eF-site ID 6c2m-A PDB Code 6c2m Chain A click to enlarge Title Crystal structure of HCV NS3/4A protease variant Y56H in complex with MK-5172 Classification HYDROLASE/HYDROLASE Inhibitor Compound NS3 protease Source (C1KIK8_9HEPC) Sequence A:  KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQ VEGEVQIVSTATQTFLATSINGVLWTVHHGAGTRTIASPK GPVTQMYTNVDKDLVGWQAPQGSRSLTPCTCGSSDLYLVT RHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAG HAVGIFRAAVSTRGVAKAVDFIPVESLETTM Description Functional site 1) chain A residue 1097 type sequence C description binding site for residue ZN A 1201 source : AC1 2) chain A residue 1099 type sequence C description binding site for residue ZN A 1201 source : AC1 3) chain A residue 1145 type sequence C description binding site for residue ZN A 1201 source : AC1 4) chain A residue 1043 type sequence F description binding site for residue SUE A 1202 source : AC2 5) chain A residue 1056 type sequence H description binding site for residue SUE A 1202 source : AC2 6) chain A residue 1057 type sequence H description binding site for residue SUE A 1202 source : AC2 7) chain A residue 1058 type sequence G description binding site for residue SUE A 1202 source : AC2 8) chain A residue 1078 type sequence V description binding site for residue SUE A 1202 source : AC2 9) chain A residue 1081 type sequence D description binding site for residue SUE A 1202 source : AC2 10) chain A residue 1123 type sequence R description binding site for residue SUE A 1202 source : AC2 11) chain A residue 1135 type sequence L description binding site for residue SUE A 1202 source : AC2 12) chain A residue 1136 type sequence K description binding site for residue SUE A 1202 source : AC2 13) chain A residue 1137 type sequence G description binding site for residue SUE A 1202 source : AC2 14) chain A residue 1138 type sequence S description binding site for residue SUE A 1202 source : AC2 15) chain A residue 1139 type sequence S description binding site for residue SUE A 1202 source : AC2 16) chain A residue 1154 type sequence F description binding site for residue SUE A 1202 source : AC2 17) chain A residue 1155 type sequence R description binding site for residue SUE A 1202 source : AC2 18) chain A residue 1156 type sequence A description binding site for residue SUE A 1202 source : AC2 19) chain A residue 1157 type sequence A description binding site for residue SUE A 1202 source : AC2 20) chain A residue 1001 type sequence S description binding site for residue SO4 C 1201 source : AC5 21) chain A residue 1002 type sequence G description binding site for residue SO4 C 1201 source : AC5 22) chain A residue 1003 type sequence D description binding site for residue SO4 C 1201 source : AC5 23) chain A residue 1004 type sequence T description binding site for residue SO4 C 1201 source : AC5

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