eF-site ID 6c2m-C PDB Code 6c2m Chain C click to enlarge Title Crystal structure of HCV NS3/4A protease variant Y56H in complex with MK-5172 Classification HYDROLASE/HYDROLASE Inhibitor Compound NS3 protease Source (C1KIK8_9HEPC) Sequence C:  KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQ VEGEVQIVSTATQTFLATSINGVLWTVHHGAGTRTIASPK GPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGIFRAAVSTRGVAKAVDFIPVESLETTM Description Functional site 1) chain C residue 1011 type sequence R description binding site for residue SO4 C 1201 source : AC5 2) chain C residue 1012 type sequence G description binding site for residue SO4 C 1201 source : AC5 3) chain C residue 1015 type sequence G description binding site for residue SO4 C 1201 source : AC5 4) chain C residue 1097 type sequence C description binding site for residue ZN C 1202 source : AC6 5) chain C residue 1099 type sequence C description binding site for residue ZN C 1202 source : AC6 6) chain C residue 1145 type sequence C description binding site for residue ZN C 1202 source : AC6 7) chain C residue 1041 type sequence Q description binding site for residue SUE C 1203 source : AC7 8) chain C residue 1056 type sequence H description binding site for residue SUE C 1203 source : AC7 9) chain C residue 1057 type sequence H description binding site for residue SUE C 1203 source : AC7 10) chain C residue 1078 type sequence V description binding site for residue SUE C 1203 source : AC7 11) chain C residue 1081 type sequence D description binding site for residue SUE C 1203 source : AC7 12) chain C residue 1123 type sequence R description binding site for residue SUE C 1203 source : AC7 13) chain C residue 1132 type sequence I description binding site for residue SUE C 1203 source : AC7 14) chain C residue 1135 type sequence L description binding site for residue SUE C 1203 source : AC7 15) chain C residue 1136 type sequence K description binding site for residue SUE C 1203 source : AC7 16) chain C residue 1137 type sequence G description binding site for residue SUE C 1203 source : AC7 17) chain C residue 1138 type sequence S description binding site for residue SUE C 1203 source : AC7 18) chain C residue 1139 type sequence S description binding site for residue SUE C 1203 source : AC7 19) chain C residue 1154 type sequence F description binding site for residue SUE C 1203 source : AC7 20) chain C residue 1155 type sequence R description binding site for residue SUE C 1203 source : AC7 21) chain C residue 1156 type sequence A description binding site for residue SUE C 1203 source : AC7 22) chain C residue 1157 type sequence A description binding site for residue SUE C 1203 source : AC7

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