eF-site ID 6c2c-A PDB Code 6c2c Chain A click to enlarge Title The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme Classification HYDROLASE Compound dihydrocoumarin hydrolase, AncDHCH1 Source (6C2C) Sequence A:  GTIGSMAAAPQVKTQAPGFYRMMLGDFEVTALSDGTVDLP VDKLLNQPPAKTQSALAKSFLKAPLETSVNAYLVNTGSKL VLVDTGAAGLFGPTLGKLAANLKAAGYQPEQVDEIYITHM HPDHVGGLMANEQAAFPNAVVRADQKDADFWLSQANLDKA PDDEKGFFQGAMASLNPYVKAGKFKPFSGNTDLVPGIKAL ASHGHTPGHTTYVVESKGQKLVLLGDLIHVAAVQFDDPSV TIQFDSDSKAAAAERKKAFADAAKGGYLIGAAHLSFPGIG HIRADGKGYRFVPVNYSVA Description Functional site 1) chain A residue 118 type sequence D description binding site for residue ZN A 401 source : AC1 2) chain A residue 119 type sequence H description binding site for residue ZN A 401 source : AC1 3) chain A residue 221 type sequence D description binding site for residue ZN A 401 source : AC1 4) chain A residue 268 type sequence H description binding site for residue ZN A 401 source : AC1 5) chain A residue 114 type sequence H description binding site for residue ZN A 402 source : AC2 6) chain A residue 116 type sequence H description binding site for residue ZN A 402 source : AC2 7) chain A residue 200 type sequence H description binding site for residue ZN A 402 source : AC2 8) chain A residue 221 type sequence D description binding site for residue ZN A 402 source : AC2 9) chain A residue 32 type sequence V description binding site for residue PEG A 404 source : AC4 10) chain A residue 117 type sequence P description binding site for residue PEG A 404 source : AC4 11) chain A residue 118 type sequence D description binding site for residue PEG A 404 source : AC4 12) chain A residue 162 type sequence F description binding site for residue PEG A 404 source : AC4 13) chain A residue 239 type sequence F description binding site for residue PEG A 404 source : AC4 14) chain A residue 268 type sequence H description binding site for residue PEG A 404 source : AC4

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