eF-site ID 6c4j-B
PDB Code 6c4j
Chain B

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Title Ligand bound full length hUGDH with A104L substitution
Classification OXIDOREDUCTASE
Compound UDP-glucose 6-dehydrogenase
Source (UGDH_HUMAN)
Sequence B:  MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNES
RINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIK
EADLVFISVNTPTKTYGMGKGRALDLKYIEACARRIVQNS
NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP
EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYE
HWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL
CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKD
VLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID
SLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE
GAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACD
GAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLD
GLHNELQTIGFQIETIGKKV
Description


Functional site

1) chain B
residue 260
type
sequence R
description binding site for residue UPG A 502
source : AC2

2) chain B
residue 10
type
sequence I
description binding site for residue NAD B 501
source : AC4

3) chain B
residue 11
type
sequence G
description binding site for residue NAD B 501
source : AC4

4) chain B
residue 13
type
sequence G
description binding site for residue NAD B 501
source : AC4

5) chain B
residue 14
type
sequence Y
description binding site for residue NAD B 501
source : AC4

6) chain B
residue 15
type
sequence V
description binding site for residue NAD B 501
source : AC4

7) chain B
residue 36
type
sequence D
description binding site for residue NAD B 501
source : AC4

8) chain B
residue 37
type
sequence V
description binding site for residue NAD B 501
source : AC4

9) chain B
residue 41
type
sequence R
description binding site for residue NAD B 501
source : AC4

10) chain B
residue 75
type
sequence I
description binding site for residue NAD B 501
source : AC4

11) chain B
residue 88
type
sequence S
description binding site for residue NAD B 501
source : AC4

12) chain B
residue 89
type
sequence V
description binding site for residue NAD B 501
source : AC4

13) chain B
residue 90
type
sequence N
description binding site for residue NAD B 501
source : AC4

14) chain B
residue 91
type
sequence T
description binding site for residue NAD B 501
source : AC4

15) chain B
residue 108
type
sequence Y
description binding site for residue NAD B 501
source : AC4

16) chain B
residue 130
type
sequence S
description binding site for residue NAD B 501
source : AC4

17) chain B
residue 131
type
sequence T
description binding site for residue NAD B 501
source : AC4

18) chain B
residue 161
type
sequence E
description binding site for residue NAD B 501
source : AC4

19) chain B
residue 279
type
sequence K
description binding site for residue NAD B 501
source : AC4

20) chain B
residue 162
type
sequence F
description binding site for residue UPG B 502
source : AC5

21) chain B
residue 163
type
sequence L
description binding site for residue UPG B 502
source : AC5

22) chain B
residue 164
type
sequence A
description binding site for residue UPG B 502
source : AC5

23) chain B
residue 165
type
sequence E
description binding site for residue UPG B 502
source : AC5

24) chain B
residue 220
type
sequence K
description binding site for residue UPG B 502
source : AC5

25) chain B
residue 224
type
sequence N
description binding site for residue UPG B 502
source : AC5

26) chain B
residue 231
type
sequence I
description binding site for residue UPG B 502
source : AC5

27) chain B
residue 265
type
sequence F
description binding site for residue UPG B 502
source : AC5

28) chain B
residue 266
type
sequence L
description binding site for residue UPG B 502
source : AC5

29) chain B
residue 267
type
sequence K
description binding site for residue UPG B 502
source : AC5

30) chain B
residue 269
type
sequence S
description binding site for residue UPG B 502
source : AC5

31) chain B
residue 272
type
sequence F
description binding site for residue UPG B 502
source : AC5

32) chain B
residue 273
type
sequence G
description binding site for residue UPG B 502
source : AC5

33) chain B
residue 276
type
sequence C
description binding site for residue UPG B 502
source : AC5

34) chain B
residue 277
type
sequence F
description binding site for residue UPG B 502
source : AC5

35) chain B
residue 338
type
sequence F
description binding site for residue UPG B 502
source : AC5

36) chain B
residue 339
type
sequence K
description binding site for residue UPG B 502
source : AC5

37) chain B
residue 442
type
sequence R
description binding site for residue UPG B 502
source : AC5

38) chain B
residue 99
type
sequence G
description binding site for residue CL B 503
source : AC6

39) chain B
residue 135
type
sequence R
description binding site for residue CL B 504
source : AC7

40) chain B
residue 312
type
sequence R
description binding site for residue SO4 F 503
source : AE5

41) chain B
residue 161
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1

42) chain B
residue 220
type ACT_SITE
sequence K
description Proton donor/acceptor => ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI1

43) chain B
residue 276
type ACT_SITE
sequence C
description Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821
source Swiss-Prot : SWS_FT_FI2

44) chain B
residue 276
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3

45) chain B
residue 11
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3

46) chain B
residue 36
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3

47) chain B
residue 41
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3

48) chain B
residue 89
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI3

49) chain B
residue 130
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445
source Swiss-Prot : SWS_FT_FI4

50) chain B
residue 161
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5

51) chain B
residue 220
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5

52) chain B
residue 267
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5

53) chain B
residue 338
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI5

54) chain B
residue 165
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4
source Swiss-Prot : SWS_FT_FI6

55) chain B
residue 107
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI10

56) chain B
residue 260
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH
source Swiss-Prot : SWS_FT_FI7

57) chain B
residue 346
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK
source Swiss-Prot : SWS_FT_FI8

58) chain B
residue 442
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF
source Swiss-Prot : SWS_FT_FI9


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