eF-site ID 6c1c-B PDB Code 6c1c Chain B click to enlarge Title FGFR1 kinase complex with inhibitor SN37116 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Fibroblast growth factor receptor 1 Source (FGFR1_HUMAN) Sequence B:  YELPEDPRWELPRDRLVLGKPLGEGFGQVVLAEAIGLDKP NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNII NLLGACTQDGPLYVIVEYASKGNLREYLQARRPQLSSKDL VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA DFGLALPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL GGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDC WHAVPSQRPTFKQLVEDLDRIVALTSN Description Functional site 1) chain B residue 484 type sequence L description binding site for residue YY6 B 801 source : AC2 2) chain B residue 514 type sequence K description binding site for residue YY6 B 801 source : AC2 3) chain B residue 531 type sequence E description binding site for residue YY6 B 801 source : AC2 4) chain B residue 559 type sequence V description binding site for residue YY6 B 801 source : AC2 5) chain B residue 561 type sequence V description binding site for residue YY6 B 801 source : AC2 6) chain B residue 562 type sequence E description binding site for residue YY6 B 801 source : AC2 7) chain B residue 564 type sequence A description binding site for residue YY6 B 801 source : AC2 8) chain B residue 571 type sequence E description binding site for residue YY6 B 801 source : AC2 9) chain B residue 630 type sequence L description binding site for residue YY6 B 801 source : AC2 10) chain B residue 640 type sequence A description binding site for residue YY6 B 801 source : AC2 11) chain B residue 641 type sequence D description binding site for residue YY6 B 801 source : AC2 12) chain B residue 665 type sequence K description binding site for residue SO4 B 802 source : AC3 13) chain B residue 702 type sequence P description binding site for residue SO4 B 802 source : AC3 14) chain B residue 703 type sequence G description binding site for residue SO4 B 802 source : AC3 15) chain B residue 625 type ACT_SITE sequence A description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 570 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 17) chain B residue 629 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 18) chain B residue 643 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 19) chain B residue 486 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 20) chain B residue 516 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 21) chain B residue 564 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 22) chain B residue 465 type MOD_RES sequence L description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 732 type MOD_RES sequence M description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI5

Display surface Download Links