 502 source : AE9 39) chain G residue 442 type sequence R description binding site for residue UPG G 502 source : AE9 40) chain G residue 135 type sequence R description binding site for residue CL G 503 source : AF1 41) chain G residue 214 type sequence W description binding site for residue CL G 503 source : AF1 42) chain G residue 263 type sequence N description binding site for residue SO4 G 504 source : AF2 43) chain G residue 264 type sequence K description binding site for residue SO4 G 504 source : AF2 44) chain G residue 162 type sequence F description binding site for residue PGO G 505 source : AF3 45) chain G residue 171 type sequence D description binding site for residue PGO G 505 source : AF3 46) chain G residue 176 type sequence D description binding site for residue PGO G 505 source : AF3 47) chain G residue 260 type sequence R description binding site for residue UPG H 502 source : AF5 48) chain G residue 346 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI8 49) chain G residue 442 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI9 50) chain G residue 107 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI10 51) chain G residue 161 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 52) chain G residue 220 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 53) chain G residue 276 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI2 54) chain G residue 11 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 55) chain G residue 36 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 56) chain G residue 41 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 57) chain G residue 89 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 58) chain G residue 276 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 59) chain G residue 130 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 source Swiss-Prot : SWS_FT_FI4 60) chain G residue 161 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 61) chain G residue 220 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 62) chain G residue 267 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 63) chain G residue 338 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 64) chain G residue 165 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 source Swiss-Prot : SWS_FT_FI6 65) chain G residue 260 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH source Swiss-Prot : SWS_FT_FI7

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