eF-site ID 6c2m-ABCD PDB Code 6c2m Chain A, B, C, D click to enlarge Title Crystal structure of HCV NS3/4A protease variant Y56H in complex with MK-5172 Classification HYDROLASE/HYDROLASE Inhibitor Compound NS3 protease Source (C1KIK8_9HEPC) Sequence A:  KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQ VEGEVQIVSTATQTFLATSINGVLWTVHHGAGTRTIASPK GPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGIFRAAVSTRGVAKAVDFIPVESLETTM B:  KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQ VEGEVQIVSTATQTFLATSINGVLWTVHHGAGTRTIASPK GPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGIFRAAVSTRGVAKAVDFIPVESLETTM C:  KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQ VEGEVQIVSTATQTFLATSINGVLWTVHHGAGTRTIASPK GPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGIFRAAVSTRGVAKAVDFIPVESLETTM D:  KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQ VEGEVQIVSTATQTFLATSINGVLWTVHHGAGTRTIASPK GPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGIFRAAVSTRGVAKAVDFIPVESLETTM Description Functional site 1) chain A residue 1097 type sequence C description binding site for residue ZN A 1201 source : AC1 2) chain A residue 1099 type sequence C description binding site for residue ZN A 1201 source : AC1 3) chain A residue 1145 type sequence C description binding site for residue ZN A 1201 source : AC1 4) chain A residue 1043 type sequence F description binding site for residue SUE A 1202 source : AC2 5) chain A residue 1056 type sequence H description binding site for residue SUE A 1202 source : AC2 6) chain A residue 1057 type sequence H description binding site for residue SUE A 1202 source : AC2 7) chain A residue 1058 type sequence G description binding site for residue SUE A 1202 source : AC2 8) chain A residue 1078 type sequence V description binding site for residue SUE A 1202 source : AC2 9) chain A residue 1081 type sequence D description binding site for residue SUE A 1202 source : AC2 10) chain A residue 1123 type sequence R description binding site for residue SUE A 1202 source : AC2 11) chain A residue 1135 type sequence L description binding site for residue SUE A 1202 source : AC2 12) chain A residue 1136 type sequence K description binding site for residue SUE A 1202 source : AC2 13) chain A residue 1137 type sequence G description binding site for residue SUE A 1202 source : AC2 14) chain A residue 1138 type sequence S description binding site for residue SUE A 1202 source : AC2 15) chain A residue 1139 type sequence S description binding site for residue SUE A 1202 source : AC2 16) chain A residue 1154 type sequence F description binding site for residue SUE A 1202 source : AC2 17) chain A residue 1155 type sequence R description binding site for residue SUE A 1202 source : AC2 18) chain A residue 1156 type sequence A description binding site for residue SUE A 1202 source : AC2 19) chain A residue 1157 type sequence A description binding site for residue SUE A 1202 source : AC2 20) chain B residue 1097 type sequence C description binding site for residue ZN B 1201 source : AC3 21) chain B residue 1099 type sequence C description binding site for residue ZN B 1201 source : AC3 22) chain B residue 1145 type sequence C description binding site for residue ZN B 1201 source : AC3 23) chain B residue 1041 type sequence Q description binding site for residue SUE B 1202 source : AC4 24) chain B residue 1043 type sequence F description binding site for residue SUE B 1202 source : AC4 25) chain B residue 1056 type sequence H description binding site for residue SUE B 1202 source : AC4 26) chain B residue 1057 type sequence H description binding site for residue SUE B 1202 source : AC4 27) chain B residue 1058 type sequence G description binding site for residue SUE B 1202 source : AC4 28) chain B residue 1078 type sequence V description binding site for residue SUE B 1202 source : AC4 29) chain B residue 1081 type sequence D description binding site for residue SUE B 1202 source : AC4 30) chain B residue 1123 type sequence R description binding site for residue SUE B 1202 source : AC4 31) chain B residue 1132 type sequence I description binding site for residue SUE B 1202 source : AC4 32) chain B residue 1135 type sequence L description binding site for residue SUE B 1202 source : AC4 33) chain B residue 1136 type sequence K description binding site for residue SUE B 1202 source : AC4 34) chain B residue 1137 type sequence G description binding site for residue SUE B 1202 source : AC4 35) chain B residue 1138 type sequence S description binding site for residue SUE B 1202 source : AC4 36) chain B residue 1139 type sequence S description binding site for residue SUE B 1202 source : AC4 37) chain B residue 1154 type sequence F description binding site for residue SUE B 1202 source : AC4 38) chain B residue 1155 type sequence R description binding site for residue SUE B 1202 source : AC4 39) chain B residue 1156 type sequence A description binding site for residue SUE B 1202 source : AC4 40) chain B residue 1157 type sequence A description binding site for residue SUE B 1202 source : AC4 41) chain A residue 1001 type sequence S description binding site for residue SO4 C 1201 source : AC5 42) chain A residue 1002 type sequence G description binding site for residue SO4 C 1201 source : AC5 43) chain A residue 1003 type sequence D description binding site for residue SO4 C 1201 source : AC5 44) chain A residue 1004 type sequence T description binding site for residue SO4 C 1201 source : AC5 45) chain C residue 1011 type sequence R description binding site for residue SO4 C 1201 source : AC5 46) chain C residue 1012 type sequence G description binding site for residue SO4 C 1201 source : AC5 47) chain C residue 1015 type sequence G description binding site for residue SO4 C 1201 source : AC5 48) chain C residue 1097 type sequence C description binding site for residue ZN C 1202 source : AC6 49) chain C residue 1099 type sequence C description binding site for residue ZN C 1202 source : AC6 50) chain C residue 1145 type sequence C description binding site for residue ZN C 1202 source : AC6 51) chain C residue 1041 type sequence Q description binding site for residue SUE C 1203 source : AC7 52) chain C residue 1056 type sequence H description binding site for residue SUE C 1203 source : AC7 53) chain C residue 1057 type sequence H description binding site for residue SUE C 1203 source : AC7 54) chain C residue 1078 type sequence V description binding site for residue SUE C 1203 source : AC7 55) chain C residue 1081 type sequence D description binding site for residue SUE C 1203 source : AC7 56) chain C residue 1123 type sequence R description binding site for residue SUE C 1203 source : AC7 57) chain C residue 1132 type sequence I description binding site for residue SUE C 1203 source : AC7 58) chain C residue 1135 type sequence L description binding site for residue SUE C 1203 source : AC7 59) chain C residue 1136 type sequence K description binding site for residue SUE C 1203 source : AC7 60) chain C residue 1137 type sequence G description binding site for residue SUE C 1203 source : AC7 61) chain C residue 1138 type sequence S description binding site for residue SUE C 1203 source : AC7 62) chain C residue 1139 type sequence S description binding site for residue SUE C 1203 source : AC7 63) chain C residue 1154 type sequence F description binding site for residue SUE C 1203 source : AC7 64) chain C residue 1155 type sequence R description binding site for residue SUE C 1203 source : AC7 65) chain C residue 1156 type sequence A description binding site for residue SUE C 1203 source : AC7 66) chain C residue 1157 type sequence A description binding site for residue SUE C 1203 source : AC7 67) chain D residue 1097 type sequence C description binding site for residue ZN D 1201 source : AC8 68) chain D residue 1099 type sequence C description binding site for residue ZN D 1201 source : AC8 69) chain D residue 1145 type sequence C description binding site for residue ZN D 1201 source : AC8 70) chain D residue 1149 type sequence H description binding site for residue ZN D 1201 source : AC8 71) chain D residue 1056 type sequence H description binding site for residue SUE D 1202 source : AC9 72) chain D residue 1057 type sequence H description binding site for residue SUE D 1202 source : AC9 73) chain D residue 1058 type sequence G description binding site for residue SUE D 1202 source : AC9 74) chain D residue 1078 type sequence V description binding site for residue SUE D 1202 source : AC9 75) chain D residue 1081 type sequence D description binding site for residue SUE D 1202 source : AC9 76) chain D residue 1123 type sequence R description binding site for residue SUE D 1202 source : AC9 77) chain D residue 1132 type sequence I description binding site for residue SUE D 1202 source : AC9 78) chain D residue 1135 type sequence L description binding site for residue SUE D 1202 source : AC9 79) chain D residue 1136 type sequence K description binding site for residue SUE D 1202 source : AC9 80) chain D residue 1137 type sequence G description binding site for residue SUE D 1202 source : AC9 81) chain D residue 1138 type sequence S description binding site for residue SUE D 1202 source : AC9 82) chain D residue 1139 type sequence S description binding site for residue SUE D 1202 source : AC9 83) chain D residue 1154 type sequence F description binding site for residue SUE D 1202 source : AC9 84) chain D residue 1155 type sequence R description binding site for residue SUE D 1202 source : AC9 85) chain D residue 1156 type sequence A description binding site for residue SUE D 1202 source : AC9 86) chain D residue 1157 type sequence A description binding site for residue SUE D 1202 source : AC9

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