eF-site ID 6c2c-AB PDB Code 6c2c Chain A, B click to enlarge Title The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme Classification HYDROLASE Compound dihydrocoumarin hydrolase, AncDHCH1 Source (6C2C) Sequence A:  GTIGSMAAAPQVKTQAPGFYRMMLGDFEVTALSDGTVDLP VDKLLNQPPAKTQSALAKSFLKAPLETSVNAYLVNTGSKL VLVDTGAAGLFGPTLGKLAANLKAAGYQPEQVDEIYITHM HPDHVGGLMANEQAAFPNAVVRADQKDADFWLSQANLDKA PDDEKGFFQGAMASLNPYVKAGKFKPFSGNTDLVPGIKAL ASHGHTPGHTTYVVESKGQKLVLLGDLIHVAAVQFDDPSV TIQFDSDSKAAAAERKKAFADAAKGGYLIGAAHLSFPGIG HIRADGKGYRFVPVNYSVA B:  GTIGSMAAAPQVKTQAPGFYRMMLGDFEVTALSDGTVDLP VDKLLNQPPAKTQSALAKSFLKAPLETSVNAYLVNTGSKL VLVDTGAAGLFGPTLGKLAANLKAAGYQPEQVDEIYITHM HPDHVGGLMANEQAAFPNAVVRADQKDADFWLSQANLDKA PDDEKGFFQGAMASLNPYVKAGKFKPFSGNTDLVPGIKAL ASHGHTPGHTTYVVESKGQKLVLLGDLIHVAAVQFDDPSV TIQFDSDSKAAAAERKKAFADAAKGGYLIGAAHLSFPGIG HIRADGKGYRFVPVNYSVA Description Functional site 1) chain A residue 118 type sequence D description binding site for residue ZN A 401 source : AC1 2) chain A residue 119 type sequence H description binding site for residue ZN A 401 source : AC1 3) chain A residue 221 type sequence D description binding site for residue ZN A 401 source : AC1 4) chain A residue 268 type sequence H description binding site for residue ZN A 401 source : AC1 5) chain A residue 114 type sequence H description binding site for residue ZN A 402 source : AC2 6) chain A residue 116 type sequence H description binding site for residue ZN A 402 source : AC2 7) chain A residue 200 type sequence H description binding site for residue ZN A 402 source : AC2 8) chain A residue 221 type sequence D description binding site for residue ZN A 402 source : AC2 9) chain A residue 32 type sequence V description binding site for residue PEG A 404 source : AC4 10) chain A residue 117 type sequence P description binding site for residue PEG A 404 source : AC4 11) chain A residue 118 type sequence D description binding site for residue PEG A 404 source : AC4 12) chain A residue 162 type sequence F description binding site for residue PEG A 404 source : AC4 13) chain A residue 239 type sequence F description binding site for residue PEG A 404 source : AC4 14) chain A residue 268 type sequence H description binding site for residue PEG A 404 source : AC4 15) chain B residue 118 type sequence D description binding site for residue ZN B 401 source : AC5 16) chain B residue 119 type sequence H description binding site for residue ZN B 401 source : AC5 17) chain B residue 221 type sequence D description binding site for residue ZN B 401 source : AC5 18) chain B residue 268 type sequence H description binding site for residue ZN B 401 source : AC5 19) chain B residue 114 type sequence H description binding site for residue ZN B 402 source : AC6 20) chain B residue 116 type sequence H description binding site for residue ZN B 402 source : AC6 21) chain B residue 200 type sequence H description binding site for residue ZN B 402 source : AC6 22) chain B residue 221 type sequence D description binding site for residue ZN B 402 source : AC6 23) chain B residue 32 type sequence V description binding site for residue PEG B 404 source : AC8 24) chain B residue 86 type sequence F description binding site for residue PEG B 404 source : AC8 25) chain B residue 116 type sequence H description binding site for residue PEG B 404 source : AC8 26) chain B residue 118 type sequence D description binding site for residue PEG B 404 source : AC8 27) chain B residue 162 type sequence F description binding site for residue PEG B 404 source : AC8 28) chain B residue 268 type sequence H description binding site for residue PEG B 404 source : AC8

Display surface Download Links