eF-site ID 6c4j-C
PDB Code 6c4j
Chain C

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Title Ligand bound full length hUGDH with A104L substitution
Classification OXIDOREDUCTASE
Compound UDP-glucose 6-dehydrogenase
Source (UGDH_HUMAN)
Sequence C:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES
RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK
EADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNS
NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP
EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE
HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL
CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD
VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID
SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE
GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD
GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD
GLHNELQTIGFQIETIGKKV
Description


Functional site
1) chain C
residue 10
type
sequence I
description binding site for residue NAD C 501
source : AC8
2) chain C
residue 11
type
sequence G
description binding site for residue NAD C 501
source : AC8
3) chain C
residue 13
type
sequence G
description binding site for residue NAD C 501
source : AC8
4) chain C
residue 14
type
sequence Y
description binding site for residue NAD C 501
source : AC8
5) chain C
residue 15
type
sequence V
description binding site for residue NAD C 501
source : AC8
6) chain C
residue 36
type
sequence D
description binding site for residue NAD C 501
source : AC8
7) chain C
residue 37
type
sequence V
description binding site for residue NAD C 501
source : AC8
8) chain C
residue 41
type
sequence R
description binding site for residue NAD C 501
source : AC8
9) chain C
residue 89
type
sequence V
description binding site for residue NAD C 501
source : AC8
10) chain C
residue 90
type
sequence N
description binding site for residue NAD C 501
source : AC8
11) chain C
residue 91
type
sequence T
description binding site for residue NAD C 501
source : AC8
12) chain C
residue 108
type
sequence Y
description binding site for residue NAD C 501
source : AC8
13) chain C
residue 130
type
sequence S
description binding site for residue NAD C 501
source : AC8
14) chain C
residue 131
type
sequence T
description binding site for residue NAD C 501
source : AC8
15) chain C
residue 161
type
sequence E
description binding site for residue NAD C 501
source : AC8
16) chain C
residue 279
type
sequence K
description binding site for residue NAD C 501
source : AC8
17) chain C
residue 162
type
sequence F
description binding site for residue UPG C 502
source : AC9
18) chain C
residue 163
type
sequence L
description binding site for residue UPG C 502
source : AC9
19) chain C
residue 165
type
sequence E
description binding site for residue UPG C 502
source : AC9
20) chain C
residue 220
type
sequence K
description binding site for residue UPG C 502
source : AC9
21) chain C
residue 224
type
sequence N
description binding site for residue UPG C 502
source : AC9
22) chain C
residue 231
type
sequence I
description binding site for residue UPG C 502
source : AC9
23) chain C
residue 265
type
sequence F
description binding site for residue UPG C 502
source : AC9
24) chain C
residue 266
type
sequence L
description binding site for residue UPG C 502
source : AC9
25) chain C
residue 267
type
sequence K
description binding site for residue UPG C 502
source : AC9
26) chain C
residue 269
type
sequence S
description binding site for residue UPG C 502
source : AC9
27) chain C
residue 272
type
sequence F
description binding site for residue UPG C 502
source : AC9
28) chain C
residue 273
type
sequence G
description binding site for residue UPG C 502
source : AC9
29) chain C
residue 276
type
sequence C
description binding site for residue UPG C 502
source : AC9
30) chain C
residue 277
type
sequence F
description binding site for residue UPG C 502
source : AC9
31) chain C
residue 338
type
sequence F
description binding site for residue UPG C 502
source : AC9
32) chain C
residue 339
type
sequence K
description binding site for residue UPG C 502
source : AC9
33) chain C
residue 442
type
sequence R
description binding site for residue UPG C 502
source : AC9
34) chain C
residue 135
type
sequence R
description binding site for residue SO4 C 503
source : AD1
35) chain C
residue 214
type
sequence W
description binding site for residue SO4 C 503
source : AD1
36) chain C
residue 260
type
sequence R
description binding site for residue UPG D 502
source : AD3
37) chain C
residue 465
type
sequence K
description binding site for residue SO4 D 505
source : AD6
38) chain C
residue 258
type
sequence D
description binding site for residue PGO D 506
source : AD7
39) chain C
residue 260
type
sequence R
description binding site for residue PGO D 506
source : AD7
40) chain C
residue 161
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1
41) chain C
residue 220
type ACT_SITE
sequence K
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1
42) chain C
residue 276
type ACT_SITE
sequence C
description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI2
43) chain C
residue 11
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
44) chain C
residue 36
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
45) chain C
residue 41
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
46) chain C
residue 89
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
47) chain C
residue 276
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3
48) chain C
residue 130
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445
source Swiss-Prot : SWS_FT_FI4
49) chain C
residue 220
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
50) chain C
residue 267
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
51) chain C
residue 338
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
52) chain C
residue 161
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5
53) chain C
residue 165
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4
source Swiss-Prot : SWS_FT_FI6
54) chain C
residue 107
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI10
55) chain C
residue 260
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH
source Swiss-Prot : SWS_FT_FI7
56) chain C
residue 346
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI8
57) chain C
residue 442
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI9

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