eF-site ID 6c1o-AB
PDB Code 6c1o
Chain A, B

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Title FGFR1 kinase domain complexed with FIIN-1
Classification Transferase/Transferase inhibitor
Compound Fibroblast growth factor receptor 1
Source (FGFR1_HUMAN)
Sequence A:  ELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKD
KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN
IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPYNPS
HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN
VLVTEDNVMKIADFGLLPVKWMAPEALFDRIYTHQSDVWS
FGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC
TNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE
B:  ELPEDPRWELPRDRLVLGKPLGEFGQVVLAEAIGLKPNRV
TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLL
GACTQDGPLYVIVEYASKGNLREYLQARRPQLSSKDLVSC
AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG
LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY
PGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP
SQRPTFKQLVEDLDRIVALTSN
Description


Functional site

1) chain A
residue 484
type
sequence L
description binding site for residue MK9 A 801
source : AC1

2) chain A
residue 492
type
sequence V
description binding site for residue MK9 A 801
source : AC1

3) chain A
residue 512
type
sequence A
description binding site for residue MK9 A 801
source : AC1

4) chain A
residue 514
type
sequence K
description binding site for residue MK9 A 801
source : AC1

5) chain A
residue 531
type
sequence E
description binding site for residue MK9 A 801
source : AC1

6) chain A
residue 535
type
sequence M
description binding site for residue MK9 A 801
source : AC1

7) chain A
residue 559
type
sequence V
description binding site for residue MK9 A 801
source : AC1

8) chain A
residue 561
type
sequence V
description binding site for residue MK9 A 801
source : AC1

9) chain A
residue 562
type
sequence E
description binding site for residue MK9 A 801
source : AC1

10) chain A
residue 563
type
sequence Y
description binding site for residue MK9 A 801
source : AC1

11) chain A
residue 564
type
sequence A
description binding site for residue MK9 A 801
source : AC1

12) chain A
residue 567
type
sequence G
description binding site for residue MK9 A 801
source : AC1

13) chain A
residue 568
type
sequence N
description binding site for residue MK9 A 801
source : AC1

14) chain A
residue 630
type
sequence L
description binding site for residue MK9 A 801
source : AC1

15) chain A
residue 640
type
sequence A
description binding site for residue MK9 A 801
source : AC1

16) chain A
residue 641
type
sequence D
description binding site for residue MK9 A 801
source : AC1

17) chain A
residue 642
type
sequence F
description binding site for residue MK9 A 801
source : AC1

18) chain A
residue 539
type
sequence G
description binding site for residue SO4 A 802
source : AC2

19) chain A
residue 540
type
sequence K
description binding site for residue SO4 A 802
source : AC2

20) chain A
residue 618
type
sequence K
description binding site for residue SO4 A 802
source : AC2

21) chain B
residue 492
type
sequence V
description binding site for residue MK9 B 801
source : AC3

22) chain B
residue 514
type
sequence K
description binding site for residue MK9 B 801
source : AC3

23) chain B
residue 531
type
sequence E
description binding site for residue MK9 B 801
source : AC3

24) chain B
residue 535
type
sequence M
description binding site for residue MK9 B 801
source : AC3

25) chain B
residue 559
type
sequence V
description binding site for residue MK9 B 801
source : AC3

26) chain B
residue 561
type
sequence V
description binding site for residue MK9 B 801
source : AC3

27) chain B
residue 562
type
sequence E
description binding site for residue MK9 B 801
source : AC3

28) chain B
residue 563
type
sequence Y
description binding site for residue MK9 B 801
source : AC3

29) chain B
residue 564
type
sequence A
description binding site for residue MK9 B 801
source : AC3

30) chain B
residue 630
type
sequence L
description binding site for residue MK9 B 801
source : AC3

31) chain B
residue 640
type
sequence A
description binding site for residue MK9 B 801
source : AC3

32) chain B
residue 641
type
sequence D
description binding site for residue MK9 B 801
source : AC3

33) chain B
residue 642
type
sequence F
description binding site for residue MK9 B 801
source : AC3

34) chain A
residue 625
type ACT_SITE
sequence A
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897
source Swiss-Prot : SWS_FT_FI1

35) chain B
residue 625
type ACT_SITE
sequence A
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897
source Swiss-Prot : SWS_FT_FI1

36) chain A
residue 486
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI2

37) chain B
residue 570
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI2

38) chain B
residue 629
type BINDING
sequence V
description
source Swiss-Prot : SWS_FT_FI2

39) chain B
residue 643
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI2

40) chain A
residue 516
type BINDING
sequence L
description
source Swiss-Prot : SWS_FT_FI2

41) chain A
residue 564
type BINDING
sequence A
description
source Swiss-Prot : SWS_FT_FI2

42) chain A
residue 570
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI2

43) chain A
residue 629
type BINDING
sequence V
description
source Swiss-Prot : SWS_FT_FI2

44) chain A
residue 643
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI2

45) chain B
residue 486
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI2

46) chain B
residue 516
type BINDING
sequence L
description
source Swiss-Prot : SWS_FT_FI2

47) chain B
residue 564
type BINDING
sequence A
description
source Swiss-Prot : SWS_FT_FI2

48) chain A
residue 465
type MOD_RES
sequence L
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
source Swiss-Prot : SWS_FT_FI3

49) chain A
residue 585
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
source Swiss-Prot : SWS_FT_FI3

50) chain A
residue 587
type MOD_RES
sequence P
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
source Swiss-Prot : SWS_FT_FI3

51) chain B
residue 465
type MOD_RES
sequence L
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
source Swiss-Prot : SWS_FT_FI3

52) chain A
residue 484-514
type prosite
sequence LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK
source prosite : PS00107

53) chain A
residue 619-631
type prosite
sequence CIHRDLAARNVLV
description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV
source prosite : PS00109

54) chain A
residue 732
type MOD_RES
sequence M
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
source Swiss-Prot : SWS_FT_FI5

55) chain B
residue 732
type MOD_RES
sequence M
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
source Swiss-Prot : SWS_FT_FI5


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