eF-site ID 6c4j-D PDB Code 6c4j Chain D click to enlarge Title Ligand bound full length hUGDH with A104L substitution Classification OXIDOREDUCTASE Compound UDP-glucose 6-dehydrogenase Source (UGDH_HUMAN) Sequence D:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK EADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNS NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD GLHNELQTIGFQIETIGKKV Description Functional site 1) chain D residue 260 type sequence R description binding site for residue UPG C 502 source : AC9 2) chain D residue 10 type sequence I description binding site for residue NAD D 501 source : AD2 3) chain D residue 11 type sequence G description binding site for residue NAD D 501 source : AD2 4) chain D residue 13 type sequence G description binding site for residue NAD D 501 source : AD2 5) chain D residue 14 type sequence Y description binding site for residue NAD D 501 source : AD2 6) chain D residue 15 type sequence V description binding site for residue NAD D 501 source : AD2 7) chain D residue 36 type sequence D description binding site for residue NAD D 501 source : AD2 8) chain D residue 37 type sequence V description binding site for residue NAD D 501 source : AD2 9) chain D residue 41 type sequence R description binding site for residue NAD D 501 source : AD2 10) chain D residue 88 type sequence S description binding site for residue NAD D 501 source : AD2 11) chain D residue 89 type sequence V description binding site for residue NAD D 501 source : AD2 12) chain D residue 90 type sequence N description binding site for residue NAD D 501 source : AD2 13) chain D residue 91 type sequence T description binding site for residue NAD D 501 source : AD2 14) chain D residue 108 type sequence Y description binding site for residue NAD D 501 source : AD2 15) chain D residue 130 type sequence S description binding site for residue NAD D 501 source : AD2 16) chain D residue 131 type sequence T description binding site for residue NAD D 501 source : AD2 17) chain D residue 161 type sequence E description binding site for residue NAD D 501 source : AD2 18) chain D residue 279 type sequence K description binding site for residue NAD D 501 source : AD2 19) chain D residue 162 type sequence F description binding site for residue UPG D 502 source : AD3 20) chain D residue 163 type sequence L description binding site for residue UPG D 502 source : AD3 21) chain D residue 164 type sequence A description binding site for residue UPG D 502 source : AD3 22) chain D residue 165 type sequence E description binding site for residue UPG D 502 source : AD3 23) chain D residue 220 type sequence K description binding site for residue UPG D 502 source : AD3 24) chain D residue 224 type sequence N description binding site for residue UPG D 502 source : AD3 25) chain D residue 231 type sequence I description binding site for residue UPG D 502 source : AD3 26) chain D residue 265 type sequence F description binding site for residue UPG D 502 source : AD3 27) chain D residue 266 type sequence L description binding site for residue UPG D 502 source : AD3 28) chain D residue 267 type sequence K description binding site for residue UPG D 502 source : AD3 29) chain D residue 269 type sequence S description binding site for residue UPG D 502 source : AD3 30) chain D residue 272 type sequence F description binding site for residue UPG D 502 source : AD3 31) chain D residue 273 type sequence G description binding site for residue UPG D 502 source : AD3 32) chain D residue 276 type sequence C description binding site for residue UPG D 502 source : AD3 33) chain D residue 277 type sequence F description binding site for residue UPG D 502 source : AD3 34) chain D residue 338 type sequence F description binding site for residue UPG D 502 source : AD3 35) chain D residue 339 type sequence K description binding site for residue UPG D 502 source : AD3 36) chain D residue 442 type sequence R description binding site for residue UPG D 502 source : AD3 37) chain D residue 99 type sequence G description binding site for residue CL D 503 source : AD4 38) chain D residue 102 type sequence R description binding site for residue CL D 503 source : AD4 39) chain D residue 263 type sequence N description binding site for residue SO4 D 504 source : AD5 40) chain D residue 264 type sequence K description binding site for residue SO4 D 504 source : AD5 41) chain D residue 135 type sequence R description binding site for residue SO4 D 505 source : AD6 42) chain D residue 214 type sequence W description binding site for residue SO4 D 505 source : AD6 43) chain D residue 171 type sequence D description binding site for residue PGO D 506 source : AD7 44) chain D residue 176 type sequence D description binding site for residue PGO D 506 source : AD7 45) chain D residue 177 type sequence R description binding site for residue PGO D 506 source : AD7 46) chain D residue 161 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 47) chain D residue 220 type ACT_SITE sequence K description Proton donor/acceptor => ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI1 48) chain D residue 107 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI10 49) chain D residue 276 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 source Swiss-Prot : SWS_FT_FI2 50) chain D residue 11 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 51) chain D residue 36 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 52) chain D residue 41 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 53) chain D residue 89 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 54) chain D residue 276 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI3 55) chain D residue 130 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 source Swiss-Prot : SWS_FT_FI4 56) chain D residue 161 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 57) chain D residue 220 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 58) chain D residue 267 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 59) chain D residue 338 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI5 60) chain D residue 165 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 source Swiss-Prot : SWS_FT_FI6 61) chain D residue 260 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH source Swiss-Prot : SWS_FT_FI7 62) chain D residue 346 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK source Swiss-Prot : SWS_FT_FI8 63) chain D residue 442 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF source Swiss-Prot : SWS_FT_FI9

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