eF-site ID 6c2o-A PDB Code 6c2o Chain A click to enlarge Title Crystal structure of HCV NS3/4A protease variant Y56H in complex with danoprevir Classification HYDROLASE/HYDROLASE INHIBITOR Compound NS3 protease Source (C1KIK8_9HEPC) Sequence A:  HMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQ TGRDKNQVEGEVQIVSTATQTFLATSINGVLWTVHHGAGT RTIASPKGPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGS SDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGG PLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTM Description Functional site 1) chain A residue 982 type sequence H description binding site for residue TSV A 1201 source : AC1 2) chain A residue 1041 type sequence Q description binding site for residue TSV A 1201 source : AC1 3) chain A residue 1043 type sequence F description binding site for residue TSV A 1201 source : AC1 4) chain A residue 1057 type sequence H description binding site for residue TSV A 1201 source : AC1 5) chain A residue 1058 type sequence G description binding site for residue TSV A 1201 source : AC1 6) chain A residue 1078 type sequence V description binding site for residue TSV A 1201 source : AC1 7) chain A residue 1079 type sequence D description binding site for residue TSV A 1201 source : AC1 8) chain A residue 1081 type sequence D description binding site for residue TSV A 1201 source : AC1 9) chain A residue 1123 type sequence R description binding site for residue TSV A 1201 source : AC1 10) chain A residue 1135 type sequence L description binding site for residue TSV A 1201 source : AC1 11) chain A residue 1136 type sequence K description binding site for residue TSV A 1201 source : AC1 12) chain A residue 1137 type sequence G description binding site for residue TSV A 1201 source : AC1 13) chain A residue 1138 type sequence S description binding site for residue TSV A 1201 source : AC1 14) chain A residue 1139 type sequence S description binding site for residue TSV A 1201 source : AC1 15) chain A residue 1154 type sequence F description binding site for residue TSV A 1201 source : AC1 16) chain A residue 1155 type sequence R description binding site for residue TSV A 1201 source : AC1 17) chain A residue 1156 type sequence A description binding site for residue TSV A 1201 source : AC1 18) chain A residue 1157 type sequence A description binding site for residue TSV A 1201 source : AC1 19) chain A residue 1168 type sequence D description binding site for residue TSV A 1201 source : AC1 20) chain A residue 1097 type sequence C description binding site for residue ZN A 1202 source : AC2 21) chain A residue 1099 type sequence C description binding site for residue ZN A 1202 source : AC2 22) chain A residue 1145 type sequence C description binding site for residue ZN A 1202 source : AC2 23) chain A residue 1149 type sequence H description binding site for residue ZN A 1202 source : AC2 24) chain A residue 1049 type sequence N description binding site for residue GOL A 1203 source : AC3 25) chain A residue 1121 type sequence D description binding site for residue GOL A 1203 source : AC3 26) chain A residue 1122 type sequence S description binding site for residue GOL A 1203 source : AC3

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