eF-site ID 6c1c-B
PDB Code 6c1c
Chain B

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Title FGFR1 kinase complex with inhibitor SN37116
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Fibroblast growth factor receptor 1
Source (FGFR1_HUMAN)
Sequence B:  YELPEDPRWELPRDRLVLGKPLGEGFGQVVLAEAIGLDKP
NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNII
NLLGACTQDGPLYVIVEYASKGNLREYLQARRPQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA
DFGLALPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL
GGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDC
WHAVPSQRPTFKQLVEDLDRIVALTSN
Description


Functional site

1) chain B
residue 484
type
sequence L
description binding site for residue YY6 B 801
source : AC2

2) chain B
residue 514
type
sequence K
description binding site for residue YY6 B 801
source : AC2

3) chain B
residue 531
type
sequence E
description binding site for residue YY6 B 801
source : AC2

4) chain B
residue 559
type
sequence V
description binding site for residue YY6 B 801
source : AC2

5) chain B
residue 561
type
sequence V
description binding site for residue YY6 B 801
source : AC2

6) chain B
residue 562
type
sequence E
description binding site for residue YY6 B 801
source : AC2

7) chain B
residue 564
type
sequence A
description binding site for residue YY6 B 801
source : AC2

8) chain B
residue 571
type
sequence E
description binding site for residue YY6 B 801
source : AC2

9) chain B
residue 630
type
sequence L
description binding site for residue YY6 B 801
source : AC2

10) chain B
residue 640
type
sequence A
description binding site for residue YY6 B 801
source : AC2

11) chain B
residue 641
type
sequence D
description binding site for residue YY6 B 801
source : AC2

12) chain B
residue 665
type
sequence K
description binding site for residue SO4 B 802
source : AC3

13) chain B
residue 702
type
sequence P
description binding site for residue SO4 B 802
source : AC3

14) chain B
residue 703
type
sequence G
description binding site for residue SO4 B 802
source : AC3

15) chain B
residue 625
type ACT_SITE
sequence A
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897
source Swiss-Prot : SWS_FT_FI1

16) chain B
residue 570
type BINDING
sequence R
description
source Swiss-Prot : SWS_FT_FI2

17) chain B
residue 629
type BINDING
sequence V
description
source Swiss-Prot : SWS_FT_FI2

18) chain B
residue 643
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI2

19) chain B
residue 486
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI2

20) chain B
residue 516
type BINDING
sequence L
description
source Swiss-Prot : SWS_FT_FI2

21) chain B
residue 564
type BINDING
sequence A
description
source Swiss-Prot : SWS_FT_FI2

22) chain B
residue 465
type MOD_RES
sequence L
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
source Swiss-Prot : SWS_FT_FI3

23) chain B
residue 732
type MOD_RES
sequence M
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
source Swiss-Prot : SWS_FT_FI5


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