eF-site ID 6c2m-B PDB Code 6c2m Chain B click to enlarge Title Crystal structure of HCV NS3/4A protease variant Y56H in complex with MK-5172 Classification HYDROLASE/HYDROLASE Inhibitor Compound NS3 protease Source (C1KIK8_9HEPC) Sequence B:  KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQ VEGEVQIVSTATQTFLATSINGVLWTVHHGAGTRTIASPK GPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGIFRAAVSTRGVAKAVDFIPVESLETTM Description Functional site 1) chain B residue 1097 type sequence C description binding site for residue ZN B 1201 source : AC3 2) chain B residue 1099 type sequence C description binding site for residue ZN B 1201 source : AC3 3) chain B residue 1145 type sequence C description binding site for residue ZN B 1201 source : AC3 4) chain B residue 1041 type sequence Q description binding site for residue SUE B 1202 source : AC4 5) chain B residue 1043 type sequence F description binding site for residue SUE B 1202 source : AC4 6) chain B residue 1056 type sequence H description binding site for residue SUE B 1202 source : AC4 7) chain B residue 1057 type sequence H description binding site for residue SUE B 1202 source : AC4 8) chain B residue 1058 type sequence G description binding site for residue SUE B 1202 source : AC4 9) chain B residue 1078 type sequence V description binding site for residue SUE B 1202 source : AC4 10) chain B residue 1081 type sequence D description binding site for residue SUE B 1202 source : AC4 11) chain B residue 1123 type sequence R description binding site for residue SUE B 1202 source : AC4 12) chain B residue 1132 type sequence I description binding site for residue SUE B 1202 source : AC4 13) chain B residue 1135 type sequence L description binding site for residue SUE B 1202 source : AC4 14) chain B residue 1136 type sequence K description binding site for residue SUE B 1202 source : AC4 15) chain B residue 1137 type sequence G description binding site for residue SUE B 1202 source : AC4 16) chain B residue 1138 type sequence S description binding site for residue SUE B 1202 source : AC4 17) chain B residue 1139 type sequence S description binding site for residue SUE B 1202 source : AC4 18) chain B residue 1154 type sequence F description binding site for residue SUE B 1202 source : AC4 19) chain B residue 1155 type sequence R description binding site for residue SUE B 1202 source : AC4 20) chain B residue 1156 type sequence A description binding site for residue SUE B 1202 source : AC4 21) chain B residue 1157 type sequence A description binding site for residue SUE B 1202 source : AC4

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