eF-site ID 6c4j-E PDB Code 6c4j Chain E click to enlarge Title Ligand bound full length hUGDH with A104L substitution Classification OXIDOREDUCTASE Compound UDP-glucose 6-dehydrogenase Source (UGDH_HUMAN) Sequence E:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK EADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNS NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD GLHNELQTIGFQIETIGKKV Description Functional site 1) chain E residue 10 type sequence I description binding site for residue NAD E 501 source : AD8 2) chain E residue 11 type sequence G description binding site for residue NAD E 501 source : AD8 3) chain E residue 13 type sequence G description binding site for residue NAD E 501 source : AD8 4) chain E residue 14 type sequence Y description binding site for residue NAD E 501 source : AD8 5) chain E residue 15 type sequence V description binding site for residue NAD E 501 source : AD8 6) chain E residue 36 type sequence D description binding site for residue NAD E 501 source : AD8 7) chain E residue 37 type sequence V description binding site for residue NAD E 501 source : AD8 8) chain E residue 41 type sequence R description binding site for residue NAD E 501 source : AD8 9) chain E residue 88 type sequence S description binding site for residue NAD E 501 source : AD8 10) chain E residue 89 type sequence V description binding site for residue NAD E 501 source : AD8 11) chain E residue 90 type sequence N description binding site for residue NAD E 501 source : AD8 12) chain E residue 91 type sequence T description binding site for residue NAD E 501 source : AD8 13) chain E residue 108 type sequence Y description binding site for residue NAD E 501 source : AD8 14) chain E residue 130 type sequence S description binding site for residue NAD E 501 source : AD8 15) chain E residue 131 type sequence T description binding site for residue NAD E 501 source : AD8 16) chain E residue 161 type sequence E description binding site for residue NAD E 501 source : AD8 17) chain E residue 279 type sequence K description binding site for residue NAD E 501 source : AD8 18) chain E residue 162 type sequence F description binding site for residue UPG E 502 source : AD9 19) chain E residue 163 type sequence L description binding site for residue UPG E 502 source : AD9 20) chain E residue 164 type sequence A description binding site for residue UPG E 502 source : AD9 21) chain E residue 165 type sequence E description binding site for residue UPG E 502 source : AD9 22) chain E residue 220 type sequence K description binding site for residue UPG E 502 source : AD9 23) chain E residue 224 type sequence N description binding site for residue UPG E 502 source : AD9 24) chain E residue 231 type sequence I description binding site for residue UPG E 502 source : AD9 25) chain E residue 265 type sequence F description binding site for residue UPG E 502 source : AD9 26) chain E residue 266 type sequence L description binding site for residue UPG E 502 source : AD9 27) chain E residue 267 type sequence K description binding site for residue UPG E 502 source : AD9 28) chain E residue 269 type sequence S description binding site for residue UPG E 502 source : AD9 29) chain E residue 272 type sequence F description binding site for residue UPG E 502 source : AD9 30) chain E residue 273 type sequence G description binding site for residue UPG E 502 source : AD9 31) chain E residue 276 type sequence C description binding site for residue UPG E 502 source : AD9 32) chain E residue 277 type sequence F description binding site for residue UPG E 502 source : AD9 33) chain E residue 338 type sequence F description binding site for residue UPG E 502 source : AD9 34) chain E residue 339 type sequence K description binding site for residue UPG E 502 source : AD9 35) chain E residue 442 type sequence R description binding site for residue UPG E 502 source : AD9 36) chain E residue 135 type sequence R description binding site for residue SO4 E 503 source : AE1 37) chain E residue 214 type sequence W description binding site for residue SO4 E 503 source : AE1 38) chain E residue 162 type sequence F description binding site for residue PGO E 504 source : AE2 39) chain E residue 171 type sequence D description binding site for residue PGO E 504 source : AE2 40) chain E residue 176 type sequence D description binding site for residue PGO E 504 source : AE2 41) chain E residue 177 type sequence R description binding site for residue PGO E 504 source : AE2 42) chain E residue 260 type sequence R description binding site for residue UPG F 502 source : AE4 43) chain E residue 465 type sequence K description binding site for residue SO4 F 504 source : AE6 44) chain E residue 258 type sequence D description binding site for residue PGO F 505 source : AE7 45) chain E residue 220 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 46) chain E residue 161 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 47) chain E residue 276 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI2 48) chain E residue 11 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 49) chain E residue 36 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 50) chain E residue 41 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 51) chain E residue 89 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 52) chain E residue 276 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 53) chain E residue 130 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 source Swiss-Prot : SWS_FT_FI4 54) chain E residue 161 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 55) chain E residue 220 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 56) chain E residue 267 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 57) chain E residue 338 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 58) chain E residue 165 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 source Swiss-Prot : SWS_FT_FI6 59) chain E residue 107 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI10 60) chain E residue 260 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH source Swiss-Prot : SWS_FT_FI7 61) chain E residue 346 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI8 62) chain E residue 442 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI9

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