eF-site ID 6c1b-AB PDB Code 6c1b Chain A, B click to enlarge Title FGFR1 kinase complex with inhibitor SN37118 Classification Transferase/Transferase inhibitor Compound Fibroblast growth factor receptor 1 Source (FGFR1_HUMAN) Sequence A:  LPEDPRWELPRDRLVLGKPLGQVVLAEAIGLDKDKPNRVT KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLG ACTQDGPLYVIVEYASKGNLREYLQARRPEEQLSSKDLVS CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF GLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV PSQRPTFKQLVEDLDRIVALTSNQE B:  YELPEDPRWELPRDRLVLGKPLGEGQVVLAEAIRVTKVAV KMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ DGPLYVIVEYASKGNLREYLQARRQLSSKDLVSCAYQVAR GMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLLPVKW MAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPT FKQLVEDLDRIVALTS Description Functional site 1) chain A residue 484 type sequence L description binding site for residue YY4 A 801 source : AC1 2) chain A residue 492 type sequence V description binding site for residue YY4 A 801 source : AC1 3) chain A residue 514 type sequence K description binding site for residue YY4 A 801 source : AC1 4) chain A residue 531 type sequence E description binding site for residue YY4 A 801 source : AC1 5) chain A residue 535 type sequence M description binding site for residue YY4 A 801 source : AC1 6) chain A residue 559 type sequence V description binding site for residue YY4 A 801 source : AC1 7) chain A residue 561 type sequence V description binding site for residue YY4 A 801 source : AC1 8) chain A residue 562 type sequence E description binding site for residue YY4 A 801 source : AC1 9) chain A residue 564 type sequence A description binding site for residue YY4 A 801 source : AC1 10) chain A residue 567 type sequence G description binding site for residue YY4 A 801 source : AC1 11) chain A residue 568 type sequence N description binding site for residue YY4 A 801 source : AC1 12) chain A residue 571 type sequence E description binding site for residue YY4 A 801 source : AC1 13) chain A residue 630 type sequence L description binding site for residue YY4 A 801 source : AC1 14) chain A residue 640 type sequence A description binding site for residue YY4 A 801 source : AC1 15) chain A residue 641 type sequence D description binding site for residue YY4 A 801 source : AC1 16) chain B residue 484 type sequence L description binding site for residue YY4 B 801 source : AC2 17) chain B residue 492 type sequence V description binding site for residue YY4 B 801 source : AC2 18) chain B residue 514 type sequence K description binding site for residue YY4 B 801 source : AC2 19) chain B residue 531 type sequence E description binding site for residue YY4 B 801 source : AC2 20) chain B residue 559 type sequence V description binding site for residue YY4 B 801 source : AC2 21) chain B residue 561 type sequence V description binding site for residue YY4 B 801 source : AC2 22) chain B residue 562 type sequence E description binding site for residue YY4 B 801 source : AC2 23) chain B residue 563 type sequence Y description binding site for residue YY4 B 801 source : AC2 24) chain B residue 564 type sequence A description binding site for residue YY4 B 801 source : AC2 25) chain B residue 567 type sequence G description binding site for residue YY4 B 801 source : AC2 26) chain B residue 568 type sequence N description binding site for residue YY4 B 801 source : AC2 27) chain B residue 571 type sequence E description binding site for residue YY4 B 801 source : AC2 28) chain B residue 630 type sequence L description binding site for residue YY4 B 801 source : AC2 29) chain B residue 640 type sequence A description binding site for residue YY4 B 801 source : AC2 30) chain B residue 641 type sequence D description binding site for residue YY4 B 801 source : AC2 31) chain B residue 570 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 32) chain B residue 629 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 33) chain B residue 643 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 34) chain A residue 516 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 35) chain A residue 564 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 36) chain A residue 570 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 37) chain A residue 629 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 38) chain A residue 643 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 39) chain B residue 486 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 40) chain B residue 516 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 41) chain B residue 564 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 42) chain A residue 732 type MOD_RES sequence M description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI5 43) chain B residue 732 type MOD_RES sequence M description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI5 44) chain A residue 484-514 type prosite sequence LGQVVLAEAIGLDKDKPNRVTKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK source prosite : PS00107 45) chain A residue 619-631 type prosite sequence CIHRDLAARNVLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV source prosite : PS00109 46) chain A residue 625 type ACT_SITE sequence A description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897 source Swiss-Prot : SWS_FT_FI1 47) chain B residue 625 type ACT_SITE sequence A description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 465 type MOD_RES sequence L description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI3 49) chain B residue 465 type MOD_RES sequence L description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI3

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