eF-site ID 6c1o-B PDB Code 6c1o Chain B click to enlarge Title FGFR1 kinase domain complexed with FIIN-1 Classification Transferase/Transferase inhibitor Compound Fibroblast growth factor receptor 1 Source (FGFR1_HUMAN) Sequence B:  ELPEDPRWELPRDRLVLGKPLGEFGQVVLAEAIGLKPNRV TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLL GACTQDGPLYVIVEYASKGNLREYLQARRPQLSSKDLVSC AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP SQRPTFKQLVEDLDRIVALTSN Description Functional site 1) chain B residue 492 type sequence V description binding site for residue MK9 B 801 source : AC3 2) chain B residue 514 type sequence K description binding site for residue MK9 B 801 source : AC3 3) chain B residue 531 type sequence E description binding site for residue MK9 B 801 source : AC3 4) chain B residue 535 type sequence M description binding site for residue MK9 B 801 source : AC3 5) chain B residue 559 type sequence V description binding site for residue MK9 B 801 source : AC3 6) chain B residue 561 type sequence V description binding site for residue MK9 B 801 source : AC3 7) chain B residue 562 type sequence E description binding site for residue MK9 B 801 source : AC3 8) chain B residue 563 type sequence Y description binding site for residue MK9 B 801 source : AC3 9) chain B residue 564 type sequence A description binding site for residue MK9 B 801 source : AC3 10) chain B residue 630 type sequence L description binding site for residue MK9 B 801 source : AC3 11) chain B residue 640 type sequence A description binding site for residue MK9 B 801 source : AC3 12) chain B residue 641 type sequence D description binding site for residue MK9 B 801 source : AC3 13) chain B residue 642 type sequence F description binding site for residue MK9 B 801 source : AC3 14) chain B residue 625 type ACT_SITE sequence A description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 570 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 16) chain B residue 629 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 17) chain B residue 643 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 18) chain B residue 486 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 19) chain B residue 516 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 20) chain B residue 564 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 21) chain B residue 465 type MOD_RES sequence L description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI3 22) chain B residue 732 type MOD_RES sequence M description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI5

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