eF-site ID 6c2c-B PDB Code 6c2c Chain B click to enlarge Title The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme Classification HYDROLASE Compound dihydrocoumarin hydrolase, AncDHCH1 Source (6C2C) Sequence B:  GTIGSMAAAPQVKTQAPGFYRMMLGDFEVTALSDGTVDLP VDKLLNQPPAKTQSALAKSFLKAPLETSVNAYLVNTGSKL VLVDTGAAGLFGPTLGKLAANLKAAGYQPEQVDEIYITHM HPDHVGGLMANEQAAFPNAVVRADQKDADFWLSQANLDKA PDDEKGFFQGAMASLNPYVKAGKFKPFSGNTDLVPGIKAL ASHGHTPGHTTYVVESKGQKLVLLGDLIHVAAVQFDDPSV TIQFDSDSKAAAAERKKAFADAAKGGYLIGAAHLSFPGIG HIRADGKGYRFVPVNYSVA Description Functional site 1) chain B residue 118 type sequence D description binding site for residue ZN B 401 source : AC5 2) chain B residue 119 type sequence H description binding site for residue ZN B 401 source : AC5 3) chain B residue 221 type sequence D description binding site for residue ZN B 401 source : AC5 4) chain B residue 268 type sequence H description binding site for residue ZN B 401 source : AC5 5) chain B residue 114 type sequence H description binding site for residue ZN B 402 source : AC6 6) chain B residue 116 type sequence H description binding site for residue ZN B 402 source : AC6 7) chain B residue 200 type sequence H description binding site for residue ZN B 402 source : AC6 8) chain B residue 221 type sequence D description binding site for residue ZN B 402 source : AC6 9) chain B residue 32 type sequence V description binding site for residue PEG B 404 source : AC8 10) chain B residue 86 type sequence F description binding site for residue PEG B 404 source : AC8 11) chain B residue 116 type sequence H description binding site for residue PEG B 404 source : AC8 12) chain B residue 118 type sequence D description binding site for residue PEG B 404 source : AC8 13) chain B residue 162 type sequence F description binding site for residue PEG B 404 source : AC8 14) chain B residue 268 type sequence H description binding site for residue PEG B 404 source : AC8

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