eF-site ID 6c4j-F PDB Code 6c4j Chain F click to enlarge Title Ligand bound full length hUGDH with A104L substitution Classification OXIDOREDUCTASE Compound UDP-glucose 6-dehydrogenase Source (UGDH_HUMAN) Sequence F:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK EADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNS NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD GLHNELQTIGFQIETIGKKV Description Functional site 1) chain F residue 260 type sequence R description binding site for residue UPG E 502 source : AD9 2) chain F residue 10 type sequence I description binding site for residue NAD F 501 source : AE3 3) chain F residue 11 type sequence G description binding site for residue NAD F 501 source : AE3 4) chain F residue 13 type sequence G description binding site for residue NAD F 501 source : AE3 5) chain F residue 14 type sequence Y description binding site for residue NAD F 501 source : AE3 6) chain F residue 15 type sequence V description binding site for residue NAD F 501 source : AE3 7) chain F residue 36 type sequence D description binding site for residue NAD F 501 source : AE3 8) chain F residue 37 type sequence V description binding site for residue NAD F 501 source : AE3 9) chain F residue 41 type sequence R description binding site for residue NAD F 501 source : AE3 10) chain F residue 75 type sequence I description binding site for residue NAD F 501 source : AE3 11) chain F residue 88 type sequence S description binding site for residue NAD F 501 source : AE3 12) chain F residue 89 type sequence V description binding site for residue NAD F 501 source : AE3 13) chain F residue 90 type sequence N description binding site for residue NAD F 501 source : AE3 14) chain F residue 91 type sequence T description binding site for residue NAD F 501 source : AE3 15) chain F residue 130 type sequence S description binding site for residue NAD F 501 source : AE3 16) chain F residue 131 type sequence T description binding site for residue NAD F 501 source : AE3 17) chain F residue 275 type sequence S description binding site for residue NAD F 501 source : AE3 18) chain F residue 279 type sequence K description binding site for residue NAD F 501 source : AE3 19) chain F residue 162 type sequence F description binding site for residue UPG F 502 source : AE4 20) chain F residue 163 type sequence L description binding site for residue UPG F 502 source : AE4 21) chain F residue 164 type sequence A description binding site for residue UPG F 502 source : AE4 22) chain F residue 165 type sequence E description binding site for residue UPG F 502 source : AE4 23) chain F residue 220 type sequence K description binding site for residue UPG F 502 source : AE4 24) chain F residue 224 type sequence N description binding site for residue UPG F 502 source : AE4 25) chain F residue 231 type sequence I description binding site for residue UPG F 502 source : AE4 26) chain F residue 265 type sequence F description binding site for residue UPG F 502 source : AE4 27) chain F residue 266 type sequence L description binding site for residue UPG F 502 source : AE4 28) chain F residue 267 type sequence K description binding site for residue UPG F 502 source : AE4 29) chain F residue 269 type sequence S description binding site for residue UPG F 502 source : AE4 30) chain F residue 272 type sequence F description binding site for residue UPG F 502 source : AE4 31) chain F residue 273 type sequence G description binding site for residue UPG F 502 source : AE4 32) chain F residue 276 type sequence C description binding site for residue UPG F 502 source : AE4 33) chain F residue 277 type sequence F description binding site for residue UPG F 502 source : AE4 34) chain F residue 338 type sequence F description binding site for residue UPG F 502 source : AE4 35) chain F residue 339 type sequence K description binding site for residue UPG F 502 source : AE4 36) chain F residue 442 type sequence R description binding site for residue UPG F 502 source : AE4 37) chain F residue 97 type sequence G description binding site for residue SO4 F 503 source : AE5 38) chain F residue 98 type sequence M description binding site for residue SO4 F 503 source : AE5 39) chain F residue 99 type sequence G description binding site for residue SO4 F 503 source : AE5 40) chain F residue 102 type sequence R description binding site for residue SO4 F 503 source : AE5 41) chain F residue 135 type sequence R description binding site for residue SO4 F 504 source : AE6 42) chain F residue 214 type sequence W description binding site for residue SO4 F 504 source : AE6 43) chain F residue 162 type sequence F description binding site for residue PGO F 505 source : AE7 44) chain F residue 171 type sequence D description binding site for residue PGO F 505 source : AE7 45) chain F residue 176 type sequence D description binding site for residue PGO F 505 source : AE7 46) chain F residue 31 type sequence R description binding site for residue SO4 G 504 source : AF2 47) chain F residue 70 type sequence F description binding site for residue SO4 G 504 source : AF2 48) chain F residue 346 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI8 49) chain F residue 442 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI9 50) chain F residue 107 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI10 51) chain F residue 161 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 52) chain F residue 220 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 53) chain F residue 276 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI2 54) chain F residue 11 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 55) chain F residue 36 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 56) chain F residue 41 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 57) chain F residue 89 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 58) chain F residue 276 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 59) chain F residue 130 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 source Swiss-Prot : SWS_FT_FI4 60) chain F residue 267 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 61) chain F residue 338 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 62) chain F residue 161 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 63) chain F residue 220 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 64) chain F residue 165 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 source Swiss-Prot : SWS_FT_FI6 65) chain F residue 260 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH source Swiss-Prot : SWS_FT_FI7

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